Chronic hyperglycemia as a risk factor in implant therapy

Javed, Fawad; Romanos, Georgios E.

doi:10.1111/prd.12283

Cited by 53 publications

(43 citation statements)

References 50 publications

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“…Furthermore, some studies have reported that hyperglycemia can inhibit epithelium cell proliferation and migration. These phenomena may inhibit wound healing and lead to the formation of wounds [35]. The three types support and protect each other.…”

Section: Discussionmentioning

confidence: 99%

PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities

et al. 2020

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Background: Diabetic wounds are a disturbing and rapidly growing clinical problem. A novel peptide, parathyroid hormone related peptide (PTHrP-2), is assumed as multifunctional factor in angiogenesis, fibrogenesis and reepithelization. This study aims to test PTHrP-2 efficiency and mechanism in wound healing. Methods: Through repair phenomenon in vivo some problems were detected, and further research on their mechanisms was made. In vivo therapeutic effects of PTHrP-2 were determined by HE, Masson, microfil and immunohistochemical staining. In vitro direct effects of PTHrP-2 were determined by proliferation, migration, Vascular Endothelial Grown Factor and collagen I secretion of cells and Akt/ Erk1/2 pathway change. In vitro indirect effects of PTHrP-2 was study via exosomes. Exosomes from PTHrP-2 untreated and treated HUVECs and HFF-1 cells were insolated and identified. Exosomes were co-cultured with original cells, HUVECs or HFF-1 cells, and epithelial cells. Proliferation and migration and pathway change were observed. PTHrP-2-HUVEC-Exos were added into in vivo wound to testify its hub role in PTHrP-2 indirect effects in wound healing. Results: In vivo, PTHrP-2 exerted multifunctional pro-angiogenesis, pro-firbogenesis and re-epithelization effects. In vitro, PTHrP-2 promoted proliferation and migration of endothelial and fibroblast cells, but had no effect on epithelial cells. Therefore, we tested PTHrP-2 indirect effects via exosomes. PTHrP-2 intensified intercellular communication between endothelial cells and fibroblasts and initiated endothelial-epithelial intercellular communication. PTHrP-2-HUVEC-Exos played a hub role in PTHrP-2 indirect effects in wound healing.Conclusion: These findings of this study indicated that PTHrP-2, a multifunctional factor, could promote wound healing via synergistic multicellular stimulating and exosomal activities.

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Section: Discussionmentioning

confidence: 99%

PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities

et al. 2020

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“…Other factors influencing the healing and prognosis of dental implants, such as smoking and diabetes mellitus, have been extensively discussed in the literature and have also been reported in the present volume of Periodontology 2000 by Javed et al. Tobacco smoking and habitual use of nicotine‐related products, as environmental risk factors in implant therapy, and the effect of nicotine on osseointegration, have been also discussed .…”

