Chronic Obstructive Pulmonary Disease – Chaperonopathology

Cherneva, Radostina; Петрова, Даниела; Georgiev, Ognian

doi:10.5772/30389

Cited by 1 publication

(1 citation statement)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous work showed that elevated αB-crystalline (hspB5) can be found both in non-small-cell lung cancer patients and COPD patients 19. In the present study, we confirmed the tissue expression of αB-crystalline in bronchial biopsies of COPD smokers.…”

Section: Discussionsupporting

confidence: 88%

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis

Cherneva¹,

Georgiev²,

Петрова³

et al. 2012

COPD

Self Cite

View full text Add to dashboard Cite

BackgroundαB-crystallin (HspB5) is a chaperone whose role as a marker of innate immunity activation as well as its therapeutic potential have recently been investigated in several inflammatory diseases: multiple sclerosis, myocardial ischemia, and Guillain–Barré syndrome.AimThe aim of this study is to determine the role of αB-crystallin in chronic obstructive pulmonary disease (COPD) pathogenesis and inflammation.MaterialsPlasma levels of αB-crystallin were studied in 163 patients: 52 healthy non-COPD smokers; 20 COPD smokers in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I–II; 43 COPD smokers in GOLD stages III-IV. Forty-eight patients were diagnosed with acute inflammatory respiratory disease. The plasma levels of αB-crystallin antibodies were determined by an enzyme-linked immunosorbent assay (Calbiochem), and were confirmed with Western blotting. Tissue expression of the protein was compared in three different groups of patients: COPD smokers, COPD nonsmokers, and in patients with age-related emphysema.ResultsThe mean level of anti-αB-crystallin antibodies in non-COPD smokers was 0.291nm. In COPD smokers it was 0.352 nm and, in patients with inflammatory lung diseases, 0.433 nm. There was a statistically significant difference between COPD smokers and healthy non-COPD smokers (P = 0.010). The same could be observed comparing the group of patients with acute inflammation and non-COPD healthy smokers (P = 0.007). There was no statistically significant difference between patients with mild/moderate inflammation and those with severe COPD. Tissue detection of the protein showed that it was significantly overexpressed in COPD smokers in comparison to COPD nonsmokers and was only slightly expressed in patients with age-related emphysema.ConclusionαB-crystallin is increased in patients with inflammatory lung diseases. Though unspecific, it could be used in a panel of markers discerning COPD smokers from healthy nonsmokers. As αB-crystallin is a regulator of innate immunity and a therapeutic anti-inflammatory agent, its exact role in COPD pathogenesis and therapy should be explored further.

show abstract

Section: Discussionsupporting

confidence: 88%

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis

Cherneva¹,

Georgiev²,

Петрова³

et al. 2012

COPD

Self Cite

View full text Add to dashboard Cite

show abstract

Chronic Obstructive Pulmonary Disease – Chaperonopathology

Cited by 1 publication

References 120 publications

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis

Contact Info

Product

Resources

About

Chronic Obstructive Pulmonary Disease – Chaperonopathology

Cited by 1 publication

References 120 publications

The role of small heat-shock protein &alpha;B-crystalline (HspB5) in COPD pathogenesis

The role of small heat-shock protein &alpha;B-crystalline (HspB5) in COPD pathogenesis

Contact Info

Product

Resources

About

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis