Chromium‐Catalyzed Reductive Cross‐Coupling to Construct C−SS Bonds from Unactivated Alkyl Electrophiles

Abstract

Low‐valent chromium catalysts are cheap and less toxic compared to other transition metal catalysts. Here in, we reported a ligand‐free chromium(III)‐catalyzed manganese reductive cross‐coupling of unactivated alkyl electrophiles, such as alkyl sulfonates and alkyl chlorides, with trisulfide dioxides as thiolation agents to form carbon‐sulfur bonds. The powerful method featured ample substrate scope and wide functional group tolerance, constructing a large number of unsymmetrical disulfides under simple conditions.