Chronic hepatitis B: dynamic change in Traditional Chinese Medicine syndrome by dynamic network biomarkers

Lu, Yi‐Yu; Fang, Zhaoyuan; Zeng, Tao; Li, Meiyi; Chen, Qilong; Zhang, Hui; Zhou, Qian-Mei; Hu, Yiyang; Chen, Luonan; Su, Shi‐Bing

doi:10.1186/s13020-019-0275-4

Cited by 19 publications

(12 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the four cytokines, IL-4 and INF- γ showed statistical significance not only between the syndromes but also among the syndromes and healthy group, and these two cytokines may have potential as the biochemical indicators of the two TCM-syndromes. In addition, the results also demonstrated that almost all the cytokines were expressed much higher in LDSDS than in SSDHS, and this suggested that the immune response may be more intense in LDSDS than in SSDHS, and this result was also consistent with Lu et al (2019) [ 11 ].…”

Section: Discussionsupporting

confidence: 87%

“…[ 26 ]. TCM syndrome plays an important role in TCM treatment, and the same disease with different TCM syndromes in western medicine could receive different treatments in TCM [ 11 ]. However, due to the fact that TCM-syndrome is overrelying on experience, this greatly limits its application worldwide.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, TCM treatments for some chronic diseases, such as cancer and CHB, especially when combined with western medicine, could produce incredible effects [ 8 , 9 ]. TCM-syndrome, which is also called “ZHENG” in Mandarin Chinese, is the basic unit and the main perspective in TCM, which could help us understand the body homeostasis and provide guidance for the treatment of diseases [ 10 , 11 ]. In some Asian countries, TCM based on syndrome has been used to diagnose and guide the treatment of CHB for many years [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study on the Expression Differences and the Correlation with H2BE Gene of Th Related Cytokines in SSDHS and LDSDS TCM-Syndromes of CHB Patients

Liu

Zheng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Although our previous studies revealed that H2BE exhibited significantly differential expression between two CHB TCM-syndromes: Spleen-stomach dampness-heat syndrome, SSDHS and liver-depression spleen-deficiency syndrome, LDSDS, the underlying mechanisms remain largely unknown. Recent studies showed that dynamic expression fluctuation of Th related cytokines in CHB TCM-syndromes, and furthermore, their expression levels were largely regulated by H2BE. This study aims to detect the expression level differences of Th related cytokines between these two TCM-syndromes and further investigate the underlying regulatory mechanisms. The expression levels of the four Th related cytokines and H2BE were analyzed and the protein-protein interaction networks between H2BE and the four cytokines were constructed. Our results suggested that almost all the cytokines were significantly upregulated compared with the healthy group P < 0.05 . Interestingly, among the four cytokines, only IL-4 and INF-γ showed statistical significance between these two syndromes. The protein-protein interaction networks demonstrated that H2BE was indirectly associated with IL-4 and IL-10, and H2BE may regulate the expression levels of cytokines through GATA3. Taken together, our results indicated that IL-4 and INF-γ are two representative cytokines that may serve as two potential biochemical indicators of SSDHS and LDSDS in CHB patients; except what has been reported, our study found that one possible way for H2BE to regulate the expression of cytokines is to interact with GATA3 directly or indirectly.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Study on the Expression Differences and the Correlation with H2BE Gene of Th Related Cytokines in SSDHS and LDSDS TCM-Syndromes of CHB Patients

Liu

Zheng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Recently, several studies have observed relations between recurrent pregnancy loss and FXII deficiency. The results showed that plasminogen and coagulation FXII were significantly expressed during the development of TCM syndrome from liver-gallbladder dampness-heat syndrome to liver-kidney yin-deficiency syndrome ( Lu et al, 2019 ). The contact activation system is initiated upon binding of FXII to negatively charged surfaces such as artificial chemicals like kaolin or ellagic acid, or of natural origin, such as polyphosphates, 2 collagen, 3 and nucleic acids ( Visser et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Factor XII deficiency in asymptomatic Saudi population: A retrospective cohort study

AlQahtany

Algahtani

Alshebly

et al. 2021

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Factor XII (FXII) deficiency is a rare genetic blood disorder. It can lead to a higher risk of developing deep vein thrombosis or acquired thrombotic disorders than the general population. This retrospective study evaluated patients who opted for surgery and were found to have abnormal clotting profiles and clotting factors on preoperative routine blood. Patients were included regardless of whether they were symptomatic or asymptomatic. The cohort comprised 115 patients with a mean FXII level of 128.04 ± 36.93%. Two (1.79%) patients, both of whom were women, had FXII levels <60%. The mean FXII level was 58 ± 1.41 (range, 57–59%) in this group. The present study shows the prevalence of FXII in the asymptomatic Saudi population. The results provide the normal range for FXII. The findings of our study provide the basis for diagnosing F XII deficiency in the asymptomatic Saudi population.

show abstract

“…According to TCM theory and clinical experience, CHB patients are likely to be infected with a damp heat virus, which can lead to liver and gallbladder dysfunction, such as liver depression and spleen deficiency, which in turn causes disease (8,9). TCM has a number of advantages in the treatment of CHB.…”

Section: Discussionmentioning

confidence: 99%

The therapeutic effects and mechanisms of Long Chai Fang on chronic hepatitis B

Xu¹,

Wang²,

Zheng³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Long Chai Fang (LCF) is a traditional Chinese medicine (TCM) formula for treating chronic hepatitis B (CHB) in clinical settings; however, its related mechanism remains unclear.Methods: To address this issue, network pharmacology and an integrative method that combines dotblot hybridization and metabolomics analysis were employed. Network pharmacology was performed to investigate the material basis and potential mechanisms of LCF against CHB. The effect of LCF on Duck hepatitis B virus (DHBV) replication was evaluated. The metabolomics analysis was conducted to identify potential biomarkers in duck serum. Results:The network pharmacology approach revealed 133 potential active components, 897 drug targets, 979 disease targets, and 185 drug-disease targets, while the Kyoto Encyclopedia of Genes and Genomes enrichment analysis identified 165 pathways. LCF significantly inhibited DHBV-deoxyribonucleic acid replication on day 10 and day 3 after the cessation of treatment. Notably, the low-dose LCF group showed the best inhibitory effect. The obviously sustained anti-DHBV activity of LCF inhibited viral replication, and a rebound reaction was found. Phosphatidylcholine and phosphatidylethanolamine classes, which are mainly involved in liver cell repair and energy metabolism through phospholipid metabolic pathways, were identified by metabolomics analysis.Conclusions: our results showed that the main active ingredients of LCF appear to be metacarpi, isorhamnetin, glypallichalcone, and phaseolinisoflavan. This study provides novel strategies for using a LCF formula against CHB in future research.

show abstract

Chronic hepatitis B: dynamic change in Traditional Chinese Medicine syndrome by dynamic network biomarkers

Cited by 19 publications

References 53 publications

Study on the Expression Differences and the Correlation with H2BE Gene of Th Related Cytokines in SSDHS and LDSDS TCM-Syndromes of CHB Patients

Study on the Expression Differences and the Correlation with H2BE Gene of Th Related Cytokines in SSDHS and LDSDS TCM-Syndromes of CHB Patients

Factor XII deficiency in asymptomatic Saudi population: A retrospective cohort study

The therapeutic effects and mechanisms of Long Chai Fang on chronic hepatitis B

Contact Info

Product

Resources

About