Chronic kidney disease in children as seen in a tertiary hospital in Enugu, South-East, Nigeria

Odetunde, Odutola Israel; Okafor, HU; Uwaezuoke, Samuel N; Ezeonwu, BU; Kd, Adiele; Ukoha, OM

doi:10.4103/1119-3077.127553

Cited by 27 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This value is comparable to 14.9 per MARP reported by Odetunde et al in the earlier study done in the same center [15]. The prevalence obtained in this study is lower compare to the reports from Chilean survey of 42.5 per MARP [16] Jordan report of 51 per MARP [1,17], Italian Italkid project of 74.7 per MARP [18] and United States renal data system (USRDS) report of 82 per MARP 1,7 and could be explained by the fact that these studies were extensively done to obtain data all over the index country from both the hospital-based and outright population-based studies with wide spread coverage giving a better representation of the country's population unlike the skewed coverage of this hospital-based study.…”

Section: Discussionsupporting

confidence: 78%

“…However, a few other studies noted more of acute pericarditis with effusion than thickening in children, especially in those on haemodialysis [23,42]. It was documented that acute pericarditis and the resultant pericardial effusion is associated with uremia and hypervolemia, especially in patients with insufficient dialysis and ultra-filtration, as seen commonly among children with CKD in the West African sub region [15,43]. The pericardial effusion may occasionally be resistant to dialysis requiring surgical drainage [23,42].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Echocardiographic Findings in Children with Chronic Kidney Disease as Seen in a Resource -Limited Setting

Adiele¹,

Okafor²,

Ojinnaka³

et al. 2014

J Nephrol Ther

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Echocardiographic Findings in Children with Chronic Kidney Disease as Seen in a Resource -Limited Setting

Adiele¹,

Okafor²,

Ojinnaka³

et al. 2014

J Nephrol Ther

View full text Add to dashboard Cite

show abstract

“…Limited information exists concerning the feasibility of performing HD in young children in low‐resource settings, and the few papers that have been published emphasized the difficulties in performing HD in the young child, citing factors such as technical issues, high costs, or limited expertise . PD is the preferred modality for initiating RRT in the small child .…”

Section: Discussionmentioning

confidence: 99%

Audit of Hemodialysis in Children Weighing Less than 20 kg in an African Pediatric Nephrology Unit

et al. 2018

View full text Add to dashboard Cite

Peritoneal dialysis and kidney transplantation remain the preferred choices for renal replacement therapy in young children. These options, however, are not always feasible, and hemodialysis (HD) is therefore an accepted alternative. In small children presenting with end-stage renal disease, HD presents several challenges and is often unavailable in lower- and middle-income countries. To assess these challenges and outcomes of maintenance HD in young children, we performed an audit of children below 20 kg with end-stage renal disease, receiving HD for ≥4 weeks, from 1 January 2008 to 31 July 2016 at the Red Cross War Memorial Children's Hospital. We identified 15 children weighing 6.8-18.5 kg (mean 12.9 kg ±3.5 SD) and aged 11.5-105 months (mean 52.2 months±4.2 SD) at HD initiation. Mean duration of HD was 11.8 months (range 1-61.5 months ± 16.9 SD). Seven children underwent successful transplantation, two patients died, and four currently still receive HD. Two patients, while on HD, relocated to other centers. An average of 2.6 (range 1-5) different vascular accesses was required per patient. Technical difficulties were the most common cause of central-line removal (81%), while catheter-associated bacteremia was 1.1/1000 catheter days. Frequent problems were intradialytic hypotension, growth stunting, and interdialytic hypertension. HD in lower- and middle-income countries is feasible in small children but presents with certain challenges. Advocacy with lobbying for funding and development of "child-friendly" dialysis equipment and specialized centers with highly skilled personnel are the cornerstones of successful pediatric HD programs in less-resourced centers.

show abstract

“…Childhood nephrotic syndrome has a reported incidence of 2 to 7 cases per 100,000 children and a prevalence of nearly 16 cases per 100,000. [1,2] In Tropical Africa, NS is an important cause of chronic kidney disease (CKD) [3][4][5][6] and the incidence of NS as a cause of childhood CKD may be as high as 45% [4] but the exact prevalence of childhood nephrotic syndrome in this region is not known. Olowu et al [7] in a comprehensive comparative review on childhood NS found that among the 45 African countries in Tropical Africa, only 11 countries, representing 53.9% of the population of the region, have information on the burden of childhood NS indicating substantial underreporting.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy and Safety of Levamisole in African Children With Idiopathic Nephrotic Syndrome: A Protocol for Systematic Review and Meta-Analysis

Akwaowo¹,

Nna²,

Okafor³

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundNephrotic syndrome (NS) is one of the most common childhood renal disorders globally, with an incidence of 2 to 7 cases per 100,000 children. A characteristic feature is massive proteinuria which may rapidly progress to end stage kidney failure, if uncontrolled. Most of the cases in children are steroid sensitive but associated with frequent relapses. Levamisole, a cheap antihelminthic has been used as steroid sparing agent in steroid sensitive NS (SSNS). This study assesses the efficacy and safety of Levamisole in African children with idiopathic nephrotic syndrome.MethodsWe will conduct a systematic review and meta-analysis of all Randomised controlled trials which reported African children with Idiopathic nephrotic syndrome who were on Levamisole compared to other drugs. Ten databases including PubMed, African Journals Online, Google Scholar, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Cochrane Library, Web of Science, Scopus, Clinicaltrial.gov and Research Gate will be searched using a search strategy. The search will have no time restrictions, but studies must have been conducted among African children residing in Africa and are retrievable in the English Language. Studies will be selected based on inclusion and exclusion criteria by two independent reviewers without blinding. The study quality will be assessed using the Pedro scale and risk of bias evaluated using the Cochrane Risk of Bias tool. Eligible screened studies will be inlcuded for meta-analysis using the CMA Software. Statistical, clinical and methodological heterogeneity will be tested. Subgroup analyses and meta-regression will be performed on rate of relapses, adverse event and drug dose.DiscussionThe primary outcome will be the proportion of children with remissions and or relapses within 6 -12 months post initiation of levamisole or comparators with effect size being the relative risk. Safety of Levamisole will be measured using reported adverse events. Moderating effects of age, gender, duration of illness, and dosage of Levamisole on the duration of remission, frequency of relapses and adverse events will be examined.Systematic Review RegistrationThis protocol has been registered in PROSPERO, with registration number CRD42020213327.

show abstract

Chronic kidney disease in children as seen in a tertiary hospital in Enugu, South-East, Nigeria

Abstract: CKD in children poses myriad of challenges in management in our setting with late presentation of patients and limited resources being prominent. The majority of patients could not access and sustain RRT and the outcome continues to be daunting.

Cited by 27 publications

References 15 publications

Echocardiographic Findings in Children with Chronic Kidney Disease as Seen in a Resource -Limited Setting

Echocardiographic Findings in Children with Chronic Kidney Disease as Seen in a Resource -Limited Setting

Audit of Hemodialysis in Children Weighing Less than 20 kg in an African Pediatric Nephrology Unit

The Efficacy and Safety of Levamisole in African Children With Idiopathic Nephrotic Syndrome: A Protocol for Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About