Chromene-based Schiff base ligand: DNA interaction studies and characterization of tetranuclear zinc, nickel and iron complexes

Ressler, Andrew; Brandt, Olivia N.; Weaver, Ashton; Poor, Jenna E.; Ream, Anna; Summers, Nicolas A.; McMillen, Colin D.; Seeram, Navindra P.; Dougherty, William G.; Henry, Geneive E.

doi:10.1016/j.ica.2022.121363

Cited by 7 publications

(2 citation statements)

References 44 publications

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“…13 Many SBs are known to be used in a broad range of fields, including electroluminescence, 14-17 luminescence, [18][19][20] energy materials, 21 analytical chemistry, 22 food industry, 23 catalysis, [24][25][26] dye industries, 27,28 manufacturing of polymer-based substances, 29,30 use as detectors, [31][32][33] organic optoelectronic substances, 34,35 and pharmacological agents. 36 Pharmacological applications include anti-inflammatory, 37,38 antitumor, 39,40 anti-convulsant, [41][42][43][44] anti-fungal, 44-46 painkillers, 47 anti-bacterial, [48][49][50] anti-malarial, 51,52 antiviral, [53][54][55][56][57] anti-helminthic, 58,59 anti-oxidants, [60][61][62] and DNA interaction 63 and further along (Scheme 2). Because of their DNA-binding characteristics, SB metal complexes have garnered significant interest over the past 10 years.…”

Section: Introductionmentioning

confidence: 99%

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Yadav,

Poonia

2024

Applied Organom Chemis

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Cancer has become the second leading reason for death in the world. Cell biology states that the bulk of anti‐cancer medications focuses on DNA. A study of how complexes of metals interact with DNA is crucial in creation of the effective chemotherapy drugs. The interactions of DNA with Schiff base and their metal complexes are a thrust area for many researchers, and many papers have reported on them. An amino molecule reacts with carbonyl group to form a variety of chemicals called Schiff bases. Many studies have shown that Schiff bases have compounds that affect biological processes. Due to their potential use as novel reagents for biotechnology and medicine, the research of interactions between transition metal complexes and nucleic acids has grown significantly during the past few decades. It was shown that several metal Schiff base complexes may intercalate DNA. Small molecules can attach themselves to DNA through different ways, such as intercalation and groove binding. The main method to measure nuclease activity was gel electrophoresis, and the ligand alone had much lower activity than the complex. To set the stage for this analysis, a brief overview of Schiff bases and their complexes is provided. Further, this review provides an overview of the DNA interactions brought forth by Schiff base metal complexes. It also draws attention to new developments in the study of Schiff bases and their metal complexes and their prospective use as a bioactive core for DNA cleavage and binding.

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Section: Introductionmentioning

confidence: 99%

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Yadav,

Poonia

2024

Applied Organom Chemis

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“…The highly stable complexes formed by SBs with transition metals often lead to compounds with strongly enhanced activities in inorganic [22,23] and bioinorganic chemistry [24], materials science [25], and pharmacology for biomedical applications [26][27][28][29][30]. The most described biological activities regarding the SBs complexes are antitumoral [31][32][33][34][35], antioxidant [36,37], antidiabetic [38][39][40][41], antimalarial [42], antiarthritic [43], antimicrobial [44][45][46][47][48], neuroprotective, catalase-like and catecholase-like enzymatic [49,50], and DNA-binding [51,52]. Recently, Aggarwal et al (2022) [53] underlined the potential applicability of some SBs and their metal complexes for the treatment of COVID-19 [54], which may represent valid alternatives to the classic treatments for this disease [55,56].…”

Section: Introductionmentioning

confidence: 99%

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Iacopetta,

Ceramella,

Catalano

et al. 2023

Inorganics

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Complexes of Schiff bases (SBs) with metals are promising compounds exhibiting a broad range of applications, such as catalysts, polymers, dyes, and several biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic actions. Considering the crisis that the whole world is now facing against antimicrobial-resistant bacteria, in the present review, we chose to focus on the activity of SBs as antimicrobials, particularly underlying the most recent studies in this field. Finally, some interesting catalytic applications recently described for metal complexes with SBs have also been discussed.

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