Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma

Tezal, Miné; Sullivan, Maureen; Hyland, Andrew; Marshall, James R.; Stoler, Daniel L.; Reid, Mary E.; Loree, Thom R.; Rigual, Néstor R.; Merzianu, Mihai; Hauck, Linda; Lillis, Cheryl; Wactawski‐Wende, Jean; Scannapieco, Frank A.

doi:10.1158/1055-9965.epi-09-0334

Cited by 285 publications

(265 citation statements)

References 49 publications

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“…Some evidence also exists for an association between oral squamous cell carcinoma and the presence of dento-gingival bacterial plaques and chronic periodontitis [36]. However, a direct cause and effect relationship between chronic periodontitis and cancer has not been shown and the role of inflammation as the single cause for cancerous transformation in such cases has not been proven yet [35].…”

Section: The Invasion-metastasis Cascadementioning

confidence: 99%

Metastatic Tumors to the Jaws and Mouth

Hirshberg

Berger

Allon

et al. 2014

Head and Neck Pathol

160

171

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Metastatic dissemination to the oral cavity is rare and is usually the evidence of a wide spread disease with an average survival rate of 7 months. In almost a quarter of the cases, oral metastasis was found to be the first indication of an occult malignancy at a distant site. Metastatic lesions can be found anywhere in the oral cavity, however, the jawbones with the molar area is the most frequently involved site. In the oral soft tissues, the gingiva is the most common site, suggesting the possible role of inflammation in the attraction of metastatic deposits. The most common primary malignancies presenting oral metastases were the lung, kidney, liver, and prostate for men, and breast, female genital organs, kidney, and colorectum for women. Most patients with jawbone metastasis complain of swelling, pain, and paresthesia. An exophytic lesion is the most common clinical presentation of metastatic lesions in the oral soft tissues. Early lesions, mainly those located in the gingiva, may resemble a hyperplastic or reactive lesion. Once a lesion is recognized as metastasis, the primary tumor site should be identified following clinical, radiological and histopathological investigations. If standardized diagnostic workup fails to detect the site of origin, then the term carcinoma of unknown primary is applied. Personalized medicine tools such as tissue-oforigin assays should be applied, either by immunohistochemical testing or by molecular-profiling methods as these may lead to a more favorable outcome.

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Section: The Invasion-metastasis Cascadementioning

confidence: 99%

Metastatic Tumors to the Jaws and Mouth

Hirshberg

Berger

Allon

et al. 2014

Head and Neck Pathol

160

171

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“…À ce titre, toute lésion exophytique ou ulcération péri-implantaire chez de tels patients doit être considérée comme suspecte jusqu'à preuve du contraire et toute péri-implantite ne répondant pas à un traitement adéquat même chez le patient sain doit être biopsiée à la recherche d'une éventuelle lésion maligne [69].…”

Section: Synthèseunclassified

Implantologie et pathologies de la muqueuse buccale : une revue de la littérature

Moreau

Renoux

Ejeil

2015

Med Buccale Chir Buccale

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Résumé -Introduction : L'essor de l'implantologie au cours des dernières années a conduit à une augmentation du champ de ses indications, repoussant notamment les contre-indications liées aux terrains pathologiques des patients. Cet article propose une revue de la littérature et une mise au point sur l'implantologie dans un contexte de pathologies de la muqueuse buccale. Méthodologie : À partir d'une recherche bibliographique sur la base de données MEDLINE sans limite de période, les articles traitant de l'implantologie chez des patients atteints de pathologies de la muqueuse buccale ont été étudiés. Résultats : L'implantologie chez ces patients a été peu décrite. Les données de cette revue de la littérature tendent à mettre en évidence un apport indéniable de la mise en place d'implants chez les patients atteints de pathologies de la muqueuse buccale. Discussion : Historiquement considérées comme des contre-indications à la pose d'implants, ces pathologies ne doivent plus aujourd'hui être considérées comme un frein à une réhabilitation prothétique implanto-portée. Conclusion : Toutefois, une maintenance et une hygiène rigoureuses doit être instaurée afin de contrôler les implants et l'éventuelle réactivation de la pathologie.Abstract -Implantology and oral mucosal lesions: a literature review. Introduction: Recent developments in implantology have led to an extension of its indications, especially regarding special care patients. This paper offers a review of the literature on the subject of implantology in cases of oral mucosal lesions. Methods: A review of the literature was performed using MEDLINE, without a date range, searching for articles describing oral implant treatments in patients with oral mucosal alterations. Results: Few cases of oral implant treatments in such patients are described. The results of the literature review showed that oral implant treatments greatly enhance the quality of life of these patients. Discussion: Although these pathologies used to be considered contraindications to dental implant placement, recent data shows the feasibility of such treatments. Conclusion: Nonetheless, both strict oral hygiene and regular maintenance are essential to intercept any potential pathology reactivation.

