Chromosomal translocation activates stem cell micro-RNAs in thyroid adenoma

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

“…C19MC oncomiRs are upregulated in a spectrum of cancers (Huang et al, 2008;Rajaram et al, 2007;Rippe et al, 2010), but oncogenic genomic alterations are rare in most cancers. In contrast, our analyses revealed that a majority of ETMRs exhibit C19MC amplifications/gene fusions and few other recurrent CNAs, underscoring C19MC as a specific and major oncogenic driver in this disease.…”