Chromatography–mass spectrometry methods for the quantitation of statins in biological samples

Nirogi, Ramakrishna; Mudigonda, Koteshwara; Kandikere, Vishwottam

doi:10.1016/j.jpba.2007.02.008

Cited by 79 publications

(46 citation statements)

References 100 publications

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“…The first one, published by Ertürk and coworkers in 2003 [70], reviews bio-analytical methods for lovastatin, simvastatin, pravastatin, fluvastatin and atorvastatin. The second one, published in 2007, is focused only on chromatography-mass spectrometry methods for the quantification of statins in biological samples [10]. In 2008 Nováková and co-workers [17] have published a review on HPLC methods for the determination of simvastatin and atorvastatin in various fields of application, including bioanalytical assays.…”

Section: Bioanalytical Methodsmentioning

confidence: 99%

“…Several GC/MS methods for determination of statins in biological samples have been reported [10]. Unfortunately, these methods are limited and not recommended for routine applications as they include analyte derivatization step prior to anaysis in order to obtain volatile derivatives of the drug molecule and therefore a complicate sample preparation procedures.…”

Section: Gas Chromatographymentioning

confidence: 99%

“…The levels of statins in biological fluids are very low because only about 5% of dosed statin reaches the systematic circulation. The liquid chromatography coupled to tandem mass spectrometry has become the method of choice for therapeutic plasma level monitoring of statins and their metabolites in pharmacokinetic investigations [10]. Generally, hyperlipidemic patients are treated with multiple-drug regime which commonly leads to drug interaction.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Nigović¹,

Mornar²,

Sertić³

2012

Chromatography - The Most Versatile Method of Chemical Analysis

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Section: Bioanalytical Methodsmentioning

confidence: 99%

Section: Gas Chromatographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Nigović¹,

Mornar²,

Sertić³

2012

Chromatography - The Most Versatile Method of Chemical Analysis

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“…Em um estudo foi relatado que a pravastatina atenua a reperfusão induzida por arritmias ventriculares letais. A atividade pleiotrópica provavelmente ocorre pela inibição da sobrecarga de cálcio intracelular (THUC et al, 2011;NIROGI et al, 2011).…”

Section: Efeitos Antiarrítmicosunclassified

Estatinas: efeitos pleiotrópicos. Statins: pleiotropic effects

Machado¹,

Munhoz²,

Fernandes³

2011

Publ. Biologicas

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RESUMODesde a descoberta da primeira estatina, em 1971, os estudos dessa classe de fármacos evoluem sem parar, com resultados interessantes, que extrapolam sua ação farmacológica principal. As estatinas demonstram ter uma gama de ações farmacológicas intrigantes, os chamados efeitos pleiotrópicos, que incluem efeitos anti-infl amatórios, antidiabéticos, melhora da doença de Alzheimer, melhora da disfunção endotelial, antioxidante, entre outros. O objetivo desta revisão narrativa é demonstrar a quantidade de estudos realizados com esta classe de fármacos e confi rmar a relevância dos efeitos pleiotrópicos. Palavras-chave: Estatinas. Efeitos pleiotrópicos. ABSTRACTSince the discovery of the fi rst statin in 1971, studies of this class of drugs have been constantly evolving with interesting results that go beyond their primary pharmacological action. Statins are shown to have an intriguing range of pharmacological actions, the so-called pleiotropic effects, including anti-infl ammatory, antidiabetic, improvement in Alzheimer disease, improvement in endothelial dysfunction, antioxidant, among others. The purpose of this literature review is to demonstrate the amount of studies about this class of drugs and confi rm the relevance of pleiotropic effects. Keywords: Statins. Pleiotropic effects. IntroduçãoEm 1971, Akiro Endo iniciou o primeiro projeto com o objetivo de inibir a atividade da hidroxi--metil glutaril coenzima A redutase (HMGCoA redutase), enzima responsável pela síntese do colesterol. Em experimentos, a mevastatina tornou-se um potente inibidor, mas devido aos efeitos colaterais que exercia acabou não sendo comercializada (YAMMOTO; SUDO;ENDO;.Em 1990, depois dos avanços no estudo, entraram no mercado três fármacos derivados da mevastatina: lovastatina, sinvastatina e a pravastatina, atuando nesta via. Atualmente a classe das estatinas é amplamente utilizada na diminuição do colesterol (ENDO, 2010).As estatinas são agentes hipolipemiantes, inibidores seletivos e competitivos, responsáveis pela conversão da HMG-CoA redutase a mevalonato, um precursor do colesterol. As estatinas diminuem os níveis plasmáticos de colesterol e lipoproteínas através da inibição da HMG-CoA redutase e da sín-tese de colesterol no fígado, aumentando o número

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“…It has also been demonstrated that this drug lowers the incidence of coronary heart disease in humans [1]. A number of analytical methods have been developed for its determination in pharmaceutical formulations or in biofluids either alone or in combination with other drugs [2][3][4][5][6][7][8]. These include determination of niacin by liquid chromatography-mass spectrometry [9], HPLC [9][10][11][12], flow injection and spectrofluorimetric analysis.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of HPTLC method for niacin and simvastatin in binary combination

Tiwari¹,

P.A.Sathe²

2010

ABB

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A simple, sensitive and validated HPTLC method has been developed to determine Niacin and simvastatin simultaneously in synthetic mixture form. Chromatographic separation was achieved on a RP18 plate using a mixture of Methanol: Water: Acetic acid (60: 40:0.1) at a wavelength of 237 nm. Linearity of the method was found to be in the concentration range of 5000.0-25000.0 µg/ml for niacin and 100.0-500.0 µg/ml for simvastatin with correlation coefficient greater than 0.999. The method can be used for simultaneous determination of Niacin and Simvastatin.

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Chromatography–mass spectrometry methods for the quantitation of statins in biological samples

Cited by 79 publications

References 100 publications

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Estatinas: efeitos pleiotrópicos. Statins: pleiotropic effects

Development and validation of HPTLC method for niacin and simvastatin in binary combination

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