Chronic hepatitis induced by Jin Bu Huan

Picciotto, Antonino; Campo, N.; Brizzolara, R.; Giusto, R; Guido, Gianluca; Sinelli, Nicoletta; Lapertosa, G; Celle, G

doi:10.1016/s0168-8278(98)80217-1

Cited by 81 publications

(42 citation statements)

References 7 publications

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“…Its active ingredient is a , recently this herbal drug was also found to induce chronic hepatitis after a period as short as 1 year of intake. In the latter patient, focal hepatocellular necrosis and moderate ®brosis had developed and it remains speculative whether prolonged treatment would have even lead to cirrhosis and liver failure 18 . Another single agent preparation that emerged as liver toxic in the literature is the ephedrine-containing Chinese herb product Ma-Huang 19 .…”

Section: Chinese Herbal Medicinementioning

confidence: 99%

Hepatotoxicity of botanicals

Stickel

Egerer

Seitz

2000

Public Health Nutr.

133

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Objective: Hepatic impairment resulting from the use of conventional drugs is widely acknowledged, but there is less awareness of the potential hepatotoxicity of herbal preparations and other botanicals, many of which are believed to be harmless and are commonly used for self-medication without supervision. The aim of this paper is to examine the evidence for hepatotoxicity of botanicals and draw conclusions regarding their pathology, safety and applications. Design: Current literature on the hepatotoxicity of herbal drugs and other botanicals is reviewed. The aetiology, clinical picture and treatment of mushroom (Amanita) poisoning are described.

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Section: Chinese Herbal Medicinementioning

confidence: 99%

Hepatotoxicity of botanicals

Stickel

Egerer

Seitz

2000

Public Health Nutr.

133

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“…Jin Bu Huang is a common Chinese herb that used as analgesic, sedative and sleeping aid (30). However, JBH has been associated with acute and chronic hepatitis (105,107). Accordingly, the active component of JHB is the extract from Lypocodium serratum plant (94,106).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, all the patients recovered after discontinuation of herbal preparations. Another hepatotoxic effect of JBH involved a 49-year-old male diagnosed with chronic hepatitis as well as moderate fibrosis after ingestion of three tablets of JBH per day (107).…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

Hepatotoxic Botanicals - An Evidence-based Systematic Review

Abdualmjid

Sergi

2013

J Pharm Pharm Sci

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-Purpose. Herbal medicines have been increasingly used worldwide. However, the potential harms of these herbs have been noticed most recently following hepatotoxicity with ingestion of herbal remedies. The aim of this review is to evaluate the evidence of hepatotoxic effects linked to use of herbal preparations. Method. Electronic search was performed by searching several databases: PubMed, HerbMed, Google Scholar, Scopus, Cochrane Database of Systematic Reviews and Cochrane Library using both Latin and common names of several herbs. Language was restricted to English and articles were selected for relevance reporting incidence of hepatotoxicity associated with use of herbal products in human. Results. From a total of 565 relevant reviews and articles, 254 met our inclusion criteria and were analyzed.

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“…Modern pharmaceutical practices have made it available worldwide as a single pure chemical of high therapeutic potency [40]. In recent years, toxic effects, including depression of neurological, respiratory, and cardiac function in pediatric poisonings, as well as acute or chronic hepatitis after regular use in adults, have been reported by several authors [41][42][43][44][45]. Very recently Li et al (2006) reported comparative studies of the similarities and differences between the microbial and mammalian metabolisms of L-THP, the microbial transformation by Penicillium janthinellum, and metabolism in rats [46].…”

Section: Palmatine Analogsmentioning

confidence: 99%