Chromatin folding through nonuniform motorization by responsive motor proteins

Abstract

Chromatin is partially structured through the effects of biological motors. “Swimming motors” such as RNA polymerases and chromatin remodelers are thought to act differentially on the active parts of the genome and the stored inactive part. By systematically expanding the many-body master equation for chromosomes driven by swimming motors, we show that this nonuniform aspect of motorization leads to heterogeneously folded conformations, thereby contributing to chromosome compartmentalization.