Chromatographic methods for carcinogenic/mutagenic nitropolycyclic aromatic hydrocarbons

Hayakawa, Kazuichi

doi:10.1002/1099-0801(200010)14:6<397::aid-bmc27>3.0.co;2-o

Cited by 26 publications

(18 citation statements)

References 108 publications

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“…The nitro-group of NPAHs is electrochemically, chemically or metal-catalytically reduced to a nitroso group, a hydroxyamino group and then an amino group (Hayakawa, 2000). The resulting amino-PAHs (APAHs) are Auorescent and this reaction pathway is very useful for the sensitive and selective detection of NPAHs.…”

Section: Analytical Methods For Nitro-pahs and Other Pahs Derivativesmentioning

confidence: 99%

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Liu

Lin

et al. 2007

Journal of Environmental Sciences

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Section: Analytical Methods For Nitro-pahs and Other Pahs Derivativesmentioning

confidence: 99%

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Liu

Lin

et al. 2007

Journal of Environmental Sciences

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“…Up to now, dinitropyrene, aminonitropyrene, and diaminopyrene were analyzed mainly by gas chromatography mass spectrometry (GC-MS), liquid chromatography coupled to electrochemical detection (LC-ECD), chemiluminescence detection (LC-CLD), and fluorescence detection (LC-FLD) methods [14]. Disadvantages of GC-MS are the low volatility of aminopyrenes and the need for excessive sample workup and derivatization of hydrophilic amino groups.…”

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confidence: 99%

Comparison of electrospray ionization, atmospheric pressure chemical ionization, and atmospheric pressure photoionization for the analysis of dinitropyrene and aminonitropyrene LC-MS/MS

Straube

Dekant

Völkel

2004

J. Am. Soc. Mass Spectrom.

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The only relevant source for human exposure to dinitropyrenes is diesel engine emissions. Due to this specificity, dinitropyrenes may be used as biomarkers for monitoring human exposure to diesel engine emissions. Only few analytical methods have been described for the quantitation of dinitropyrenes and their metabolites, aminonitropyrenes, and diaminopyrenes. Therefore, for dinitropyrenes, aminonitropyrenes, and diaminopyrenes were selected as model compounds for the development of a sensitive HPLC-MS/MS method (high performance liquid chromatography coupled to triple quadrupole mass spectrometry) was to quantify polyaromatic amines and nitroarenes in biological matrices was developed optimal methods by comparing electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI) sources. Dinitropyrene was not effectively ionized and diaminopyrene yielded mainly [M(.)](+) ions by electrospray ionization. With APCI and APPI, precursor ions of diaminopyrene and aminonitropyrene were [M + H](+) and [M(.)](-) for dinitropyrene. Precursor ions with [M - 30(.)](-) for dinitropyrene and [M - 30 + H](+) for aminonitropyrene were observed. Reversed and normal phase HPLC-MS/MS with ESI, APCI and APPI were optimized separately with respect to unequivocal analyte identification and sensitivity. Normal phase HPLC coupled to APPI-MS/MS gave the highest precision and sensitivity for aminonitropyrene (6%/0.2 pg on column) and dinitropyrene (9%/0.5 pg on column). The limit of detection in spiked rat plasma was 5 pg/100 microL for aminonitropyrene (accuracy 82%) and 10 pg/100 microL for dinitropyrene (accuracy 105%). In plasma of rats treated with dinitropyrene by oral administration, no detectable levels of dinitropyrene but higher aminonitropyrene levels compared with intratracheal instillation were observed. These findings clearly demonstrate that dinitropyrene was absorbed after oral and intratracheal application and that a reduction of nitro groups occurs to a high extent in the reductive environment of the intestine. To our knowledge, this is the first time that aminonitropyrene was observed in plasma after intratracheal or oral administration directly demonstrating the reductive metabolism of dinitropyrene in vivo.

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“…These filters were mounted on different volume air samplers as needed. Because the concentrations of NPAHs are very low in the atmosphere, a high‐volume air sampler (300–1000 L/min) is used for collecting airborne particulates such as PM 2.5 (Albinet, Leoz‐Garziandia, Budzinski, & Villenave, ; Hayakawa, ; Tang et al, ). Several higher‐level NPAHs (2‐nitrofluorene, 9‐nitroanthracene, 9‐nitrophenanthrene, 3‐nitrofluoranthene, 1‐nitropyrene, 2,7‐dinitrofluorene, 7‐nitrobenz[ a ]anthracene and 6‐nitrochrysene) in the atmosphere could be collected by using a low‐volume air sampler (38 L/min, 24 h) (Tutino, Di Gilio, Laricchiuta, Assennato, & de Gennaro, ).…”

Section: Analytical Methods Of Polycyclic Aromatic Hydrocarbons and Nmentioning

confidence: 99%

Recent analytical methods for atmospheric polycyclic aromatic hydrocarbons and their derivatives

Hayakawa

Tang

Toriba

2016

Biomedical Chromatography

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Polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are ubiquitous environmental pollutants. Moreover, some oxidative metabolites of these pollutants, such as hydroxylated and epoxide PAHs, cause endocrine disruption or produce reactive oxygen species. These compounds have become a large concern from the viewpoint of particulate matter (PM ) pollution. This report deals with recent studies concerning analytical methods for PAHs, NPAHs and related compounds in atmospheric and biological samples.

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Chromatographic methods for carcinogenic/mutagenic nitropolycyclic aromatic hydrocarbons

Cited by 26 publications

References 108 publications

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Comparison of electrospray ionization, atmospheric pressure chemical ionization, and atmospheric pressure photoionization for the analysis of dinitropyrene and aminonitropyrene LC-MS/MS

Recent analytical methods for atmospheric polycyclic aromatic hydrocarbons and their derivatives

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