Chromosome Aberrations and the Theory of RBE

Neary, G. J.; Preston, R. Julian; Savage, John R. K.

doi:10.1080/09553006714550881

Cited by 45 publications

(14 citation statements)

References 14 publications

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“…The most pervasive underlying idea, that of competition between lesion repair and misrepair occuring long after the initial energy deposition, arises from the Repair-Misrepair (RMR) formulation (1). As will be·seen, it also includes such ideas as the interaction of lesions (The Theory of Dual Radiation Action (2,3) and the RMR model (1) ), intra-and intertrack contributions (4,5), and repairable and irrepairable damage (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Lethal and Potentially Lethal Lesions Induced by Radiation --- A Unified Repair Model

Curtis¹

1986

Radiation Research

438

214

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Section: Introductionmentioning

confidence: 99%

Lethal and Potentially Lethal Lesions Induced by Radiation --- A Unified Repair Model

Curtis¹

1986

Radiation Research

438

214

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“…Another intriguing issue is the possibility that nascent oxygen can be formed within the tracks of high-LET particle beams [35,36], so that oxygen depletion at low LET might be reversed in very high LET conditions. The inverse relationship between RBE and dose per fraction is a further complication, which could potentially influence the magnitude of the oxygen effect in high-LET beams: further work is required in this respect, with realtime monitoring of oxygen tensions.…”

Section: Discussionmentioning

confidence: 99%

Revisiting the ultra-high dose rate effect: implications for charged particle radiotherapy using protons and light ions

Wilson

Jones²,

Yokoi³

et al. 2012

BJR

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Objective: To reinvestigate ultra-high dose rate radiation (UHDRR) radiobiology and consider potential implications for hadrontherapy. Methods: A literature search of cellular UHDRR exposures was performed. Standard oxygen diffusion equations were used to estimate the time taken to replace UHDRRrelated oxygen depletion. Dose rates from conventional and novel methods of hadrontherapy accelerators were considered, including spot scanning beam delivery, which intensifies dose rate. Results: The literature findings were that, for X-ray and electron dose rates of around 10 9 Gy s -1 , 5-10 Gy depletes cellular oxygen, significantly changing the radiosensitivity of cells already in low oxygen tension (around 3 mmHg or 0.4 kPa). The time taken to reverse the oxygen depletion of such cells is estimated to be over 20-30 s at distances of over 100 mm from a tumour blood vessel. In this time window, tumours have a higher hypoxic fraction (capable of reducing tumour control), so the next application of radiation within the same fraction should be at a time that exceeds these estimates in the case of scanned beams or with ultra-fast laser-generated particles. Conclusion: This study has potential implications for particle therapy, including lasergenerated particles, where dose rate is greatly increased. Conventional accelerators probably do not achieve the critical UHDRR conditions. However, specific UHDRR oxygen depletion experiments using proton and ion beams are indicated.

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“…Various authors proposed terms that are proportional to 0 2 for the production of chromosome aberrations, and these have been analyzed by Neary (63). A theoretical foundation was given by Kellerer and Rossi (64,65).…”

Section: Heavy-ion Dosimetrymentioning

confidence: 99%