Chronic Otitis Media and Mastoiditis Due to Proteus Vulgaris (Bacillus Proteus)

McGovern, Francis H.; Khuri, Afif A.

doi:10.1001/archotol.1958.00730010413004

Cited by 9 publications

(2 citation statements)

References 13 publications

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“…Moreover, the gram‐positive organisms are usually more often sensitive to the most commonly prescribed antibiotics for OM, leading to an increase of gram‐negative organisms. Some older studies have also posited that more virulent flora, such as Streptococcus pneumoniae , lead to a more fulminant suppurative meningitis, while species such as Proteus and Pseudomonas are more likely to be associated with a more indolent infection with bone erosion, chronic otitis media with or without cholesteatoma, and, rarely, intracranial abscess formation . Finally, anaerobic bacteria likely play a role in these infections, but are difficult to isolate due to challenges in culturing.…”

Section: Discussionmentioning

confidence: 99%

“…Some older studies have also posited that more virulent flora, such as Streptococcus pneumoniae, lead to a more fulminant suppurative meningitis, while species such as Proteus and Pseudomonas are more likely to be associated with a more indolent infection with bone erosion, chronic otitis media with or without cholesteatoma, and, rarely, intracranial abscess formation. 43 Finally, anaerobic bacteria likely play a role in these infections, but are difficult to isolate due to challenges in culturing. Indeed, studies that include specific techniques to culture anaerobes, such as Hafidh et al, demonstrated that anaerobes were the most commonly cultured organism from otogenic abscesses.…”

Section: Discussionmentioning

confidence: 99%

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Otogenic brain abscesses: A systematic review

Duarte

Kozin

Barshak

et al. 2018

Laryngoscope Investig Oto

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ObjectiveOtogenic brain abscesses are one of the most significant life‐threatening complications of otologic infections. Given their low prevalence, otogenic brain abscesses require a high index of suspicion for diagnosis. In this systematic review, we aim to provide an analysis of otogenic brain abscesses and describe common clinical signs and symptoms, bacteriology, location, treatment options, morbidity, and mortality.Data SourcesPubMed, Cochrane CENTRAL database, Google Scholar, and Scopus.MethodsA systematic review of literature was performed using the Preferred Reporting Items for Systematic Reviews and Meta‐analyses recommendations. Variables assessed included clinical signs and symptoms, bacteriology, location, treatment, morbidity, and mortality.ResultsTwenty‐nine studies met inclusion and exclusion criteria, corresponding to a total of 1307 otogenic abscess cases for review. Fifty‐five percent of abscesses were found in the temporal lobe and 28% in the cerebellum. Most patients (88.3%) had a history of suppurative chronic otitis media. The most common symptoms were headache, altered mental status, papilledema, and meningeal irritation. Fever, nausea, and vomiting affected about 40% of patients. The most commonly cultured bacterial species was Proteus mirabilis. In addition to antibiotics, most otogenic brain abscesses were treated by burr hole aspiration. Average mortality following advent of computed tomography was 8.11%.ConclusionAlthough rare, otogenic brain abscesses may occur as a complication of suppurative otitis media and require a high index of suspicion. Appropriate imaging studies and multidisciplinary expertise are crucial in the diagnosis and management.Level of Evidence4.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%