Choroidale Neovaskularisation infolge einer „punctate inner choroidopathy“, dargestellt mittels optischer Kohärenztomographie-Angiographie

Leclaire, Martin Dominik; Clemens, Christoph R.; Eter, Nicole; Mihailovic, Nataša

doi:10.1007/s00347-020-01200-8

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…However, it is still not an option for patients with poorer economic conditions. As research on antivascular endothelial growth factor drugs continues, their unique benefits for choroidal neovascular disease are becoming increasingly apparent [18]. Vascular endothelial growth factor (VEGF) activates its receptors, causing vascular neovascularization and affecting vascular permeability through a series of responses [19,20].…”

Section: Discussionmentioning

confidence: 99%

Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease

Fang²,

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To investigate the clinical study of intravitreal injection of anti-VEGF drugs combined with intravitreal injection of tretinoin for the treatment of Coats disease. Methods. The medical records of 90 patients (120 eyes) with Coats disease admitted to our hospital from April 2010 to June 2021 were selected as retrospective study subjects and divided into control and treatment groups according to the numerical table method. There were 45 cases and 60 eyes in each group. Among them, intravitreal tretinoin drug was injected into the control group, and anti-VEGF drug was injected into the vitreous sclera of the treatment group on the basis of the control group. Results. Before treatment, the differences in visual acuity changes between the two groups were not statistically significant ( P > 0.05 ). After treatment, the light perception, manipulation, and indexes of both groups were significantly improved, and the treatment group was significantly better than the control group. This difference was statistically significant ( P < 0.05 ) for statistical study comparison. The effective rate of 95.56% in the treatment group was significantly higher than that of 86.67% in the control group, and the complication rate was significantly lower than that of the control group, with statistically significant differences ( P < 0.05 ). Conclusion. Intravitreal injection of anti-VEGF drugs combined with tretinoin injection can significantly improve the clinical efficacy of patients with Coats disease and improve visual acuity and central retinal thickness, which has certain reference value for the clinical treatment of Coats disease.

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Section: Discussionmentioning

confidence: 99%

Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease

Fang²,

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Thus, the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) of the retina and the choriocapillaris can be imaged and quantified separately [15,20]. With OCT-A, even minor vascular alterations can be visualized and monitored [21,22]. In contrast to dye-based methods, like FLA and ICG, OCT-A can be performed in cases of dye intolerance, severe renal insufficiency, or pregnancy [14,23].…”

Section: Of 13mentioning

confidence: 99%

“…VD measurements were created automatically and displayed and analyzed using Revue software (version 2017.1.0.151, Optovue Inc., Fremont, CA, USA). The OCT-A technology has been described elsewhere in detail [21]. OCT-A imaging of the macula was performed using a 3 × 3 mm scan.…”

Section: Optical Coherence Tomography Angiographymentioning

confidence: 99%

Microvascular Density Analysis of Patients with Inactive Systemic Lupus Erythematosus—A Two-Year Follow-Up Optical Coherence Tomography Angiography Study

Leclaire,

Esser,

Dierse

et al. 2024

JCM

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Background/Objectives: This study aims to investigate the long-term effect of inactive systemic lupus erythematosus (SLE) on the retinal microcirculation measured via optical coherence tomography angiography (OCT-A). Methods: Twenty-four eyes of 24 patients with inactive SLE under hydroxychloroquine (HCQ) therapy were included. The OCT-A data (mainly vessel density (VD) and foveal avascular zone (FAZ) data of the superficial and of the deep capillary plexus (SCP, DCP) and the choriocapillaris (CC)) were analyzed and compared between the baseline examination (t0) and 2 years later (t1). Results: At t1, VD in the whole en face SCP and in the CC was notably reduced compared to t0 (SCP: p = 0.001, CC: p = 0.013). VD in the DCP, CRT and FAZ area showed no difference at t1 compared to t0 (DCP: p = 0.128, FAZ: p = 0.332, CRT fovea: p = 0.296). Correlation analysis between the increase in cumulative doses of HCQ between t0 and t1 and the VD of the whole en face SCP did not show any correlation (Spearman r = 0.062 (95% CI −0.367; 0.477). Conclusions: SLE patients demonstrated a decrease in the retinal VD of the SCP and CC over a 2-year period. There was no correlation with the change in cumulative doses of HCQ. These results suggest an ongoing effect of the disease on the retinal and choriocapillary microcirculation.

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“…Thus, the retinal vascular plexuses and the choriocapillaris can be visualized and quantified separately [24,29]. With OCT-A, even minor vascular alterations like small quiescent neovascularization, that cannot be detected with conventional dye-based methods can be visualized and monitored [30,31]. In contrast to FA and ICG, OCT-A can be performed in case of dye intolerance, severe renal insufficiency or pregnancy [23,32].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous factors that influence the quantitative measurement parameters of OCT-A, such as axial length, the presence of cardiovascular disease and diabetes mellitus and the presence of cilioretinal vessels and age, have been described [30,[34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

Leclaire,

Storp,

Lahme

et al. 2024

Diagnostics

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Keratoconus (KC) is the most common corneal ectasia. Optical coherence tomography angiography (OCT-A) is a relatively new non-invasive imaging technique that allows the visualization and quantification of retinal and choriocapillary blood vessels. The aim of this study is to assess retinal and choriocapillary vessel density (VD) differences between KC patients and healthy controls and to investigate correlations between VD and KC severity. Fifty-two eyes were included in this exploratory study: twenty-six eyes from 26 KC patients and twenty-six eyes from 26 age- and gender-matched healthy controls. All patients underwent Scheimpflug corneal topography with Pentacam, axis lengths measurement and optical coherence tomography angiography (OCT-A). The thinnest spot in corneal pachymetry, maximum K (Kmax) and KC severity indices from the Belin/Ambrósio enhanced ectasia display (BAD) were also assessed. There was a distinct reduction particularly in the retinal VD of the superficial capillary plexus (SCP). Correlation analyses showed strong and moderate negative correlations between the VD in the macular SCP and BAD KC scores and between the SCP VD and Kmax. There was no difference in retinal thickness between the KC and healthy controls. With this study, further evidence for altered VD measurements by OCT-A in KC patients is given. For the first time, we demonstrated negative correlations between BAD KC scores and retinal blood vessel alterations. A major limitation of the study is the relatively small sample size. Since an artefactual reduction of the quantitative OCT-A measurements due to irregular corneal topography in KC must be assumed, it remains to be investigated whether there are also actual changes in the retinal microcirculation in KC.

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Choroidale Neovaskularisation infolge einer „punctate inner choroidopathy“, dargestellt mittels optischer Kohärenztomographie-Angiographie

Cited by 4 publications

References 11 publications

Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease

Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease

Microvascular Density Analysis of Patients with Inactive Systemic Lupus Erythematosus—A Two-Year Follow-Up Optical Coherence Tomography Angiography Study

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

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