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“…Periodontite resulta numa contínua liberação de bactérias e marcadores inflamatórios na saliva e, em menor grau, no sangue. Mais do que isso, patógenos periodontais e citocinas inflamatórias viajam com saliva e sangue para tecidos afetados à distância e adversamente afetam a saú-de sistêmica 34 . Mais importante, tratamento das infecções periodontais tem mostrado prevenir e reverter eventos adversos sistêmicos 35 .…”

Section: Interação Entre Doença Periodontal E Câncer Bucalunclassified

“…Mais importante, tratamento das infecções periodontais tem mostrado prevenir e reverter eventos adversos sistêmicos 35 . Estudos prévios sugerem que periodontite crônica pode ser associada com lesões bucais pré-malignas, câncer de língua e tumores por papiloma vírus humano (HPV) na base de língua 34 . Num estudo envolvendo 473 pacientes (266 com CCE e 207 controles), Tezal et al 34 (2009) encontraram forte associação entre doença periodontal e carcinomas bucais, sendo a força da associação maior na cavidade bucal, seguida da orofaringe e laringe.…”

Section: Interação Entre Doença Periodontal E Câncer Bucalunclassified

“…Estudos prévios sugerem que periodontite crônica pode ser associada com lesões bucais pré-malignas, câncer de língua e tumores por papiloma vírus humano (HPV) na base de língua 34 . Num estudo envolvendo 473 pacientes (266 com CCE e 207 controles), Tezal et al 34 (2009) encontraram forte associação entre doença periodontal e carcinomas bucais, sendo a força da associação maior na cavidade bucal, seguida da orofaringe e laringe. A associação persistia em pacientes que nunca usaram tabaco e álcool, mas era mais forte em fumantes.…”

Section: Interação Entre Doença Periodontal E Câncer Bucalunclassified

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Biofilmes Orais como Um Possível Fator de Risco ao Câncer Bucal

Ciesielski¹,

Biasoli²,

Goiato³

et al. 2010

Odonto

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127Biofilmes orais como um possível fator de risco ao câncer bucal Oral biofilms as a possible risk factor for oral cancerResumo Introdução: muito se estuda a respeito dos fatores de risco associados ao câncer bucal. Fatores como fumo, álcool e radiação solar já estão bem estabelecidos, porém outros, como a influência bacteriana no desenvolvimento ou progressão de uma neoplasia ainda permanecem inexplicados. O interesse na possibilidade de relação entre bactérias e diferentes estágios do desenvolvimento do câncer aumentou desde a classificação do Helicobacter pylori pela OMS como um carcinógeno definitivo. Subsequentemente, ligações entre infecções e o início de câncer em vários sítios do corpo foram descobertos.Revisão de literatura: esta revisão de literatura buscou demonstrar a influência da má higiene bucal, com consequente acúmulo bacteriano como um possível fator de risco importante ao início e desenvolvimento de neoplasias bucais, bem como correlacionar os possíveis mecanismos pelos quais as bactérias podem iniciar ou promover carcinogênese.Conclusões: existem muitas evidências de que bactérias presentes da cavidade bucal e periodontopatogênicas encontram-se presentes em tecidos neoplásicos, porém, ainda não se pode afirmar que tais bactérias iniciem ou promovam carcinogênese. Palavras-chave:Microbiologia; Câncer Bucal; Biofilme Dentário. AbstRACtIntroduction: much studies regarding risk factors associated with oral cancer. Factors such as smoking and alcohol and solar radiation are well established, but others, such as bacterial influence in the development or progression of a tumor still remain unexplained. Interest in the possible relationship between bacteria and different stages of cancer development has increased since the classification of H. pylori by the WHO as a definite carcinogen. Subsequently, links between infection and the onset of cancer in various sites in the body were discovered.Review of literature: this literature review attempts to show the influence of poor oral hygiene, with consequent bacterial accumulation as a possible important risk factor for the initiation and development of mouth cancer, and correlate the possible mechanisms by which bacteria can initiate or promote carcinogenesis. Conclusion:there is much evidence that bacteria in the oral cavity and periodontopathic are present in tumor tissue, however, still can not affirm that these bacteria initiate or promote carcinogenesis.

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Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma

Cited by 285 publications

References 49 publications

Metastatic Tumors to the Jaws and Mouth

Metastatic Tumors to the Jaws and Mouth

Implantologie et pathologies de la muqueuse buccale : une revue de la littérature

Biofilmes Orais como Um Possível Fator de Risco ao Câncer Bucal

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