Chromatin Regulation at Parental Gene Promoters by Pseudogene Sense lncRNAs

Abstract

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Pseudogenes and Liquid Phase Separation in Epigenetic Expression

“…Another interesting finding is that the effects of pseudogene on the structure of chromatin are implicated by computational and experimental evidence showing a connection between the modifications of DNA and histones, as well as chromatin remodeling (76). Similarly, mOct4P4 lncRNA interacts SUV39H1 (histone methyltransferase) and RNA binding protein FUS to target its parental Oct4 promoter heterochromatin formation (77). Moreover, the recent study shows that the methylation of parental genes and pseudogenes are different in a tissue-specific manner (78).…”