Chromosomes in the genesis and progression of ependymomas

Rogatto, Sílvia Regina; Casartelli, Cacilda; Rainho, Cláudia Aparecida; Barbieri‐Neto, José

doi:10.1016/0165-4608(93)90093-2

Cited by 44 publications

(24 citation statements)

References 20 publications

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“…Among primarily adult series, the loss of chromosome arm 22q is reported to occur in as many as 50% to 60% of cases (Neumann et al, 1993;Rogatto et al, 1993;Sawyer et al, 1994;Bijlsma et al, 1995;Wernicke et al, 1995;von Haken et al, 1996;Kramer et al, 1998). Small series of primary pediatric tumors have also demonstrated abnormalities of 17p, 6q, and 1 in some patients (Neumann et al, 1993;Sawyer et al, 1994;Bijlsma et al, 1995;Kramer et al, 1998).…”

Section: Introductionmentioning

confidence: 90%

Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma

Reardon

Entrekin

Sublett

et al. 1999

Genes Chromosom. Cancer

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Section: Introductionmentioning

confidence: 90%

Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma

Reardon

Entrekin

Sublett

et al. 1999

Genes Chromosom. Cancer

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“…Chromosome prepara- 122 Veiga et al tion and cytogenetic analysis were carried out by standard techniques on primary cultures, as previously described (Rogatto et al, 1993). The tumor fragments were dissociated with 0.4% type IV collagenase (Sigma), and the cells were grown in Ham's F-10 medium (Sigma) supplemented with 10% fetal calf serum.…”

Section: Cytogenetic Studiesmentioning

confidence: 99%

Classical and molecular cytogenetic analysis in head and neck squamous cell carcinomas

et al. 2003

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Head and neck carcinomas represent the sixth most frequent type of cancer in the world, and 90% are derived from squamous cells (HNSCC). In this study of 15 HNSCC cases, extensive aneuploidy was detected by G banding in most tumors. The most frequently observed numerical changes involved gain of a chromosome 22, and loss of chromosomes Y, 10, 17, and 19. The most frequent structural alteration was del(22)(q13.1). As compared to G-banding, fluorescence in situ hybridization (FISH) proved to be an effective technique for detecting aneuploidy. Interphase FISH with a chromosome 17 centromere probe disclosed a high frequency of monosomy for chromosome 17, in contrast with G-banding, by which clonal monosomy 17 was detected in only three of the tumors. Painting probes for chromosomes 5 and 16 were used to evaluate a selected series of HNSCC in which G-banding analysis had shown marker chromosomes. FISH analysis failed to confirm the origin of the marker chromosomes, but four out of five cases showed a significant loss of chromosomes 5. This difference between FISH and G-banding results may reflect the smaller number of metaphase analyzed as well as the criteria adopted for sorting these metaphases. Therefore results obtained solely by G-banding analysis should be considered with caution. Our data confirmed the involvement of chromosome 17 in head and neck squamous cell carcinomas.

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“…The presence of an inducible fragile site at 2q32 (Tcdeschi et al, 1987), the allelic losses at 2q32->q37 in lung carcinoma (Otsuka et al, 1996), and deletions at 2q32->q34 in ependy moma (Rogatto et al, 1993) have been reported. From this study, mutations of the STAT4 or the STAT1 gene may be related to the pathogenesis of human cancer, and should be studied further.…”

mentioning

confidence: 99%

cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2→q32.3

Yamamoto¹,

Kobayashi²,

Arai³

et al. 1997

Cytogenet Genome Res

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Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription (STAT). STAT4 is phosphorylated following interleukin (IL)-12 stimulation and is essential for IL-12 signal transduction. The human STAT4 cDNA was cloned, and both STAT4 and STAT1 genes were mapped to human chromosome bands 2q32.2→q32.3 by fluorescence in situ hybridization. These results suggest that STAT4 and STAT1 may have arisen via a tandem gene duplication. However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis.

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Chromosomes in the genesis and progression of ependymomas

Cited by 44 publications

References 20 publications

Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma

Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma

Classical and molecular cytogenetic analysis in head and neck squamous cell carcinomas

cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2→q32.3

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