2013
DOI: 10.1002/bmc.2911
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Chromatographic methods in the study of autism

Abstract: Research into biomarkers of autism is a new means of medical intervention in this disease. Chromatographic techniques, especially coupled with mass spectrometry, are widely used in determination of biomarkers and assessment of effectiveness of autism therapy owing to their sensitivity and selectivity. Among the chromatographic techniques gas chromatography and liquid chromatography, especially high-performance liquid chromatography, have found application in clinical trials. The high-performance liquid chromat… Show more

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Cited by 13 publications
(11 citation statements)
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“…Assessing classification performances of each model by an independent set appears to be necessary in order to minimize this overvaluation. 1 13 C HSQC NMR ROC curve was 0.03. The sensitivity of ROC curve analysis for independent validation was found better compared to the 1 H NMR (75% vs 62.5%) with an equal specificity between them (87.5%).…”
Section: −4mentioning
confidence: 94%
“…Assessing classification performances of each model by an independent set appears to be necessary in order to minimize this overvaluation. 1 13 C HSQC NMR ROC curve was 0.03. The sensitivity of ROC curve analysis for independent validation was found better compared to the 1 H NMR (75% vs 62.5%) with an equal specificity between them (87.5%).…”
Section: −4mentioning
confidence: 94%
“…Twin studies show that if one of a pair of identical twins meets the diagnostic criteria for ASD, the probability that the other will have the disorder is as high as 58% for boys and 60% for girls, while in the case of fraternal twins the probability falls to 21% for boys and 27% for girls (Hallmayer et al 2011 ). In order to get a thorough understanding of causes of ASD, numerous factors and their interactions have been examined (Szatmari et al 2012 ), including a number of genetic disorders (Xu et al 2012 ), anatomical brain abnormalities (cerebellum, brain stem, hippocampus, amygdale, and frontal lobes) (Belmonte et al 2004 ) and the comorbidities such as psychiatric, neurological, metabolic and gastrological disorders (Żurawicz et al 2013 ; Kałużna-Czaplińska et al 2013 , 2014 ; McElhanon et al 2014 ).…”
Section: Introductionmentioning
confidence: 99%
“…A promising new method that is designed to increase specificity of biomarkers in ASD is the multiplex immunoassay, a method that analyzes sets of biomarkers to create a diagnostic profile (182, 183). Furthermore, advances in chromatographic and proteomic techniques are also contributing to the progress of the field, allowing easier assessment of several substances (184, 185). …”
Section: Future Research Directionsmentioning
confidence: 99%