Chronic exposure to low concentration of arsenic is immunotoxic to fish: Role of head kidney macrophages as biomarkers of arsenic toxicity to Clarias batrachus

Datta, Soma; Ghosh, Debabrata; Saha, Dhira Rani; Bhattacharaya, Shelley; Mazumder, Shibnath

doi:10.1016/j.aquatox.2009.01.002

Cited by 117 publications

(47 citation statements)

References 52 publications

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“…Heavy metals have also been shown to increase respiratory burst activity (Robohm 1986;Rice and Weeks 1991;Bols et al 2001). For instance, arsenic exposure leads to a significant increase in respiratory burst but a decrease in bactericidal activity (Datta et al 2009). …”

Section: Discussionmentioning

confidence: 97%

Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

et al. 2011

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The use of fish as sentinels of aquatic ecosystem health is a biologically relevant approach to environmental monitoring and assessment. We examined the health of the Ashtabula River using histologic, immunologic, and endocrine biomarkers in brown bullhead (BB; Ameiurus nebulosus) and largemouth bass (Micropterus salmoides) and compared fish collected from a reference site (Conneaut Creek). Seasonal analysis was necessary to distinguish differences in fish between the two rivers. Overall BB from the Ashtabula River had a lower condition factor and significantly more macrophage aggregates than those from the reference site. Reduced bactericidal and cytotoxic-cell activity was observed in anterior kidney leukocytes from both BB and largemouth bass from the Ashtabula River. Lower plasma thyroxine and triiodo-L-thyronine in both species in the Ashtabula River indicated disruption of the thyroid axis. Differences in physiological biomarker responses were supported by body burden chemical concentrations when data were analyzed on a seasonal basis. The use of two fish species added a level of rigor that demonstrated biological effects were not exclusive to a single species. The results provide strong evidence that contaminants have affected fish in the Ashtabula River, a Great Lakes Area of Concern, and provide a baseline by which to evaluate remediation activities.

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Section: Discussionmentioning

confidence: 97%

Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

et al. 2011

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“…Parallel studies also reported that macrophage functions can be modulated by different classes of environmental contaminants [12,13]. The majority of studies conducted under each context have been focused on the response to single stimuli, immune or xenobiotic, and studies addressing the combined action of these two stressors are limited.…”

Section: Introductionmentioning

confidence: 97%

Gene expression and TNF-alpha secretion profile in rainbow trout macrophages following exposures to copper and bacterial lipopolysaccharide

Mackenzie

Boltaña

Callol

et al. 2011

Fish & Shellfish Immunology

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“…It has been reported that arsenic exposure causes perturbation of defence systems in zebrafish [21,22], Clarius batrachus [23,24] and Sparus aurata [25]. However, reports are meager on commercially important species like the Indian major carps (IMCs) Catla catla, L. rohita, and Cirrhinus mrigala which are the main aquacultured species in the Indian subcontinent and contribute a major chunk (~87%) of the total aquaculture production [26].…”

Section: Introductionmentioning

confidence: 97%

Immunomodulatory effect of arsenic on cytokine and HSP gene expression in Labeo rohita fingerlings

Banerjee

Mitra

Purohit

et al. 2015

Fish & Shellfish Immunology

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Chronic exposure to low concentration of arsenic is immunotoxic to fish: Role of head kidney macrophages as biomarkers of arsenic toxicity to Clarias batrachus

Cited by 117 publications

References 52 publications

Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River

Gene expression and TNF-alpha secretion profile in rainbow trout macrophages following exposures to copper and bacterial lipopolysaccharide

Immunomodulatory effect of arsenic on cytokine and HSP gene expression in Labeo rohita fingerlings

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