Nowadays manifestation of atherosclerosis of mesenteric vessels increases with the growth of cardiovascular pathology. The actual problems of the chronic and acute mesenteric ischemia, its diagnosis and treatment effectiveness were analyzed and considered on the basis of a literature review. Etiopathogenesis, clinical manifestations, diagnostic approaches, treatment strategies including conservative and surgical treatment were considered in this article. The absence of common programs of diagnosis and treatment directs scientific and clinical search with using modern material and technical possibilities.