Chronic Colitis Mimicking Malignancy on 68Ga-FAPI PET/CT

Xiao, Yang; Huang, Yilin; Mou, Chunru; Liu, Huipan; Chen, Yue

doi:10.1097/rlu.0000000000003793

Cited by 9 publications

(10 citation statements)

References 8 publications

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“…68 Ga-DOTA-FAPI-04 is a novel PET agent that has been shown to be promising for imaging tumors 5,6 . In addition, 68 Ga-DOTA-FAPI-04 in multiple inflammatory lesions including tuberculosis, 7 arthritis, 8 chronic colitis, 9 esophagitis, 10 thyroiditis, 11 organizing pneumonia, 12 immunoglobulin G4–related disease, 13 SAPHO syndrome, 14 and dermatomyositis 15 has also been reported. In our case, 68 Ga-DOTA-FAPI-04 uptake was significantly increased in radioactive iodine–induced chronic parotitis.…”

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confidence: 99%

68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of Radioactive Iodine–Induced Chronic Parotitis

Zhang

et al. 2022

Clin Nucl Med

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68 Ga-DOTA-FAPI-04 is a promising PET agent for tumor imaging. However, inflammatory lesions can also show increased FAPI uptake. Herein, we reported a 52-year-old woman who underwent total thyroidectomy for thyroid papillary carcinoma 1 year ago and underwent adjuvant radioiodine therapy 1 month later. After 131 I therapy, she began to develop pain and swelling in bilateral cheeks, which developed into oral dryness. The patient was diagnosed with radioactive iodine-induced parotitis. 68 Ga-DOTA-FAPI-04 PET/CT showed the density of bilateral parotid glands increased, and the volume decreased with intense tracer uptake. 99m TcO 4 − salivary gland scintigraphy showed decreased tracer uptake in the bilateral parotid glands.

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confidence: 99%

68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of Radioactive Iodine–Induced Chronic Parotitis

Zhang

et al. 2022

Clin Nucl Med

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“…68 Ga-FAPI is a potential novel PET agent developed for the detection of a variety of primary tumors and metastatic tumors 1–4 . However, 68 Ga-FAPI also can have obvious accumulation at the sites of inflammatory diseases including cholecystitis, 5 colitis, 6 arthritis, 7 pulmonary cryptococcus, 8 and pancreatitis 9 . Our case indicates that granulomatous inflammation should be considered as one of the possible causes when focal FAPI activity was noted at the site of the orbital mass.…”

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confidence: 83%

Orbital Granulomatous Inflammation Mimicking Malignancy on 68Ga-FAPI PET/CT

et al. 2022

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A 31-year-old man presented with a left orbital mass for 3 months traumatic enucleation of the left eye. On 68 Ga-FAPI PET/CT images, the lesion presented as a soft tissue mass with irregular shape, filling the left orbital cavity and showing intense FAPI uptake. Based on imaging findings, a malignancy was suspected. However, the orbital mass was diagnosed as granulomatous inflammation by pathological biopsy.

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“…4,5 Also, FAPI uptake has been reported in nonmalignant diseases because of the chronic inflammation-induced transformation of fibroblasts to CAFs. [6][7][8][9] Zhang et al 10 showed that H. pylori infection-induced mesenchymal stem cells may transform to CAFs-like cells in gastric mucosa and cause developing of gastric lesions. Another study revealed that, due to chronic inflammation, activated macrophages also cause to the CAFs-like transformation of mesenchymal stem cells.…”

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confidence: 99%