Chronic bisphenol A exposure alters behaviors of zebrafish (Danio rerio)

Wang, Ju; Wang, Xia; Xiong, Can; Liu, Jian; Hu, Bing; Zheng, Lei

doi:10.1016/j.envpol.2015.07.015

Cited by 33 publications

(12 citation statements)

References 46 publications

(51 reference statements)

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“…Multiple studies have demonstrated that EAE affects zebrafish swimming behaviors (35)(36)(37)(38). To determine whether reduced locomotion was present in adults after EAE, we assessed activity level (35,(39)(40)(41)(42)(43)(44). Adult fish were subjected to a 10-minute habituation period, followed by a monitored locomotion assay.…”

Section: Resultsmentioning

confidence: 99%

Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood

Weeks¹,

Bossé²,

Oderberg³

et al. 2020

Journal of Clinical Investigation

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Section: Resultsmentioning

confidence: 99%

Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood

Weeks¹,

Bossé²,

Oderberg³

et al. 2020

Journal of Clinical Investigation

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“…An increasing number of studies uses behavioral responses to monitor sublethal effects of pollutants such as PFOS or BPA on aquatic organisms Wang J. et al, 2015), and changes in, e.g., the photomotor response are commonly interpreted as evidence of potential neurotoxicity (Le Bihanic et al, 2015;Legradi et al, 2018). Yet, our results did not show any alteration of the LPMR by any of the different MPs preparations.…”

Section: Larval Behaviormentioning

confidence: 99%

Multi-Laboratory Hazard Assessment of Contaminated Microplastic Particles by Means of Enhanced Fish Embryo Test With the Zebrafish (Danio rerio)

Cormier

Batel

Cachot

et al. 2019

Front. Environ. Sci.

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As wide-spread pollutants in the marine environment, microplastics (MPs) have raised public concern about potential toxic effects in aquatic organisms, and, among others, MPs were suspected to act as a vector for organic pollutants to biota. The purpose of the present study was to investigate effects by three model pollutants, oxybenzone (BP3), benzo[a]pyrene (BaP), and perfluorooctane sulfonate (PFOS) adsorbed to polyethylene MPs on the basis of a standard assay, the acute fish embryo toxicity test (FET; OECD TG 236) with zebrafish (Danio rerio) supplemented by additional endpoints such as induction of ethoxyresorufin-O-deethylase (EROD) activity, modification of cyp1a gene transcription and changes in larval swimming behavior. FET assays were performed in three laboratories using slightly different husbandry and exposure conditions, which, however, were all fully compatible with the limits defined by OECD TG 236. This allowed for testing of potential changes in the FET assay due to protocol variations. The standard endpoints of the FET (acute embryotoxicity) did not reveal any acute toxicity for both virgin MPs and MPs spiked with BP3, BaP, and PFOS. With respect to sublethal endpoints, EROD activity was increased after exposure to MPs spiked with BP3 (3 h pulse) and MPs spiked with BaP (96 h continuous exposure). Cyp1a transcription was increased upon exposure to MPs spiked with BP3 or BaP. For the selected combination of MPs particles and contaminants, the basic FET proved not sensitive enough to reveal effects of (virgin and spiked) MPs. However, given that the FET can easily be supplemented by a broad variety of more subtle and sensitive endpoints, an enhanced FET protocol may provide a relevant approach with developmental stages of a vertebrate animal model, which is not protected by current EU animal welfare legislation (Directive EU 2010/63).

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“…In addition, BPA could also be found in almost all humans sampled at any time, suggesting its constant and ubiquitous nature of exposure (Vandenberg et al, 2012). As an endocrine disruptor, BPA could cause multiple effects including reproductive toxicity (Sieratowicz et al, 2011), developmental toxicity (Lomb o et al, 2015), neurotoxicity (Wang et al, 2015), immunotoxicity (Lee and Lim, 2010), and mutagenicity (Lee et al, 2013b). Thus, BPA has been gaining more and more attention.…”

Section: Introductionmentioning

confidence: 96%

Ecotoxicity of bisphenol A to Caenorhabditis elegans by multigenerational exposure and variations of stress response in vivo across generations

Zhou

Yang

et al. 2016

Environmental Pollution

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Chronic bisphenol A exposure alters behaviors of zebrafish (Danio rerio)

Cited by 33 publications

References 46 publications

Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood

Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood

Multi-Laboratory Hazard Assessment of Contaminated Microplastic Particles by Means of Enhanced Fish Embryo Test With the Zebrafish (Danio rerio)

Ecotoxicity of bisphenol A to Caenorhabditis elegans by multigenerational exposure and variations of stress response in vivo across generations

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