Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair

Abstract

DNA damage response (DDR) in eukaryotic cells is initiated in the chromatin context. DNA damage and repair depend on or have influence on the chromatin dynamics associated with genome stability. Epigenetic modifiers, such as chromatin remodelers, histone modifiers, DNA (de-)methylation enzymes, and noncoding RNAs regulate DDR signaling and DNA repair by affecting chromatin dynamics. In recent years, significant progress has been made in the understanding of plant DDR and DNA repair. SUPPRESSOR OF GAMMA RESPONSE1, RETINOBLASTOMA RELATED1 (RBR1)/E2FA, and NAC103 have been proven to be key players in the mediation of DDR signaling in plants, while plant-specific chromatin remodelers, such as DECREASED DNA METHYLATION1, contribute to chromatin dynamics for DNA repair. There is accumulating evidence that plant epigenetic modifiers are involved in DDR and DNA repair. In this review, I examine how DDR and DNA repair machineries are concertedly regulated in Arabidopsis thaliana by a variety of epigenetic modifiers directing chromatin remodeling and epigenetic modification. This review will aid in updating our knowledge on DDR and DNA repair in plants.

Histone H3K27 dimethylation landscapes contribute to genome stability and genetic recombination during wheat polyploidization

“…Consistent with the role of H3K27me2 in repressing TEs, more TEs were activated around the breakpoints relative to random regions (Figure S8(c)). These results suggest that H3K27me2 may inhibit structural variations or DNA double‐strand breaks (DSBs), as histone modifications and histone‐modifying complexes play important roles in chromatin‐based processes, including DNA repair and DNA replication (Kim, 2019). As both chromosome structural variation and genetic recombination are dependent on DSBs, we investigated the relationship between genetic recombination and H3K27me2 landscapes.…”

Roles of plant retinoblastoma protein: cell cycle and beyond

“…Plant and animal DNA damage responses share several general strategies, but they also exhibit several unique features. In addition to the conserved ATM and ATR pathways, the plant DDR depends on transcriptional activation of plant‐specific target genes such as SOG1, and on epigenetic modifiers (reviewed in Kim, ; Nisa et al , ). The first hint of the participation of RBR1 in DDR came from the observation that the typical nuclear foci marked by phosphorylated variant histone H2AX (γH2AX) formed after DNA damage contained E2F and depended on an intact RBR1‐binding motif in E2F (Lang et al , ).…”

Label-Free Proteomics Reveals the Molecular Mechanism of Subculture Induced Strain Degeneration and Discovery of Indicative Index for Degeneration in Pleurotus ostreatus

“…As known, chromatin modifications play a substantial role, not only in transcriptional activation and repression, but also in the process of many kinds of DNA damage repair through regulating the chromatin dynamics [ 65 , 66 , 67 , 68 , 69 , 70 ]. Epigenetic modifiers including chromatin remodelers, histone modifiers, DNA (de-)methylation enzymes, and even noncoding RNAs regulate the DNA damage response and repair system by affecting chromatin assembly and disassembly, releasing a conformational and biochemical environment from the packaged chromatin for the repair enzymes [ 71 , 72 , 73 ].…”