Chronic neutrophilic leukemia

Bredeweg, Arthur; Burch, Micah; Krause, John R.

doi:10.1080/08998280.2017.1400300

Cited by 1 publication

(6 citation statements)

References 12 publications

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“…As shown in Table 1, two CNL‐MGUS patients with SETBP1 mutations reported in case 4 and case 5 all had blastic evolution during follow‐up treatment with hydroxyurea and died soon after 4 . After 1 month of ruxolitinib treatment for case 7, repeat NGS suggested clonal evolution by new mutations for SRSF2 and RUNX1 detected, and two previously mutated genes ( CSF3R and SETBP1 ) disappeared 6 …”

Section: Discussionmentioning

confidence: 91%

“…23 However, a meta-analysis that included 3 reports totaling 56 cases of CNL indicated that the SETBP1 mutation had no unfavorable effect on the prognosis of CNL. 30 As shown in acquired new gene mutations during the follow-up process, 6 and the 2 patients reported in cases 4 and 5 had blastic evolution during the treatment process, 4 indicating that CNL-PCD will undergo clonal evolution or blastic evolution. However, whether CNL-PCD is the same as isolated CNL with similarities in clonal evolution or blastic evolution needs to be expanded for further analysis.…”

Section: Discussionmentioning

confidence: 96%

“… 4 After 1 month of ruxolitinib treatment for case 7, repeat NGS suggested clonal evolution by new mutations for SRSF2 and RUNX1 detected, and two previously mutated genes ( CSF3R and SETBP1 ) disappeared. 6 …”

Section: Discussionmentioning

confidence: 99%

“…Here, the clinical data of a patient with chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance (CNL‐MGUS) in our hospital were analyzed. At the same time, 10 cases of CNL complicated with plasma cell disorder (CNL‐PCD) and 1 case of CNL complicated with lymphocytic proliferative disease (CNL‐LPD) with gene detection were searched from PubMed and the Chinese database CNKI 1–10 …”

Section: Introductionmentioning

confidence: 99%

“…At the same time, 10 cases of CNL complicated with plasma cell disorder (CNL‐PCD) and 1 case of CNL complicated with lymphocytic proliferative disease (CNL‐LPD) with gene detection were searched from PubMed and the Chinese database CNKI. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 We analyzed the molecular biological characteristics of these cases with the hope of further improving our understanding of this disease.…”

Section: Introductionmentioning

confidence: 99%

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Chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance: A case report and literature review

Gao

Zhai

Gao

et al. 2022

Clinical Laboratory Analysis

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Background Study of the molecular biological characteristics of chronic neutrophilic leukemia complicated with plasma cell disorder (CNL‐PCD) and lymphocytic proliferative disease (CNL‐LPD). Methods The clinical data of a patient with chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance (CNL‐MGUS) in our hospital were reviewed, and the Chinese and/or English literature about CNL‐PCD and CNL‐LPD in PubMed and the Chinese database CNKI in the past 10 years was searched to analyze the molecular biological characteristics of this disease. Results A 73‐year‐old male had persistent leukocytosis for 18 months. The white blood cell count was 46.77 × 109/L and primarily composed of mature neutrophils; hemoglobin: 77 g/L; platelet count: 189 × 109/L. Serum immunofixation electrophoresis showed IgG‐λ monoclonal M protein. A CT scan showed splenomegaly. Next‐generation sequencing (NGS) showed that CSF3R T618I, ASXL1 and RUNX1 mutations were positive. It was diagnosed as CNL‐MGUS. We summarized 10 cases of CNL‐PCD and 1 case of CNL‐LPD who underwent genetic mutation detection reported in the literature. The CSF3R mutational frequency (7/11, 63.6%) was lower than that of isolated CNL. The ASXL1 mutations were all positive (3/3), which may represent a poor prognostic factor. The SETBP1 mutation may promote the progression of CNL‐PCD. We also found JAK2, RUNX1, NRAS, etc. in CNL‐PCD. Conclusions Chronic neutrophilic leukemia may be more inclined to coexist with plasma cell disorder. The CSF3R mutation in CNL‐PCD is still the most common mutated gene compared with isolated CNL. Mutations in SETBP1 and ASXL1 may be poor prognostic factors for CNL‐PCD.

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Section: Discussionmentioning

confidence: 91%