Chromosome aberrations in workers exposed to organic solvents: Influence of polymorphisms in xenobiotic-metabolism and DNA repair genes

Hoyos-Giraldo, Luz Stella; Carvajal, Silvio; Cajas-Salazar, Nohelia; Ruiz, M.; Sánchez-Gómez, Adalberto

doi:10.1016/j.mrfmmm.2009.03.003

Cited by 31 publications

(36 citation statements)

References 57 publications

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Section: Study Populationmentioning

confidence: 99%

“…18,19 Details of the study population and organic solvents and paint exposure have been described previously. 18 Briefly, 150 car painters were recruited from several workshops from the southwest of Colombia. Age-and socioeconomic status-matched males were selected (n = 150, unexposed individuals) with no occupational exposure history to organic solvents or any known physical or chemical agent in the work place.…”

Section: Study Populationmentioning

confidence: 99%

“…Data were collected on health status, cancer history, other chronic diseases, lifestyle, nutrition, smoking habits, alcohol and medication intake, occupational and duration of exposure, protective measures and previous exposure to medical X-rays or treatment with known carcinogens. 18 Written informed consent was obtained from all participants who were informed of the study's aim, methodology and risks. The ethical (IRB) committee for scientific research from Universidad del Cauca-Colombia approved this study.…”

Section: Study Populationmentioning

confidence: 99%

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Gene-specific promoter methylation is associated with micronuclei frequency in urothelial cells from individuals exposed to organic solvents and paints

Hoyos-Giraldo

Escobar‐Hoyos

Saavedra-Trujillo

et al. 2015

J Expo Sci Environ Epidemiol

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Sufficient epidemiologic evidence has established an etiologic link between bladder cancer risk and occupational exposure as a painter to organic solvents. Currently, it remains to be established whether gene-specific promoter methylation contributes to bladder cancer development, including by enhancing chromosome breakage or loss. We investigated the effect of chronic exposure to organic solvents and paints on DNA methylation profiles in the promoter regions of four genes (GSTP1, p16(INK4a), APC and CDH1) and micronucleus (MN) frequency in exfoliated urothelial cells from voided urine from Colombian male non-smoking car painters and age-matched unexposed individuals. The exposed group had a higher percentage of individuals with >2 MNs/2000 cells compared with the unexposed group (P=0.04). Gene-specific analysis showed a significantly higher percentage of individuals with methylated GSTP1, p16(INK4a) and APC in the exposed group. Poisson regression analysis indicated that exposed individuals with methylated GSTP1 and p16(INK4a) promoters were more than twofold more likely to have an increase in MN frequency as compared with the reference. Finally, among exposed individuals with GSTP1 and p16(INK4a) methylated promoters, those with a greater age had a higher RR of increased MN frequency compared with younger exposed individuals with methylated promoters. These results support the conclusion that gene-specific promoter methylation may increase MN frequency in a dependent or independent interaction with occupational exposure to organic solvents.

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

See 1 more Smart Citation

Gene-specific promoter methylation is associated with micronuclei frequency in urothelial cells from individuals exposed to organic solvents and paints

Hoyos-Giraldo

Escobar‐Hoyos

Saavedra-Trujillo

et al. 2015

J Expo Sci Environ Epidemiol

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“…Boyacılar ve çeşitli organik çözücülere maruz kalan işçiler üzerinde yapılan Comet analizlerinde maruziyete bağlı olarak DNA hasarındaki derecelerin farklı olabileceği saptanmıştır (12,14,15). Ayrıca çeşitli organik çözücülere maruz kalan işçilerde PCR-RFLP yöntemi ile yapılan polimorfizm çalışmalarında; DNA onarım mekanizmasındaki aktivitenin XRCC1 gen bölgesinin 399. kodonundaki Arg/Gln ve XRCC3 geni 241. kodondaki Thr/Met aminoasit farklılığına neden olan polimorfizmlerle bağlantılı olarak kişiden kişiye farklılık gösterebileceği belirtilmiştir (15,16). Dolayısıyla, organik çözücülere maruziyette, polimorfik duyarlı kişilerin DNA onarım mekanizmasının, hasarlara vereceği yanıt farklı olabileceğinden bu kişiler toksik etkilere karşı daha duyarlı olabilmektedirler.…”

Section: ) Organik Karsinojenlerunclassified

Ksenobi̇yoti̇kleri̇n Dna Üzeri̇ndeki̇ Toksi̇k Etki̇leri̇ Ve Toksi̇kogeneti̇k

Özdemir¹,

Kayaaltı²,

Kaya-Akyüzlü³

2015

Marmara Pharm J

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“…Substâncias do grupo 2A (provável carcinógeno para humanos) também estão presentes no processo de trabalho de pintores, como bifenilas policloradas e o tricloroetileno 3,14,15 . Estudos de biomarcadores de efeitos genotóxicos têm sugerido que pintores apresentam maiores frequências de quebras de DNA, aberrações cromossômicas e micronúcleo quando comparados com os controles [16][17][18] Inicialmente, foram avaliadas a distribuição de frequências de todas as neoplasias em relação ao total de óbitos entre pintores brasileiros e a população geral do sexo masculino por faixas etárias (25-44 e 45-64 anos), escolaridade (nenhuma, 1-7 anos, ≥8 anos) e região de residência. Uma vez que as regiões Sul e Sudeste apresentam maior completude do preenchimento dos dados do SIM e cobertura dos óbitos acima de 95% em relação às demais, nossas análises se restringiram geograficamente a essas regiões 21,22 .…”

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Mortalidade por câncer entre pintores brasileiros das regiões Sul e Sudeste do Brasil

et al. 2016

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Resumo Como resultado de sua atividade profissional, pintores entram regularmente em contato com substâncias genotóxicas e carcinogênicas presentes em tintas, vernizes e massa corrida. Com isso, eles podem apresentar risco elevado para diversas doenças, dentre elas alguns cânceres. Este estudo teve por objetivo comparar a mortalidade por cânceres específicos entre pintores e a população geral nas regiões Sudeste e Sul do Brasil no período de 1996 a 2013. Os dados de morte por câncer foram obtidos por meio do Sistema de Informação sobre Mortalidade (SIM), de acordo com a 10ª revisão da Classificação Internacional de Doenças (CID-10). Para determinar os riscos de morte por cânceres específicos, foi calculada a razão de chance de mortalidade (RCM), estratificada por faixa etária (25-44 anos e 45-64 anos) e por região. Pintores mais velhos da região Sul e Sudeste apresentaram maiores chances de morte para câncer de orofaringe (RCM=1,73; IC95%:1,51-1,98), hipofaringe (RCM=1,56; IC95%:1,20-2,03) e laringe (RCM=1,45; IC95%:1,32-1,61), quando comparados com a população geral. Esses resultados sugerem que pintores podem estar sob maior risco de adoecer e morrer por cânceres específicos como os do trato respiratório superior.

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Chromosome aberrations in workers exposed to organic solvents: Influence of polymorphisms in xenobiotic-metabolism and DNA repair genes

Cited by 31 publications

References 57 publications

Gene-specific promoter methylation is associated with micronuclei frequency in urothelial cells from individuals exposed to organic solvents and paints

Gene-specific promoter methylation is associated with micronuclei frequency in urothelial cells from individuals exposed to organic solvents and paints

Ksenobi̇yoti̇kleri̇n Dna Üzeri̇ndeki̇ Toksi̇k Etki̇leri̇ Ve Toksi̇kogeneti̇k

Mortalidade por câncer entre pintores brasileiros das regiões Sul e Sudeste do Brasil

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