Chromosome evolution and improved cytogenetic maps of the Y chromosome in cattle, zebu, river buffalo, sheep and goat

Meo, G.P. Di; Perucatti, A.; Floriot, Sandrine; Incarnato, D.; Rullo, Rosario; Jambrenghi, Anna Caputi; Ferretti, Luca; Vonghia, G.; Cribiu, Edmond; Eggen, Andre A.; Iannuzzi, L.

doi:10.1007/s10577-005-2688-4

Cited by 54 publications

(71 citation statements)

References 24 publications

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“…, dog [Olivier et al, 1999;Young et al, 2008], horse [Shiue et al, 2000;Raudsepp and Chowdhary, 2008], bovidscaprids [Iannuzzi et al, 2000a;Di Meo et al, 2005;Das et al, 2009], pig [Quilter et al, 2002], cat [Murphy et al, 2007;Pearks Wilkerson et al, 2008], and alpaca [own unpublished data]. On the X chromosome, which is evolutionarily conserved among mammals [Ohno, 1967;Raudsepp et al, 2004a], the PAR is typically located at Xpter ( fig.…”

Section: The Par In Domestic Speciesmentioning

confidence: 99%

The Pseudoautosomal Region and Sex Chromosome Aneuploidies in Domestic Species

Raudsepp

Das²,

Avila³

et al. 2011

Sex Dev

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evidence about the likely involvement of PAR genes in placenta formation, early embryonic development and genomic imprinting are presented. Copyright © 2011 S. Karger AG, Basel The pseudoautosomal region (PAR) is a short region of sequence homology between the sex chromosomes and is involved in sex chromosome pairing, recombination and segregation in meiosis of the heterogametic sex. The region has been found in many plant and animal species, including mammals [Charlesworth et al., 2005;Ming and Moore, 2007].The mammalian PAR was discovered almost 80 years ago through studies of male meiosis in rats, where a synaptonemal complex between the X and Y was detected [Koller and Darlington, 1934]. Similar structures were soon found between the terminal ends of the X and Y chromosomes in several other eutherian species [Pathak and Elder, 1980], but not in marsupials [Sharp, 1982]. These observations have later been validated through detailed molecular genetic studies both in eutherian [Martin, 2006;Oliver-Bonet et al., 2006;Kauppi et al., 2011] and marsupial [Page et al., 2005[Page et al., , 2006 mammals.Whole or partial genome sequence data are available for almost all main domestic species -alpaca, cat, cat- Key WordsAneuploidy ؒ Domestic species ؒ Pseudoautosomal region ؒ Sex chromosomes ؒ X-monosomy ؒ X-trisomy AbstractThe pseudoautosomal region (PAR) is a unique and specialized segment on the mammalian sex chromosomes with known functions in male meiosis and fertility. Detailed molecular studies of the region in human and mouse show dramatic differences between the 2 PARs. Recent mapping efforts in horse, dog/cat, cattle/ruminants, pig and alpaca indicate that the PAR also varies in size and gene content between other species. Given that PAR genes escape X inactivation, these differences might critically affect the genetic consequences, such as embryonic survival and postnatal phenotypes of sex chromosome aneuploidies. The aim of this review is to combine the available information about the organization of the PAR in domestic species with the cytogenetic data on sex chromosome aneuploidies. We show that viable XO individuals are relatively frequently found in species with small PARs, such as horses, humans and mice but are rare or absent in species in which the PAR is substantially larger, like in cattle/ruminants, dogs, pigs, and alpacas. No similar correlation can be detected between the PAR size and the X chromosome trisomy in different species. Recent

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Section: The Par In Domestic Speciesmentioning

confidence: 99%

The Pseudoautosomal Region and Sex Chromosome Aneuploidies in Domestic Species

Raudsepp

Das²,

Avila³

et al. 2011

Sex Dev

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“…Indeed, the karyotype macrostructure (2n and chromosomal morphology) of karyotyped individuals was highly conserved, being similar to the standard karyotype of Capra hircus (Cribiu et al, 2001;Di Meo et al, 2005;Singh et al, 2011).…”

