Chronic obstructive pulmonary disease and cerebrovascular disease: A comprehensive review

Lahousse, Lies; Tiemeier, Henning; Ikram, M. Arfan; Brusselle, Guy

doi:10.1016/j.rmed.2015.07.014

Cited by 109 publications

(74 citation statements)

References 142 publications

(114 reference statements)

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“…Chronic smoking is also involved in the production of pathogenic changes (decrease in the gray matter density) in areas where Alzheimer's disease develops (inferior parietal lobule and precuneus). Moreover, its deleterious action can continue even after smoking cessation [57][58][59].…”

Section: Copd: Fundamental Pathophysiological Mechanisms Susceptible mentioning

confidence: 99%

Neurocognitive Impairment as Systemic Effects of COPD

Oancea¹,

Tudorache²,

Tudorache³

2018

COPD - An Update in Pathogenesis and Clinical Management

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Mild cognitive impairment (MCI), also known as incipient dementia, is characterized by the decline of cognitive function greater than expected for a certain age and educational level of the individual but not severe enough to interfere with their daily activities. However, this mild cognitive impairment afects several areas: visuospatial, memory, atention and luency and it is a signiicant concern because it decreases the quality of life and treatment adherence of these patients. On the other hand, evidence suggests that individuals with Chronic obstructive pulmonary disease (COPD) also present an important risk of falls: 46% of these patients experience a fall/year, sometimes with fatal consequences. Standard clinical balance measures can predict the risk of falls in this population. Moreover, increased inlammatory biomarkers are associated with the decrease of cognitive functions and a higher risk of falls in this population. Patients with COPD have a higher balance and cognitive impairment than their healthy peers Therefore, it is important to identify, assess and understand the relevance of these comorbidities in order to characterize the full clinical spectrum of COPD and adjust prevention strategies, given the devastating consequences of these problems.

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Section: Copd: Fundamental Pathophysiological Mechanisms Susceptible mentioning

confidence: 99%

Neurocognitive Impairment as Systemic Effects of COPD

Oancea¹,

Tudorache²,

Tudorache³

2018

COPD - An Update in Pathogenesis and Clinical Management

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“…Increasing age is the most significant determinant of cognitive impairment,7 besides a history of tobacco smoking8 and a low educational level 9. Although the exact pathogenesis of cognitive impairment in COPD remains unknown, vascular-mediated brain pathology, oxidative stress, hypoxemia, systemic inflammation, and comorbidities are proposed pathways to cognitive impairment 1,2,10,11…”

Section: Introductionmentioning

confidence: 99%

Domain-specific cognitive impairment in patients with COPD and control subjects

Cleutjens

Franssen

Spruit

et al. 2016

COPD

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Impaired cognitive function is increasingly recognized in COPD. Yet, the prevalence of cognitive impairment in specific cognitive domains in COPD has been poorly studied. The aim of this cross-sectional observational study was to compare the prevalence of domain-specific cognitive impairment between patients with COPD and non-COPD controls. A neuropsychological assessment was administered in 90 stable COPD patients and 90 non-COPD controls with comparable smoking status, age, and level of education. Six core tests from the Maastricht Aging Study were used to assess general cognitive impairment. By using Z-scores, compound scores were constructed for the following domains: psychomotor speed, planning, working memory, verbal memory, and cognitive flexibility. General cognitive impairment and domain-specific cognitive impairment were compared between COPD patients and controls after correction for comorbidities using multivariate linear and logistic regression models. General cognitive impairment was found in 56.7% of patients with COPD and in 13.3% of controls. Deficits in the following domains were more often present in patients with COPD after correction for comorbidities: psychomotor speed (17.8% vs 3.3%; P<0.001), planning (17.8% vs 1.1%; P<0.001), and cognitive flexibility (43.3% vs 12.2%; P<0.001). General cognitive impairment and impairments in the domains psychomotor speed, planning, and cognitive flexibility affect the COPD patients more than their matched controls.

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“…COPD is a common respiratory disease among elderly. While there is clinical and epidemiologic evidence of cerebral small vessel disease, stroke, TIAs, and (vascular) cognitive impairment in patients with COPD 45,46 , literature is very scarce on the presence of lung function abnormalities and/or COPD in patients with stroke or TIA, and/or dementia. Patients with stroke have several concomitant chronic diseases, and > 20% have COPD 47 .…”

Section: Stroke and Transient Ischaemic Attacksmentioning

confidence: 99%

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

Beghè¹,

Clini²,

Fabbri³

2017

BRN

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Two-thirds of people aged ≥65 years have multi-morbidity. Multi-morbidity includes both physical and mental health conditions, as anxiety and depression, that almost invariably affect patients with multiple symptomatic chronic diseases. Management of a patient with any of the chronic diseases that are part of multi-morbidity is not just the management of that single index disease, but must include the active search and proper treatment of concomitant chronic diseases. The presence of concomitant chronic diseases should not alter the management of the index disease (e.g., chronic obstructive pulmonary disease [COPD]), and concomitant chronic diseases should be treated according to single diseases guidelines regardless of the presence of the index disease, obviously with careful consideration that this choice implies complex management, polypharmacy and potential adverse effects. Preliminary management programs suggest that a holistic integrated approach might improve quality of life and reduce hospital admissions and death in these multimorbid patients. (BRN Rev. 2017;3:247-66)

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Chronic obstructive pulmonary disease and cerebrovascular disease: A comprehensive review

Cited by 109 publications

References 142 publications

Neurocognitive Impairment as Systemic Effects of COPD

Neurocognitive Impairment as Systemic Effects of COPD

Domain-specific cognitive impairment in patients with COPD and control subjects

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

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