Chromosomal Damage in LSD Users

Egozcue, J.; Irwin, S. T.; Maruffo, Cesar A.

doi:10.1001/jama.1968.03140160024006

Cited by 49 publications

(11 citation statements)

References 22 publications

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“…Several groups of investigators have observed increased chromosomal breakage in cells from LSD users [11,15,20,36], while others have.been unable to confirm these findings [5,24,33]. Several possible explanations for these discrepancies exist because of obvious variables in the populations studied.…”

Section: Discussionmentioning

confidence: 97%

“…21]. Additionally, an increase in chromosomal breakage in peripheral leukocytes of users of LSD has also Materials and Methods been observed by several investigators [11,15,20,36]. During these studies, preliminary evidence of trans-The mother-child pairs, both of the subject and of the placental passage suggested that chromosomal damage control groups, were volunteers from a middle class background and all had completed varying levels of college education.…”

Section: Introductionmentioning

confidence: 93%

“…to the developing human fetus might be observed following maternal ingestion of LSD during pregnancy The ability of the hallucinogen, lysergic acid diethyl- [11,15,36]. Therefore, additional children exposed to amide , to induce chromosomal damage in LSD during various times of gestation were investihuman leukocytes has been demonstrated in vitro [10, gated.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

et al. 1968

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ExtractThis paper reports the cytogenetic investigation of nine children exposed to LSD-25 ,in utero, four children of'other LSD users not exposed in utero, the mothers of these children, and six additional adults taking the drug. In comparison with matched controls, significantly elevated frequencies of chromosomal damage were observed in all the individuals exposed. The frequencies of aberrations, however, were markedly reduced in those children not exposed in utero. Eight structural rearrangements were observed, six dicentric chromosomes and two quadriradial formations, among those individuals exposed to the drug, but none was observed in the controls. In spite of obvious chromosomal aberrations, all of the individuals in this study were apparently healthy and showed no obvious birth defects. Speculation

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

et al. 1968

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“…In many cases, these earlier studies were refuted and retracted (e.g. Cohen et al, 1967 ; Dishotsky et al, 1971 ; Egozcue et al, 1968 ). Unfortunately, this did not generate the same media attention as the original work ( Strassman, 1984 ), meaning that earlier studies played a major role in shaping media representations of psychedelics, ultimately shaping public opinion.…”

Section: Physiological Risksmentioning

confidence: 99%

Adverse effects of psychedelics: From anecdotes and misinformation to systematic science

Schlag

Aday

Salam³

et al. 2022

J Psychopharmacol

186

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Background: Despite an increasing body of research highlighting their efficacy to treat a broad range of medical conditions, psychedelic drugs remain a controversial issue among the public and politicians, tainted by previous stigmatisation and perceptions of risk and danger. Objective: This narrative review examines the evidence for potential harms of the classic psychedelics by separating anecdotes and misinformation from systematic research. Methods: Taking a high-level perspective, we address both psychological and psychiatric risks, such as abuse liability and potential for dependence, as well as medical harms, including toxicity and overdose. We explore the evidence base for these adverse effects to elucidate which of these harms are based largely on anecdotes versus those that stand up to current scientific scrutiny. Results: Our review shows that medical risks are often minimal, and that many – albeit not all – of the persistent negative perceptions of psychological risks are unsupported by the currently available scientific evidence, with the majority of reported adverse effects not being observed in a regulated and/or medical context. Conclusions: This highlights the importance for clinicians and therapists to keep to the highest safety and ethical standards. It is imperative not to be overzealous and to ensure balanced media reporting to avoid future controversies, so that much needed research can continue.

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“…In the past strong positions have been taken with regard to the effect of psychotomimetic drugs on chromosomes. Some were adamant that LSD produces chromosomal damage (9,17) while others held a contrary view (3). Others reported grossly abnormal embryos after LSD was injected into mice in early pregnancy (1,2,13), while Warkany and Takacs (30), DiPaolo (8) disagreed.…”

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confidence: 99%

Psychodynamic Observations of the Research Worker in Psychiatry: Further Considerations

Herman

1972

Canadian Psychiatric Association Journal

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Chromosomal Damage in LSD Users

Cited by 49 publications

References 22 publications

The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

Adverse effects of psychedelics: From anecdotes and misinformation to systematic science

Psychodynamic Observations of the Research Worker in Psychiatry: Further Considerations

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