Choroidal thickness using EDI-OCT in adult-onset vitelliform macular dystrophy

Abstract

BackgroundTo compare choroidal thickness in patients with adult-onset foveomacular vitelliform dystrophy (AOFVD) with healthy subjects and to correlate choroidal thickness with age, gender and spherical equivalent.MethodsA prospective, observational study of 37 eyes (15 eyes in AOFVD group and 22 eyes in control group) was conducted. Images were acquired by enhanced depth imaging optical coherence tomography (EDI-OCT). Choroidal thickness measurements were performed in the subfoveal region and at 500, 1000 and 1500 µm intervals from the foveal center to nasal and to temporal regions for subsequent averaging of values.ResultsThe AOFVD group consisted of four male eyes (28.6 %) and 10 female eyes (71.4 %); age was 33–62 years; spherical equivalent (SE) ranged from −1.50 to 1.50 spherical diopters (SD); mean subfoveal thickness was 325.6 µm, ranging from 186 to 420 µm; and the average of thicknesses was 309.4 µm, ranging from 188 to 413 µm. The control group consisted of 12 male eyes (54.5 %) and 10 female eyes (45.5 %); age was 27–62 years; SE ranged from −2.50 to 0.50 SD; subfoveal thickness was 294.8 µm, ranging from 213 to 481 µm; and the average of thicknesses was 279.4 µm, ranging from 201 to 458 µm.ConclusionsThe AOFVD group and the control group showed similar choroidal thickness by correcting for age, SE and gender. Not yet known, completely, which biochemical and vascular flow alterations of the choroid, and which functional RPE changes may play a role in the pathogenesis of this disease. EDI-OCT, incorporated in some SD-OCT devices, allows higher quality assessment of the choroid. In this article, choroidal thickness of patients with AOFVD, a rare disease with a not fully understood pathogenesis, was assessed.

Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study

“…However, these authors further analyzed CT in eyes with different stages of disease and found mean choroidal thickening in the vitelliruptive stage with respect to controls, indicating that CT changes may be stage-sensitive [8]. In order to account for any stage-sensitive bias, we only included the vitelliform type and, in accordance with Palacios et al [9] and Grenga et al [8], we did not find any difference in CT between eyes with AOFVD and control eyes.…”

“…Ref. [9] Cennamo et al showed a reduction in the choriocapillaris (CC) vascular density in eyes with AOFVD with differences in the vitelliform with respect to the vitelliruptive stage using optical coherence tomography angiography (OCTA) [10]. Even if the choroid is a predominantly vascular tissue, it is also composed of a connective structure, nerves, melanocytes, and extracellular fluid.…”

Clinical Features, Prognosis, and Long-Term Response to Ranibizumab of Macular CNVs in Pattern Dystrophies Spectrum: A Pilot Study

“…In fact, while Palacios et al in 2016 demonstrated a comparable choroidal thickness between PD patients and healthy population [6], Coscas et al highlighted how subjects with wet AMD had thinner choroids compared to adult-onset foveomacular vitelliform dystrophy (AOFVD) not yet complicated by CNV, indicating a possible role in the differential diagnosis [7]. Grenga et al confirmed these findings and observed a progressive increase in the choroidal thickness based on the evolutive stage of the not yet neovascular disease, assuming a possible prognostic and pathogenetic role of the choroid in the AOFVD [8].…”