Chronic Inflammatory Demyelinating Polyneuropathy after Treatment with Interferon-.ALPHA.

Abstract

Interferon-α (IFN-α)

Chronic Inflammatory Demyelinating Polyneuropathy Due to the Administration of Pegylated Interferon .ALPHA.-2b: A Neuropathology Case Report

“…On the other hand, autoimmunity is a well-recognized complication of IFNα therapy, with reported frequencies ranging between 4.3% and 18.5% in large observational studies (3)(4)(5). Neuropathies due to administration of IFNα are a rare complication (3,4); however, eight distinct case reports have shown that chronic inflammatory demyelinating polyneuropathy (CIDP) can result from administration of IFNα, presumably due to perturbations in the host immune system (6)(7)(8)(9)(10)(11)(12)(13). We here report a biopsy-proven case with IFNα-induced CIDP in which the serum value of tumor necrosis factor-α (TNFα) was elevated.…”

Guillain-Barre syndrome associated with peginterferon alfa-2a for chronic hepatitis C: A case report

“…GBS associated with peginterferon alfa2a for CHC [6][7][8][9]11] . We did not test for IFN antibodies (that could possibly cross-react), did not rule out all the GBS related infectious causes definitely and did not check autoimmune markers at the time of onset of neurological symptoms.…”

“…Significant neurological side effects such as nerve palsy and peripheral neuropathy are rare [6] . A few cases of Bell' s Palsy and chronic inflammatory demyelinating po-lyneuropathy (CIDP) and even one case of acute demyelinating polyneuropathy (AIDP) with atypical features for Guillain-Barre syndrome (GBS) associated with Interferon therapy have been reported, but no report of GBS with typical features has been published [5][6][7][8][9] . We present a case report of GBS that developed at wk 8 of therapy with Peginterferon alfa-2a.…”

Polineuropatia desmielinizante inflamatória crônica pós-tratamento com interferon peguilado alfa 2b em um paciente co-infectado HIV/HCV: relato de caso

“…A polineuropatia desmielinizante inflamatória crônica associa-se muitas vezes com doenças virais, como vírus da imunodeficiência humana (HIV) e o vírus da hepatite C (HCV) 1 . Muito recentemente, não apenas o agente viral, mas também o tratamento com imunomoduladores, como o interferon peguilado alfa (INFα), tem sido correlacionado com surgimento de PDIC 2,3 . Este relato de caso refere-se a um paciente imunodeprimido com síndrome da imunodeficiência adquirida (SIDA) e HCV que evoluiu com PIDC secundária ao uso de INFα2b, com excelente resposta à terapia com imunoglobulina humana hiperimune (IHH).…”

“…Apesar de ser uma reação adversa pouco comum, outros casos na literatura vem demonstrando essa associação 2,3,7,10 , e o fato da estavudina poder ter concorrido para este quadro representa mais um alerta aos médicos que tratam pacientes co-infectados HIV/HCV, para as possíveis toxicidades concomitantes das medicações usadas.…”