Choroidal vascularity index in hereditary optic neuropathies

Battista, Marco; Cascavilla, Maria Lucia; Borrelli, Enrico; Barresi, Costanza; Lari, Giorgio; Caporali, Leonardo; Viganò, Chiara; Berni, Alessandro; Carelli, Valerio; Bandello, Francesco; Barboni, Piero

doi:10.1038/s41433-023-02383-5

Cited by 2 publications

(4 citation statements)

References 33 publications

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“…T A B L E 2 Choroidal parameters study participants. significant differences (Battista et al, 2023). In contrast to our study, neither diurnal changes nor the AL was considered.…”

Section: Conc Lusionscontrasting

confidence: 57%

“…In contrast to our study, neither diurnal changes nor the AL was considered. Regarding choroidal vascular parameters, CC microvasculature has been studied in LHON‐Chr (Borrelli et al., 2018) and the choroidal vascular index in patients with symptomatic LHON (Battista et al., 2023; Jiang et al., 2021), with no significant changes observed. Our study confirms this and adds to the literature by analysing CC VD in all LHON stages and studying its possible association with VA.…”

Section: Discussionmentioning

confidence: 99%

“…They only studied patients with the m.11778G > A mutation; the macular region was not analysed. The two studies that reported ChT in LHON using SS‐OCT only included LHON‐Chr eyes and revealed conflicting results; one only included patients with the m.11778G > A mutation and reported decreased values (Darvizeh et al., 2020), whereas the other included patients with different mutations and revealed no significant differences (Battista et al., 2023). In contrast to our study, neither diurnal changes nor the AL was considered.…”

Section: Discussionmentioning

confidence: 99%

“…Conflicting results exist in the literature regarding the choroidal thickness (ChT). Two studies (Borrelli et al., 2016; Darvizeh et al., 2020) revealed decreased ChT in LHON chronic patients, whereas another (Battista et al., 2023) did not reveal any significant changes in the same disease stage. However, a trend towards increased peripapillary ChT in patients with symptomatic LHON has also been reported, significant only in the nasal sector (Jiang et al., 2021).…”

Section: Introductionmentioning

confidence: 95%

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Choriocapillaris and choroidal thickness in all Leber hereditary optic neuropathy stages using swept source technology

Castillo,

Berrozpe‐Villabona,

Miserachs‐García

et al. 2023

Acta Ophthalmologica

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PurposeThe role of the choroid in Leber hereditary optic neuropathy (LHON) remains unclear. The literature is scarce, with conflicting results and lacks axial length measurements. Therefore, we aimed to analyse the choriocapillaris (CC) vessel density (VD) and choroidal thickness (ChT) in all stages of LHON using swept source (SS) technology and considering the possible influence of axial length on choroidal parameters.MethodsThis was a prospective cross‐sectional observational study. A total of 119 eyes of 60 patients with molecularly confirmed LHON across all stages and 120 eyes of 60 control participants were included. We obtained the CC VD using optical coherence tomography angiography maps centred on the fovea. ChT was measured from the Bruch's membrane to the choroid‐sclera interface in the macular and peripapillary regions.ResultsThe CC VD was not significantly affected in any sector or average, except for a slight change in the superior region of chronic eyes (52.08 ± 1.62% vs. 53.50 ± 2.29%, p = 0.002). ChT demonstrated a trend towards decreased values in asymptomatic eyes and increased values in the symptomatic stages that failed to reach statistical significance in sectors corresponding to the papillomacular bundle except for the macular nasal inner sector of chronic eyes (281.10 ± 67.12 μm vs. 252.08 ± 70.55 μm, p = 0.045). No significant correlations were observed between visual acuity and CC VD or ChT.ConclusionThe CC VD remained stable across the LHON stages. Choroidal vasculature does not appear to play a role in LHON pathophysiology. Further research is needed on ChT as a potential biomarker of LHON.

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“…T A B L E 2 Choroidal parameters study participants. significant differences (Battista et al, 2023). In contrast to our study, neither diurnal changes nor the AL was considered.…”

Section: Conc Lusionscontrasting

confidence: 57%