Chronic obstructive pulmonary disease among lung cancer-free smokers: The importance of healthy controls

Karpman, Michelle D.; Eldridge, Ronald C.; Follis, Jack L.; Etzel, Carol J.; Shete, Sanjay; El‐Zein, Randa

doi:10.1016/j.resinv.2017.11.002

Cited by 7 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within nonsmokers, CA patients had the highest survival rate, compared with AA patients (89.47% vs. 57.14%). These findings are consistent with other studies showing that cigarette smoking can induce lung cancer and impair patients' survival (1,24,25). Our results further reveal survival differences between AA and CA patients with different smoking histories.…”

Section: Smoking Contributes To Differences In Survival and Immune Pr...supporting

confidence: 93%

See 1 more Smart Citation

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

Zhang

Thaiparambil

et al. 2022

Cancer Research Communications

View full text Add to dashboard Cite

Tumors accumulated with infiltrated immune cells (hot-tumors) have a higher response rate to immune checkpoint blockade, when compared to those with minimal T cell infiltration (cold-tumors). We report here that lung cancer patients with different racial backgrounds harbored distinct immune cell profiles in the tumor microenvironment. Compared to African Americans (AAs), Caucasian Americans (CAs) exhibited increased immune cell infiltration and vasculature, and increased survival. Changes of survival and immune profile were most pronounced among active smokers and non-smokers, compared to former smokers and total patients. Neighborhood analysis showed that immune cells accumulated around cancer cells in CAs but not AAs. Our findings reveal intrinsic biological differences between AA and CA lung cancer patients, suggesting that treatment plans should be tailored for patients with different racial backgrounds.

show abstract

Section: Smoking Contributes To Differences In Survival and Immune Pr...supporting

confidence: 93%

“…Smoking is known as the leading contributor to lung cancer survival (1,24,25). We found significant differences of survival immune profile between AA and CA patients with different smoking histories (Fig.…”

Section: Discussionmentioning

confidence: 65%

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

Zhang

Thaiparambil

et al. 2022

Cancer Research Communications

View full text Add to dashboard Cite

show abstract

“…Independently, environmental exposure has contributed to 20% of COPD patients. There is also consistent evidence that smoking cessation lowers the risk of mortality due to COPD (Karpman et al, 2018).…”

Section: Smoking Habitmentioning

confidence: 87%

Chronic obstructive pulmonary disease: Signs and symptoms, diagnosis, treatments, lifestyle risk factors and management

Lim,

Ulaganathan,

Gunasekaran

et al. 2024

LSMB

View full text Add to dashboard Cite

Chronic Obstructive Pulmonary Disease (COPD) is associated with increased health complications, leading to a rise in mortality rates. COPD remains a significant global health issue, underscoring the importance of recognizing symptoms, facilitating diagnosis, and implementing effective treatment strategies. However, information on lifestyle risk factors and the management of COPD remains fragmented. This review paper aims to understand the clinical pathophysiologic changes triggered by lifestyle practices and their management strategies. It is important to understand its symptoms, diagnostics criteria, and treatment to correlate with lifestyle risk factors and to identify effective lifestyle interventions. Lifestyle practices as defined by dietary practices such being anorexia and low fruit and vegetable intake, smoking habits, alcohol consumption, and physical inactivity have increased the risk of COPD. This review suggested lifestyle approaches for COPD treatment such as regular exercise, a healthy diet, and avoiding smoking. In this case, the development of the guided improved intervention is important for a better understanding of the mechanisms between COPD and its associated lifestyle practices. This information may help clinicians, health practitioners, and dietitians to guide patients to implement improved dietary interventions. To avoid the progression of COPD, lifestyle practice therapy could be the most effective strategies that aid with medications as prescribed by the physicians.

show abstract

“…It is well-recognized that ARDS is the major symptom of COVID-19 infection that may cause mortality [ 111 ]. Respiratory distress can also be caused by smoking and air pollution, both of which are associated with increased DNA damage in lung cells and/or peripheral blood leukocytes [ [112] , [113] , [114] ]. Evidence is emerging that exposure to air pollution increases the risk of COVID-19 infection, suggesting a 2-hit hypothesis that the combination of exposure to airborne genotoxins and COVID-19 virus further aggravates susceptibility to virus replication and lung inflammation [ 111 , [115] , [116] , [117] ].…”

Section: Vicious Cycles Of Rna Virus Infection Micronucleus Formation and Inflammationmentioning

confidence: 99%

Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis

Kirsch‐Volders

Fenech

2021

Mutation Research/Reviews in Mutation Research

View full text Add to dashboard Cite

In this review we bring together evidence that (i) RNA viruses are a cause of chromosomal instability and micronuclei (MN), (ii) those individuals with high levels of lymphocyte MN have a weakened immune response and are more susceptible to RNA virus infection and (iii) both RNA virus infection and MN formation can induce inflammatory cytokine production. Based on these observations we propose a hypothesis that those who harbor elevated frequencies of MN within their cells are more prone to RNA virus infection and are more likely, through combined effects of leakage of self-DNA from MN and RNA from viruses, to escalate pro-inflammatory cytokine production via the cyclic GMP–AMP synthase (cGAS), stimulator of interferon genes (STING) and the Senescence Associated Secretory Phenotype (SASP) mechanisms to an extent that is unresolvable and therefore confers high risk of causing tissue damage by an excessive and overtly toxic immune response. The corollaries from this hypothesis are (i) those with abnormally high MN frequency are more prone to infection by RNA viruses; (ii) the extent of cytokine production and pro-inflammatory response to infection by RNA viruses is enhanced and possibly exceeds threshold levels that may be unresolvable in those with elevated MN levels in affected organs; (iii) reduction of MN frequency by improving nutrition and life-style factors increases resistance to RNA virus infection and moderates inflammatory cytokine production to a level that is immunologically efficacious and survivable.

show abstract

Chronic obstructive pulmonary disease among lung cancer-free smokers: The importance of healthy controls

Cited by 7 publications

References 25 publications

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

Chronic obstructive pulmonary disease: Signs and symptoms, diagnosis, treatments, lifestyle risk factors and management

Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis

Contact Info

Product

Resources

About