Chronic periodontitis and implant dentistry

Smith, Michael; Knight, Ellie T.; Al-Harthi, Latfiya; Leichter, Jonathan W.

doi:10.1111/prd.12190

Cited by 42 publications

(40 citation statements)

References 72 publications

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“…S. sanguinis has also been shown to form biofilm on different dental implant surfaces [ 33–35 ]. It is worth noting that the incidence of peri-implant complications significantly increases in patients with periodontitis [ 36 ]. Several studies demonstrate that plaque formation on dental implants results in peri-implant mucositis [ 37 , 38 ].…”

Section: Characteristics Of Streptococcus Sanguinismentioning

confidence: 99%

Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens

et al. 2018

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Caries and periodontitis are the two most common human dental diseases and are caused by dysbiosis of oral flora. Although commensal microorganisms have been demonstrated to protect against pathogens and promote oral health, most previous studies have addressed pathogenesis rather than commensalism. Streptococcus sanguinis is a commensal bacterium that is abundant in the oral biofilm and whose presence is correlated with health. Here, we focus on the mechanism of biofilm formation in S. sanguinis and the interaction of S. sanguinis with caries- and periodontitis-associated pathogens. In addition, since S. sanguinis is well known as a cause of infective endocarditis, we discuss the relationship between S. sanguinis biofilm formation and its pathogenicity in endocarditis.

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Section: Characteristics Of Streptococcus Sanguinismentioning

confidence: 99%

Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens

et al. 2018

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“…Dental implants are regularly placed in patients with a history of periodontitis, even though peri‐implant tissues are susceptible to the same host‐modulated plaque‐induced factors that initiate and sustain periodontitis . In the chapter ‘Chronic periodontitis and implant dentistry’, the evidence relating to a history of periodontitis as a risk factor for implant success and survival, and the role of supportive periodontal therapy in maintaining implants for individuals with a history of periodontitis, are discussed.…”

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confidence: 99%

Interdisciplinary periodontics: the multidisciplinary approach to the planning and treatment of complex cases

Lyons¹,

Darby²

2017

Periodontology 2000

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Periodontics cannot be practiced in isolation as frequently many patients have multiple dental needs or medical health issues requiring management. In addition, pathology may manifest in the periodontal tissues, and the onset and progression of periodontitis can be affected by systemic conditions, such as diabetes, and vice versa. The focus of this volume of Periodontology 2000 is interdisciplinary periodontics, and the articles included discuss the interactions and the interrelationshipbetween periodontal tissues/periodontal diseases and endodontics, fixed prosthodontics, implant dentistry, esthetics, gerodontology, radiology, orthodontics, pediatric dentistry, oral and maxillofacial surgery, oral pathology, special needs dentistry and general medicine. Previous volumes of Periodontology 2000 have covered some of the interactions between periodontal diseases and other dental disciplines, especially implant dentistry, 'and the interaction between periodontal disease and systemic disease', but there has not been a volume on interdisciplinary periodontics. The intention therefore is to show how and why periodontics should be interdisciplinary, as well as the benefits of an interdisciplinary approach; in addition, the potential consequences of using a discipline in isolation are discussed.

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“…The typical symptom of periodontitis is the destruction or loss of the supportive tissues of teeth [31].…”

Section: Discussionmentioning

confidence: 99%

Klotho inhibits H 2 O 2 -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression

Zhu

Xie

Liu

et al. 2020

Preprint

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Background Periodontitis, known as a human chronic inflammatory disease, has affected the life of millions of individuals. Known risk factors such as metabolic disease and oxidative stress have been reported to be closely associated with the initiation or development of periodontitis. However, the etiology of periodontitis remains unclear. Klotho, a single-pass transmembrane protein, has been widely reported to modulate cellular processes in various diseases. However, the role of Klotho in periodontitis is unknown.Results In this study, we designed and conducted a series of experiments to evaluate the role of Klotho in chronic periodontitis. Our experimental results showed that Klotho was downregulated in the gingival tissues, gingival crevicular fluid (GCF), and periodontal ligament stem cells (PDLSCs) of chronic periodontitis patients. Besides, Klotho upregulated the production of uncoupling protein 2 (UCP2) in H2O2-treated PDLSCs. In function, Klotho inhibited H2O2-induced oxidative stress and cellular apoptosis in PDLSCs. Moreover, the rescue assay suggested that UCP2 knock-down suppressed the effects of Klotho on H2O2-induced oxidative stress and apoptosis in PDLSCs.Conclusions In conclusion, we found that Klotho inhibits H2O2-induced oxidative stress and apoptosis in PDLSCs by regulating UCP2 expression. This novel discovery may provide a potential target for chronic periodontitis treatment.

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Chronic periodontitis and implant dentistry

Cited by 42 publications

References 72 publications

Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens

Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens

Interdisciplinary periodontics: the multidisciplinary approach to the planning and treatment of complex cases

Klotho inhibits H 2 O 2 -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression

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