Chronic hepatitis B virus infection status is more prevalent in patients with type 2 diabetes

Abstract

Aims/IntroductionIt has not been reported whether chronic hepatitis B virus infection (CHB) is associated with a specific type of diabetes. We sought to investigate the prevalence of CHB status in different diabetes subtypes among a Chinese population.Materials and MethodsThis was a cross‐sectional study. A total of 381 patients with adult‐onset autoimmune diabetes, 1,365 patients with type 2 diabetes and 1,365 non‐diabetic controls were recruited from June 2005 to February 2014. The exclusion criteria included: (i) hepatitis C virus antibody positive; (ii) hepatic cirrhosis; and (iii) malignant neoplasm and severe renal dysfunction (serum creatinine >450 μmol/L). Patients were grouped as hepatitis B virus‐negative and CHB status.ResultsPatients with type 2 diabetes had a higher prevalence of CHB than the controls in the overall population (13.5 vs 10.0%, P = 0.004) and among patients with normal hepatic function (13.3 vs 8.8%, P = 0.002). There was no difference in the prevalence of CHB status between patients with adult‐onset autoimmune diabetes and the controls. Multiple logistic regression analysis showed that the odds ratio of CHB increased by ~1.5‐fold in patients with type 2 diabetes than in the control group after adjustment for age, sex and body mass index, regardless of hepatic function status.Conclusions CHB status was more prevalent in patients with type 2 diabetes than in individuals with adult‐onset autoimmune diabetes and the controls among the Chinese population. Further research is required to ascertain whether CHB status increases the risk of developing type 2 diabetes, or whether type 2 diabetes, but not adult‐onset autoimmune diabetes, increases the risk of CHB.

The Prevalence and Risk Factors of Type II Diabetes Mellitus Among Patients with Hepatitis B Virus: A Descriptive Correlational Study

“…Therefore, the risk of HBV infection in the former group was 1.5 times higher than the latter group (18). Some studies have also confirmed the higher prevalence of DM among diabetic patients.…”

“…Previous studies on patients with hepatitis have also shown significant differences between diabetic and nondiabetic individuals regarding the mean ALT level (18,21), mean age, cirrhosis (23), mean BMI, AST, ALT, HbA1c, cholesterol, and triglyceride (24). Another study on patients with HBV showed that diabetic patients had a significantly higher mean age (47.4 vs. 57 years) and BMI (28.4 vs. 34.5 kg/m 2 ), compared to nondiabetic individuals (25).…”

Does chronic hepatitis B infection have an impact on fasting blood glucose levels and fatty liver development?

“…IR is regarded as the main cause for MS and FL development and characterized by hindered insulin-mediated glucose utilization in target tissues. More studies show that IR and its related diabetes are more prevalent in chronic HBV infection [17][18][19][20]. This study's goal was to compare FBG levels and the development of FL between the control group and the CAHB group, in terms of IR.…”

Identification of hub‐methylated differentially expressed genes in patients with gestational diabetes mellitus by multi‐omic WGCNA basing epigenome‐wide and transcriptome‐wide profiling

“…For exogenous antibodies, hepatitis B surface antigen positivity during pregnancy has a moderate effect on an increased risk of GDM . Moreover, the pathophysiological mechanism by which HBV (hepatitis B virus) infection causes diabetes is characterized as a metabolic disorder due to decreased liver function . GDM has been reported to be related to the upregulation of circulating inflammatory factors .…”