Section: Systemic Factors Affecting Implant Prognosismentioning

confidence: 78%

Concepts for prevention of complications in implant therapy

Romanos

Delgado-Ruíz

Sculean

2019

Periodontology 2000

Self Cite

109

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| INTRODUC TI ONDental implant therapy is a well-established dental treatment modality that provides benefits for edentulous and partially edentulous patients. Edentulism is a toothless condition that affects well-being and life quality. Although the prevalence of complete tooth loss has declined since 2002, edentulism remains a major disease worldwide, especially among older adults. 1 According to several studies, tooth loss can affect general health in a number of ways owing to reduced intake of a vitamin-rich diet. 2 Also, it has been demonstrated that the dentition status can impact the healthy eating index score and overall diet quality. 3 Edentulism is significantly associated with depression and poor self-rated health in patients younger than 50 years. 4 Furthermore, in a recent systematic review that evaluated mortality and the rehabilitation of edentulism, a possible relationship was found between death rate and edentulousness, in that death rate was higher among edentulous patients not using dentures compared with denture wearers. 5 Therefore, oral health-care providers should prevent tooth loss with proper dental education and improved treatment quality to rehabilitate the edentulous and partially edentulous patients and reestablish proper masticatory function.Dental implants are a valuable treatment option for improving oral health and quality of life, especially for completely edentulous patients. 6 However, dental implants can fail at different points in time, starting from the moment when they are inserted. Based on the time when the failure occurred and the time of loading, early and late failures have been described. 7 However, implant therapy also can present complications, which do not necessarily lead to implant failure.Therefore, the aim of this volume of Periodontology 2000 is to present an overview on the causes of various types of complications related to implant therapy and to provide the practitioner with clinical concepts on their prevention and management. | BONE DYNAMI C AC TIVIT Y FROM TIME OF IMPL ANT PL ACEMENTThe dental implant treatment process starts with comprehensive planning, followed by surgical management of the alveolar bone to prepare it to receive primary (mechanically) stable implant(s) and implant restoration(s) that are resistant to occlusal loads and meet the functional and esthetic demands of patients. However, complications (biological, surgical, or prosthetic) may be encountered. During surgery, strong dynamic and active processes are present in peri-implant tissues, which are induced by trauma during flap and periosteum elevation at the time of implant insertion and the response of the surrounding tissues to the implant material (ie, titanium). The peri-implant bone density is altered (modified) as a result of bone removal (osteotomy) and subsequent bone condensation (ie, through the use of osteotomes or osseodensification, or undersizing of the osteotomy), and bone density continues to improve by stimulating the surrounding bone using functional loading. This st...

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“…These phenomena may inhibit wound healing and lead to the formation of wounds (35). The three types support and protect each other.…”

Section: Discussionmentioning

confidence: 99%

PTH Derivative Promotes Wound Healing via Synergistic Multicellular Stimulating and Exosomal Activities

Shen

Huang

Wang

et al. 2020

Preprint

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Background: Diabetic wounds are a disturbing and rapidly growing clinical problem. A novel peptide, parathyroid hormone related peptide (PTHrP-2), is assumed as multifunctional factor in angiogenesis, fibrogenesis and re-epithelization. This study aims to test PTHrP-2 efficiency and mechanism in wound healing. Methods: Through repair phenomenon in vivo some problems were detected, and further research on their mechanisms was made. In vivo therapeutic effects of PTHrP-2 were determined by HE, Masson, microfil and immunohistochemical staining. In vitro direct effects of PTHrP-2 were determined by proliferation, migration, Vascular Endothelial Grown Factor and collagen I secretion of cells and Akt/ Erk1/2 pathway change. In vitro indirect effects of PTHrP-2 was study via exosomes. Exosomes from PTHrP-2 untreated and treated HUVECs and HFF-1 cells were insolated and identified. Exosomes were co-cultured with original cells, HUVECs or HFF-1 cells, and epithelial cells. Proliferation and migration and pathway change were observed. PTHrP-2-HUVEC-Exos were added into in vivo wound to testify its hub role in PTHrP-2 indirect effects in wound healing. Results: In vivo, PTHrP-2 exerted multifunctional pro-angiogenesis, pro-firbogenesis and re-epithelization effects. In vitro, PTHrP-2 promoted proliferation and migration of endothelial and fibroblast cells, but had no effect on epithelial cells. Therefore, we tested PTHrP-2 indirect effects via exosomes. PTHrP-2 intensified intercellular communication between endothelial cells and fibroblasts and initiated endothelial-epithelial intercellular communication. PTHrP-2-HUVEC-Exos played a hub role in PTHrP-2 indirect effects in wound healing. Conclusion: These findings of this study indicated that PTHrP-2, a multifunctional factor, could promote wound healing via synergistic multicellular stimulating and exosomal activities. Key words PTH, multifunctional factor, diabetic wound, exosomes, synergistic effect

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Chronic hyperglycemia as a risk factor in implant therapy

Cited by 53 publications

References 50 publications

PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities

PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities

Concepts for prevention of complications in implant therapy

PTH Derivative Promotes Wound Healing via Synergistic Multicellular Stimulating and Exosomal Activities

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