Chronic kidney disease predictors in obese adolescents

Maćkowiak-Lewandowicz, Katarzyna; Ostalska‐Nowicka, Danuta; Zaorska, Katarzyna; Kaczmarek, Elżbieta; Zachwieja, Jacek; Witt, Martin; Nowicki, Michał

doi:10.1007/s00467-021-05403-2

Cited by 11 publications

(6 citation statements)

References 49 publications

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“…Maćkowiak-Lewandowicz et al . also found that in obese individuals with normal or reduced eGFR, increased concentrations of NGAL in urine together with increase cholesterol, triglycerides and uric acid may be predictors for CKD development [ 22 ]. Our material shows that only children in the obese group and in the subgroup with MS had significantly higher concentrations of non-HDL-C and triglycerides than children in the control group.…”

Section: Discussionmentioning

confidence: 99%

Lipid metabolism and renal function markers in obese adolescents

Radosz¹,

Obuchowicz²

2023

pedm

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Aim of the study: To investigate the relationship of renal function markers and lipid metabolism parameters in obese adolescents. Material and methods: The study comprised 76 children aged 11-17 years, hospitalised due to: obesity (group I -19 children) or obesity accompanied by obesity-induced hypertension (group II -30 children) or normosthenic children with a diagnosed tension headaches (control group -27 children). A subgroup with metabolic syndrome (MS -16 children) was also separated. Renal function was assessed on the basis of: serum creatinine concentration, glomerular filtration rate estimated using Schwartz eqation (eGFR), determination of plasma and urinary neutrophil gelatinase-associated lipocalin and cystatin C. On the basis of statistical analysis, it was checked whether renal function markers depend on lipid metabolism parameters. Results: In the study groups mean creatinine concentrations were significantly higher and eGFR values significantly lower than in the control group, but they remained within norm. Differences in plasma and urinary neutrophil gelatinase-associated lipocalin concentrations were not significant. Mean cystatin C concentrations were significantly higher in the group of obese children. Multiple linear regression analysis showed that the most important predictor was: LDL-C for urinary neutrophil gelatinase-associated lipocalin (R2 = 0.42) and TG for eGFR (R2 = 0.44) concentrations in group I; cholesterol for creatinine concentrations in MS group (R2 = 0.44). Conclusions: Renal function of the obese adolescents included in the study was normal and the associations with lipid metabolism were poorly expressed.

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Section: Discussionmentioning

confidence: 99%

Lipid metabolism and renal function markers in obese adolescents

Radosz¹,

Obuchowicz²

2023

pedm

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“…Serum concentrations of TNF-α (Abcam, United States, ab181421) ( 25 ), IL-6 (Abcam, United States, ab178013) ( 26 ), IL-18 (Abcam, United States, ab215539) ( 27 ), and adiponectin (Abcam, United States, ab99968) ( 28 ) were measured using highly sensitive and specific ELISA kits according to the manufacturer’s instructions. These kits demonstrated no significant cross-reactivity.…”

Section: Methodsmentioning

confidence: 99%

Serum levels of Vanin-2 increase with obesity in relation to inflammation of adipose tissue and may be a predictor of bariatric surgery outcomes

Geng,

Chen,

Wang

et al. 2023

Front. Nutr.

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ObjectiveExcessive obesity can lead to dysfunction in adipose tissue, which contributes to the development of comorbidities associated with obesity, such as type 2 diabetes (T2D), cardiovascular and cerebrovascular disease, among others. Previous research has mainly focused on the Vanin family in systemic inflammatory diseases or predicting its role in tumor prognosis, while neglecting its role as a secretory protein in adipose tissue inflammation and metabolism. The objective of this study was to compare the changes in Vanin-2 levels in the circulating blood of normal and obese individuals, and to assess its correlation with inflammatory factors in vivo. Furthermore, the study aimed to systematically evaluate its effectiveness in human weight loss surgery.MethodsSerum concentrations of Vanin-2 and inflammatory indicators were measured in 518 volunteers. Furthermore, the concentrations of Vanin-2 were measured both before and after weight loss through a dietetic program or laparoscopic sleeve gastrectomy (LSG). Additionally, we assessed the levels of insulin, adiponectin, and inflammation-related factors. The hormonal profile and changes in body weight were evaluated at baseline and 3 months after surgery.ResultsSerum levels of Vanin-2 were found to be significantly increased in individuals with overweight/obesity (OW/OB) group (controls 438.98 ± 72.44, OW/OB 530.89 ± 79.39 ug/L; p < 0.001). These increased levels were associated with IL-18, BMI, FAT%, and HOMA-IR. However, levels of Vanin-2 remained unchanged after conventional dietary treatment. On the other hand, weight loss induced by LSG resulted in a significant decrease in Vanin-2 concentrations from 586.44 ± 48.84 to 477.67 ± 30.27 ug/L (p < 0.001), and this decrease was associated with the Vanin-2 concentrations observed before the operation.ConclusionSerum Vanin-2 is a highly effective biomarker for assessing adipose tissue inflammation in obesity and has the potential to serve as a predictor of bariatric surgery outcomes.

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“…On the other hand, Polidori et al found both higher mean serum cystatin C and urine NGAL in obese prepubertal children (17) . A study in obese adolescents showed a correlation between eGFR and an increased urinary NGAL (28) . In our patients, although no significant difference was found in mean plasma NGAL levels, the correlation analysis for the combined groups showed weak positive correlations of these levels with creatinine and negative correlations with eGFR.…”

Section: Groupmentioning

confidence: 98%

An assessment of renal function by neutrophil lipocalin and cystatin C in obese adolescents with or without obesity-induced hypertension

Radosz¹,

Obuchowicz²

2023

Pediatr Med Rodz

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Introduction: Obesity and hypertension are associated with organ complications, including kidney diseases. It is necessary to search for the methods of early detection of these complications. Aim: The aim of the study was to assess renal function in obese adolescents, based on lipocalin-2 and cystatin C levels in relation to creatinine, estimated glomerular filtration rate and leptin levels. Materials and methods: The study included 76 children aged 11–17 years, with obesity or with obesity and obesity- induced hypertension or normosthenic children with tension headaches (control group). Renal function was assessed based on serum creatinine and estimated glomerular filtration rate (Schwartz equation). Plasma and urine lipocalin-2, serum cystatin C and leptin levels were determined by ELISA. Results: Renal function assessed by creatinine level and estimated glomerular filtration rate was normal in all patients, but mean creatinine levels were significantly higher and estimated glomerular filtration rate was significantly lower in the study groups compared to controls. No significant differences were found in plasma and urine lipocalin-2 levels. Mean cystatin C level was significantly higher in the obese group. We have found a weak positive correlation between plasma lipocalin-2 and creatinine levels and its weak negative correlation with estimated glomerular filtration rate, as well as a positive correlation for leptin and cystatin C levels in the obese group. Conclusion: The role of plasma and urine lipocalin-2 and serum cystatin C in the assessment of renal function in obese adolescents with or without obesity-induced hypertension is ambiguous. The relationship between cystatin C and leptin levels in obese children also requires further research.

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Chronic kidney disease predictors in obese adolescents

Cited by 11 publications

References 49 publications

Lipid metabolism and renal function markers in obese adolescents

Lipid metabolism and renal function markers in obese adolescents

Serum levels of Vanin-2 increase with obesity in relation to inflammation of adipose tissue and may be a predictor of bariatric surgery outcomes

An assessment of renal function by neutrophil lipocalin and cystatin C in obese adolescents with or without obesity-induced hypertension

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