Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia

Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents.

“…Certain chromosome aberrations in lymphoma cells from exposed non-Hodgkin 's lymphoma patients are more common than in lymphoma cells from patients without any history of exposure to solvents (Brandt et al, submitted for publication). These findings are also analogous to results of chromosome studies with patients with acute nonlymphocytic leukemia and a history of exposure to potentially mutagenic chemicals (6,II,12,27). …”

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

“…In contrast to the case reports described above, several large-scale leukemia studies have been conducted that surveyed their subjects for information on prior chemical exposures (Cuneo et al, 1992;Golomb et al, 1982;Groupe, 1984;Iurlo et al, 1989;Li et al, 1989;Mitelman et al, 1978;Mitelman et al, 1981;Richardson et al, 1992). These studies compared chromosome changes in leukemia patients with various occupational chemical exposures and in those without exposure.…”

Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

“…However, previous occupational exposure to organic solvents, mainly benzene, has been suggested to increase the risk for AML with +8 as the sole change [47,48]. Further support for an etiologic role of benzene has come from in vitro studies, using interphase fluorescence in situ hybridization (FISH), showing that exposing peripheral blood cells or CD34+ cells from chord blood to metabolites of benzene, e.g., hydroquinone and benzenetriol, results in aneuploidy of chromosome 8 [49][50][51].…”