Section: Discussionmentioning

confidence: 62%

“…Actually, a non-random chromosomal arrangement in metaphase spreads has been found frequently in goats (Andraszek et al, 2009) and other species with several acrocentric chromosomes, e.g., cattle and buffalo (Di Berardino et al, 1981). This event is thought to facilitate Robertsonian rearrangements, thus giving rise to bi-armed chromosomes (Aguilar et al, 1999;Grapho-datsky et al, 2011) like those observed in the differentiated karyotype of sheep (2n = 54) (Di Meo et al, 2005).…”

Section: Discussionmentioning

confidence: 96%

“…Ever since, only a few cytogenetic reports have been published about goat breeds, e.g., Murciana-Granadina (Burguete, 1991) and Mahabubnagar (Ekambaram et al, 2011). Other studies are rather related to methodological or technical aspects (Mondal et al, 2007;Singh et al, 2011) or focused on chromosomal evolution in the family Bovidae (Di Meo et al, 2005;Schibler et al, 2009;Oh et al, 2011). Most reports describe conventional karyotype features, such as diploid number (2n) and chromosomal morphology, the identification of nucleolar organizer regions (NORs), and C-or G-banding patterns, although high-resolution cytogenetic techniques have already been developed (Di Meo et al, 2005;Schibler et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Identification of naturalized goat breeds under conservation from northeastern Brazil using chromosomal markers

Santos¹,

Affonso²,

Diniz³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. In order to provide the first cytogenetic data of naturalized and threatened goat breeds from northeastern Brazil, cytogenetic analyses were carried out in individuals of Repartida and Moxotó breeds raised in Bahia and Ceará States. Males and females of both breeds had 2n = 60, with 29 autosomal acrocentric pairs plus the sex chromosome pair. The number of nucleolar organizer region (NOR)-bearing chromosomes ranged from 6 to 8 per metaphase in Moxotó and Repartida goats, respectively. The active NORs in Repartida individuals were located exclusively at the terminal regions of the long arms, as usually detected in Bovidae. Otherwise, Moxotó specimens presented a large autosomal pair with NORs on short arms. GC-rich heterochromatin was detected at the centromeres in both breeds, although polymorphic terminal C-bands were visualized on pair 25 in Moxotó. In addition, GC-rich regions were detected at the terminal regions of the long arms of a single pair in Repartida and of 20 chromosomes in Moxotó goats. The differences in both the number and/or position of Ag-NORs and GC-rich sites between Repartida and Moxotó breeds represent efficient cytogenetic markers that can be used in the identification and conservation of the genetic integrity of each lineage. In spite of the small effective population size of these breeds, chromosomal abnormalities related to drift or inbreeding effects were absent in the samples analyzed.

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“…Although large-insert DNA libraries from closely related ruminant species such as cattle, goat, and sheep have been used for in situ hybridization experiments in buffalo (Di Meo et al, 2005Perucatti et al, 2009), a buffalo library is necessary for whole-genome physical mapping and isolation of genes and gene clusters as well as for the identification of regulatory elements. Herein we describe the construction of a river buffalo BAC library, a key resource for comparative gene-mapping studies, sequence assembly, and characterization of quantitative trait loci through positional cloning.…”

Section: Introductionmentioning

confidence: 99%

Construction and preliminary characterization of a river buffalo bacterial artificial chromosome library

Stafuzza

Abbey²,

Gill

et al. 2012

Genet. Mol. Res.

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ABSTRACT. River buffalo genome analyses have advanced significantly in the last decade, and the genome sequence of Bubalus bubalis will be available shortly. Nonetheless, large-insert DNA library resources such as bacterial artificial chromosomes (BAC) are still required for validation and accurate assembly of the genome sequence. We constructed a river buffalo BAC library containing 52,224 clones with an average insert size of 97 kb, representing 1.7 × coverage of the genome. This genomic resource for river buffalo will facilitate further studies in this economically important species allowing for instance, whole genome physical mapping and isolation of genes and gene clusters, contributing to the elucidation of gene organization and identification of regulatory elements.

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Chromosome evolution and improved cytogenetic maps of the Y chromosome in cattle, zebu, river buffalo, sheep and goat

Cited by 54 publications

References 24 publications

The Pseudoautosomal Region and Sex Chromosome Aneuploidies in Domestic Species

The Pseudoautosomal Region and Sex Chromosome Aneuploidies in Domestic Species

Identification of naturalized goat breeds under conservation from northeastern Brazil using chromosomal markers

Construction and preliminary characterization of a river buffalo bacterial artificial chromosome library

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