Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone

Abstract

ObjectiveTo explore the potential damaging effect of chronic pelvic inflammation on ovarian reserve.DesignCase-control study.PatientsA total of 122 women with bilateral tubal occlusion, diagnosed by hysterosalipingography (HSG) and 217 women with normal fallopians were recruited.MeasurementsSerum anti-Mullerian hormone (AMH), basic follicle-stimulating hormone (FSH), luteining hormone (LH), estradiol (E2), and testosterone (T) were measured; and antral follicle counts (AFCs) were recorded.ResultsSignificantly lower level of AMH was observed in women with bilateral tubal occlusion compared to control group [2.62 (2.95) ng/ml vs. 3.37 (3.11) ng/ml, P = 0.03], and the difference remained after adjustment of BMI (Padjust = 0.04). However, no statistical difference was found in the levels of FSH [7.00 (2.16) IU/L vs. 6.74 (2.30) IU/L], LH [4.18 (1.52) IU/L vs. 4.63 (2.52) IU/L], E2 [35.95 (20.40) pg/ml vs. 34.90 (17.85) pg/ml], T [25.07±11.46 ng/dl vs. 24.84±12.75 ng/dl], and AFC [6.00 (4.00) vs. 7.00 (4.00)] between two groups (p>0.05).ConclusionsWomen with bilateral tubal occlusion showed decreased AMH level, suggesting that chronic pelvic inflammation may diminish ovarian reserve. More caution should be paid when evaluating the detriment of PID on female fertility.

Symposium review: Mechanisms of disruption of fertility by infectious diseases of the reproductive tract

“…During inflammatory processes activation of phosphoinositol 3 kinase (PI3K) results in conversion of phosphoinositol diphosphate to phosphoinositol triphosphate, with activation of protein kinase B (PKB, also known as AKT), which happens to be the pathway by which quiescent primordial follicles are activated to leave the resting pool and embark on development to ultimate atresia or ovulation . This observation seems to have clinical relevance because women with chronic pelvic inflammation experience depletion of the ovarian reserve (Cui et al, 2016). Depletion of primordial follicles not only shortens reproductive lifespan, but also may affect fertility at normal reproductive age.…”

Short Term Alterations of Hormone Profile Following Oocyte Pick-Up in Women with Polycystic Ovarian Syndrome to Assess the Effect of Multiple Needle Entries Into the Ovarian Cortex and Stroma

“…In addition to the tissue destruction by mechanical needle insertion, pathophysiological mechanisms may also include the consequences of inflammatory responses to multiple needle entries supported by the previous data showed deleterious effect of chronic inflammation on the ovarian reserve (28). There are some studies published in the literature that showed elevated serum testosterone levels and insulin resistance following ovarian stimulation (29,30).…”

Сучасні Підходи До Етіопатогенезу, Діагностики Та Лікування Гнійно-Запальних Захворювань Органів Малого Таза (Огляд Літератури)

“…Це порушує анатомічне взаєморозміщення і здатне згодом підтримувати запальний процес (Brunha� �.C. et al, 2015;Cui L. et al, 2016;Зиганшин А.М., Мудров В.А., 2019;Huang C.-C. et al, 2019). Оклюзія фаллопієвих труб є найчастішим ускладненням ЗЗОМТ, що викликає 42,3% жіночого безпліддя (Cui L. et al, 2016).…”