Chronic Lymphoid Leukæmia.

Panton, P.N.; Valentine, F.C.O.

doi:10.1016/s0140-6736(00)79186-0

Cited by 13 publications

(3 citation statements)

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“…A high incidence of CLL was reported in Connecticut USA, in the United Kingdom and in Yugoslavia against the low incidence in Poland and Hungary [9]. CLL was reported to occur fre quently in the Jewish population of Brooklyn [16] as well as in other countries [21]. A high incidence of leukemia was also reported in the Jewish population of Israel [6].…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of CLL was reported to be low in Far-Eastern, African and South American populations and high among Caucasians [27,32]. The Jewish population in various countries was also reported to have a high incidence of the disease [16,21]. These observations drew attention to the racial and ethnic distribution of this disease in the understanding of its etiology.…”

Section: Introductionmentioning

confidence: 99%

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Ethnical and Clinical Aspects of Chronic Lymphocytic Leukemia in Israel

Bartal¹,

Bentwich²,

Manny³

et al. 1978

Acta Haematol

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The ethnic distribution of 288 patients with chronic lymphocytic leukemia (CLL) from five medical centers in Israel during the decade 1960–1970 was investigated as well as other features of the disease. 80.5% of the patients were of East European descent, 14.5% originated from Asia and Africa and 5% were born in Israel. Based on the ethnic distribution of the elderly population of Israel during the above period, it is suggested that CLL occurs more frequently in European-born Jews than in Asian and African Jews. A low occurrence of Coombs positive hemolytic anemia was revealed, amounting to 7.2% of the patients. Of 68 patients who underwent serum immunoglobulin studies, up to 74% exhibited deficiency of at least one type of immunoglobulin. Low levels of IgA were encountered in 61.2%, IgM in 51.5% and IgG in 29.5% of the patients. 26 of 206 patients with CLL (12.5%), all of East European origin, had an additional primary malignant tumor, cancer of the skin and breast being the most frequent associated malignancies. In 6 patients of the 26, two additional neoplasms were diagnosed. Hypogammaglobulinemia was more frequent in patients with additional primary malignant tumors and in patients with advanced disease. The possible causes for the ethnic distribution of CLL in Israel as well as of other tumors are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnical and Clinical Aspects of Chronic Lymphocytic Leukemia in Israel

Bartal¹,

Bentwich²,

Manny³

et al. 1978

Acta Haematol

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“…and in chronic myelogenous leukzmia in 30 per cent. Panton and Valentine (1929) found normal red cells in over half their cases of chronic lymphatic leukaemia but Wintrobe and Hasenbush (1939) state that anaemia is more likely to be present early in this disease than in the myelogenous form. Our figures agree with this latter view.…”

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confidence: 99%