Chronic Ethanol Ingestion During Puberty Alters the Transient Increase in Testicular 5α‐Reductase in the Swiss‐Webster Mouse

Anderson, Robert A.; Phillips, Jack F.; Zaneveld, L. J. D.

doi:10.1002/j.1939-4640.1989.tb00053.x

Cited by 11 publications

(5 citation statements)

References 22 publications

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“…Nevertheless, the effect of ibuprofen on plasma androgen levels is a reversible phenomenon, since it disappeared when the drug was administered for 60 days. Similar reversibility, related to toxic effects of ethanol on reproductive functions, has been reported [1].…”

Section: Discussionsupporting

confidence: 82%

Functional Activity of Mouse Sperm Was Not Affected by Low Doses of Aspirin-Like Drugs

Stutz

Martini

Ruiz³

et al. 2000

Archives of Andrology

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To investigate some possible effects of low doses of nonsteroidal anti-inflammatory drugs upon functional activity of mouse sperm, the authors injected lysine acetyl salicylate (im 14.3 mg/kg day(-1), ibuprofen (ip 5.6 mg/kg day(-1)), or piroxicam (ip 0.28 mg/kg day(-1) to pregnant females (the male cohort was sacrificed at adulthood) (A) or to adult males during 35 (B) or 60 (C) days. Parameters measured were motility, viability, acrosomal integrity, responses to hypoosmotic shock, in vitro fertilization index, and testosterone plasma levels. Salicylate evoked a slight reduction in the percentage of swollen gametes in A, and ibuprofen diminished testosterone plasma levels in B. The other parameters remained unchanged in all groups. Results are well supported by the low doses assayed, which are equivalent to the content of one tablet commercially available for each compound.

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Section: Discussionsupporting

confidence: 82%

Functional Activity of Mouse Sperm Was Not Affected by Low Doses of Aspirin-Like Drugs

Stutz

Martini

Ruiz³

et al. 2000

Archives of Andrology

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“…Ethanol exerts inhibitory effects on hormone release from both the pituitary gland [13,14] and the hypothalamus [15,16]. Chronic ethanol treatment of pubertal mice has profound effects on spermatogenesis [17], the Sertoli cells [ 181, and possibly on the number of testicular gonadotropin (hCG) receptors [19]. Thus it is believed that chronic treatment with ethanol also has a direct toxic effect on the secretory epithelium of the ventral lobe of the prostate.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural study of the ventral lobe of the prostate of rats submitted to experimental chronic alcoholism

Martinez¹,

Garcia²,

Padovani³

et al. 1993

The Prostate

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The effects of chronic alcohol ingestion on the ventral lobe of the prostate were studied in rats (Rattus norvegicus). Ultrastructural observations on the epithelial cells of the ventral lobe of the prostate showed irregularly shaped nuclei with deep infoldings, dilated RER cisternae, and a small number of microvilli covering the cell surface. After 90 and 135 days of alcohol treatment, the epithelial cells showed signs of degeneration.

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“…Interestingly, men with alcohol-associated liver disease demonstrate hypogonadism, resulting in a high risk of developing BPH [58,59]. Indeed, observations in the rat model of EtOH administration showed significantly decreased serum testosterone level [60][61][62], alterations of the hypothalamus-pituitary axis, and reduction in the weight of the prostate, testicles, and seminal vesicles [63,64].…”

Section: Alcohol's Influence On the Hormonal Status And Prostate Epit...mentioning

confidence: 99%

Alcohol and Prostate Cancer: Time to Draw Conclusions

Macke

Petrosyan

2022

Biomolecules

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It has been a long-standing debate in the research and medical societies whether alcohol consumption is linked to the risk of prostate cancer (PCa). Many comprehensive studies from different geographical areas and nationalities have shown that moderate and heavy drinking is positively correlated with the development of PCa. Nevertheless, some observations could not confirm that such a correlation exists; some even suggest that wine consumption could prevent or slow prostate tumor growth. Here, we have rigorously analyzed the evidence both for and against the role of alcohol in PCa development. We found that many of the epidemiological studies did not consider other, potentially critical, factors, including diet (especially, low intake of fish, vegetables and linoleic acid, and excessive use of red meat), smoking, family history of PCa, low physical activity, history of high sexual activities especially with early age of first intercourse, and sexually transmitted infections. In addition, discrepancies between observations come from selectivity criteria for control groups, questionnaires about the type and dosage of alcohol, and misreported alcohol consumption. The lifetime history of alcohol consumption is critical given that a prostate tumor is typically slow-growing; however, many epidemiological observations that show no association monitored only current or relatively recent drinking status. Nevertheless, the overall conclusion is that high alcohol intake, especially binge drinking, is associated with increased risk for PCa, and this effect is not limited to any type of beverage. Alcohol consumption is also directly linked to PCa lethality as it may accelerate the growth of prostate tumors and significantly shorten the time for the progression to metastatic PCa. Thus, we recommend immediately quitting alcohol for patients diagnosed with PCa. We discuss the features of alcohol metabolism in the prostate tissue and the damaging effect of ethanol metabolites on intracellular organization and trafficking. In addition, we review the impact of alcohol consumption on prostate-specific antigen level and the risk for benign prostatic hyperplasia. Lastly, we highlight the known mechanisms of alcohol interference in prostate carcinogenesis and the possible side effects of alcohol during androgen deprivation therapy.

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Chronic Ethanol Ingestion During Puberty Alters the Transient Increase in Testicular 5α‐Reductase in the Swiss‐Webster Mouse

Cited by 11 publications

References 22 publications

Functional Activity of Mouse Sperm Was Not Affected by Low Doses of Aspirin-Like Drugs

Functional Activity of Mouse Sperm Was Not Affected by Low Doses of Aspirin-Like Drugs

Ultrastructural study of the ventral lobe of the prostate of rats submitted to experimental chronic alcoholism

Alcohol and Prostate Cancer: Time to Draw Conclusions

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