Chromsome aberrations in cattle raised on bracken fern pasture

Moura, Joelma; Stocco, Rita de Cássia; Dagli, M.L.; D'Angelino, José Luiz; Birgel, Eduardo Harry; Beçak, Willy

doi:10.1007/bf01959166

Cited by 29 publications

(25 citation statements)

References 13 publications

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Section: Discussionmentioning

confidence: 99%

“…15 Since then, several studies have shown increased numbers of chromosome aberrations in cattle maintained on natural bracken fern 29 or with overt enzootic hematuria. 24,29 From the various toxic compounds that have been isolated from bracken fern, unequivocal urinary bladder carcinogenesis has been proved only for ptaquiloside. 19,20 At sublethal or subtoxic levels, ptaquiloside causes genotoxicity through the formation of a number of different DNA adducts, the main labile adducts occurring at the N-3 of adenine, and to a minor extent with the N-7 of guanine.…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Carvalho¹,

Naydan

Nunes³

et al. 2009

Veterinary Pathology

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Abstract. Fifty-six endothelial-derived urinary bladder tumor samples collected from 26 animals with bovine enzootic hematuria were selected for immunohistochemical studies. Expression of factor VIII-related antigen (FVIIIra), CD31, muscle-specific actin, uroplakin III (UPIII), and the cell cyclerelated proteins cyclin D1 and p53 was evaluated in hemangiomas, ''hemangioendotheliomas'' (a vascular tumor that histologically is intermediate in appearance between a hemangioma and a conventional hemangiosarcoma), and hemangiosarcomas. Although CD31 expression was seen in all endothelial tumors tested, FVIIIra was not expressed in poorly differentiated endothelial tumor cells from solid areas or in 7 muscle-invasive hemangiosarcomas. Cyclin D1 overexpression was seen in 53% of hemangiomas, 82% of hemangioendotheliomas, and 95% of hemangiosarcomas. P53 immunoreactivity was only seen in muscle-invasive hemangiosarcomas. The UPIII staining pattern, normally very intense on the apical aspect and cytoplasm of superficial urothelial cells, was altered in the urothelium in an estimated 25% of hemangiomas, most hemangioendotheliomas, and most hemangiosarcomas. In conclusion, CD31 is a better marker than FVIIIra in the characterization of bovine endothelial tumors. The cell cycle regulatory pathways involving cyclin D1 and p53 seem to be impaired in endothelial urinary bladder tumors, p53 immunoreactivity positively correlating with enhanced invasion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Carvalho¹,

Naydan

Nunes³

et al. 2009

Veterinary Pathology

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“…The involvement of papillomaviruses in the aetiology of chronic enzootic haematuria associated to bracken fern ingestion has been suggested for a long time (Jarrett et al 1978, Pachauri et al 1981, Moura et al 1988). However, the difficulty of the BPV diagnosis by conventional virological methods, such as virus isolation in cell culture, stimulated the development and assessment of molecular diagnostic techniques and some reports have shown the involvement of the BPV-2 in the aetiology of urinary bladder neoplastic lesions in cattle (Campo et al 1992, Stocco dos Santos et al 1998, Borzacchiello et al 2003, Wosiacki et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Bovine papillomavirus type 2 detection in the urinary bladder of cattle with chronic enzootic haematuria

Wosiacki

Claus

Alfieri

2006

Mem. Inst. Oswaldo Cruz

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“…It promotes the full in vitro transformation of primary bovine cells infected with BPV-4 DNA [26,99] and upregulates viral DNA transcription via a cis-acting element in the viral transcriptional promoter [42]. Moreover, bracken eating cattle with BEH and/or suffering from bladder cancer develop chromosomal abnormalities [67,80,88,101,129] due to a clastogenic activity of compounds from fern. Metabolites from ptaquiloside and quercetin along with other chemicals from bracken are also found in the blood, urine and milk of cows naturally exposed to bracken and suffering from bladder cancer [15,80].…”

Section: Bracken Fern As a Cofactor For Carcinogenesismentioning

confidence: 99%

Bovine papillomaviruses, papillomas and cancer in cattle

Borzacchiello¹,

Roperto²

2008

Vet. Res.

173

149

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-Bovine papillomaviruses (BPV) are DNA oncogenic viruses inducing hyperplastic benign lesions of both cutaneous and mucosal epithelia in cattle. Ten (BPV 1-10) different viral genotypes have been characterised so far. BPV 1-10 are all strictly species-specific but BPV 1/2 may also infect equids inducing fibroblastic tumours. These benign lesions generally regress but may also occasionally persist, leading to a high risk of evolving into cancer, particularly in the presence of environmental carcinogenic co-factors. Among these, bracken fern is the most extensively studied. The synergism between immunosuppressants and carcinogenic principles from bracken fern and the virus has been experimentally demonstrated for both urinary bladder and alimentary canal cancer in cows whose diets were based on this plant. BPV associated tumours have veterinary and agricultural relevance in their own right, although they have also been studied as a relevant model of Human papillomavirus (HPV). Recent insights into BPV biology have paved the way to new fields of speculation on the role of these viruses in neoplastic transformation of cells other than epithelial ones. This review will briefly summarise BPV genome organization, will describe in greater detail the functions of viral oncoproteins, the interaction between the virus and co-carcinogens in tumour development; relevant aspects of immunity and vaccines will also be discussed.

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Chromsome aberrations in cattle raised on bracken fern pasture

Cited by 29 publications

References 13 publications

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Bovine papillomavirus type 2 detection in the urinary bladder of cattle with chronic enzootic haematuria

Bovine papillomaviruses, papillomas and cancer in cattle

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