Chronic Respiratory Dysfunction Due to Diffuse Alveolar Hemorrhage in Patients With Systemic Lupus Erythematosus and Primary Vasculitis

Aceves, Eva Pérez; Cristóbal, Mario Pérez; Reyna, Gerardo A. Espinola; Andraca, Raúl Ariza; Fridmann, Daniel Xibille; Fabris, Leonor Adriana Barile

doi:10.1016/j.reumae.2013.01.014

Cited by 5 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We believe this is noteworthy given that DAH can lead to organized pneumonia, collagen deposition, and pulmonary fibrosis, which in time can cause changes in pulmonary function with either restrictive or obstructive deficits. 18 We recognize that the nature of this review makes us unable to determine whether our results are representative of the general cSLE population presenting with DAH. However, our single-center experience provides a basis for further investigations, including well-designed comparative trials that may warrant pooling of data from other institutions in North America, given the rarity of this disease entity.…”

Section: Discussionmentioning

confidence: 90%

Diffuse Alveolar Hemorrhage as a Manifestation of Childhood-Onset Systemic Lupus Erythematosus

Singla

Canter

Vece

et al. 2016

Hospital Pediatrics

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 90%

Diffuse Alveolar Hemorrhage as a Manifestation of Childhood-Onset Systemic Lupus Erythematosus

Singla

Canter

Vece

et al. 2016

Hospital Pediatrics

View full text Add to dashboard Cite

show abstract

“…5 In most cases, pulmonary hemorrhage coexists with cardiac compromise or concomitant infections 4,37 and can lead to impaired respiratory function. 38…”

Section: Discussionmentioning

confidence: 99%

Pleuropulmonary involvement in patients with systemic lupus erythematosus from a Latin American inception cohort (GLADEL)

Salinas

Caeiro

Saurit

et al. 2017

Lupus

View full text Add to dashboard Cite

Objectives The objectives of this study were to examine the demographic and clinical features associated with the occurrence of pleuropulmonary manifestations, the predictive factors of their occurrence and their impact on mortality in systemic lupus erythematosus (SLE) patients. Materials and methods The association of pleuropulmonary manifestations with demographic and clinical features, the predictive factors of their occurrence and their impact on mortality were examined in GLADEL patients by appropriate univariable and multivariable analyses. Results At least one pleuropulmonary manifestation occurred in 421 of the 1480 SLE patients (28.4%), pleurisy being the most frequent (24.0%). Age at SLE onset ≥30 years (OR 1.42; 95% CI 1.10-1.83), the presence of lower respiratory tract infection (OR 3.19; 95% CI 2.05-4.96), non-ischemic heart disease (OR 3.17; 95% CI 2.41-4.18), ischemic heart disease (OR 3.39; 95% CI 2.08-5.54), systemic (OR 2.00; 95% CI 1.37-2.91), ocular (OR 1.58; 95% CI 1.16-2.14) and renal manifestations (OR 1.44; 95% CI 1.09-1.83) were associated with pleuropulmonary manifestations, whereas cutaneous manifestations were negatively associated (OR 0.47; 95% CI 0.29-0.76). Non-ischemic heart disease (HR 2.24; 95% CI 1.63-3.09), SDI scores ≥1 (OR 1.54; 95% CI 1.10-2.17) and anti-La antibody positivity (OR 2.51; 95% CI 1.39-4.57) independently predicted their subsequent occurrence. Cutaneous manifestations were protective of the subsequent occurrence of pleuropulmonary manifestations (HR 0.62; 95% CI 0.43-0.90). Pleuropulmonary manifestations independently contributed a decreased survival (HR: 2.79 95% CI 1.80-4.31). Conclusion Pleuropulmonary manifestations are frequent in SLE, particularly pleuritis. Older age, respiratory tract infection, cardiac, systemic and renal involvement were associated with them, whereas cutaneous manifestations were negatively associated. Cardiac compromise, SDI scores ≥1 and anti-La positivity at disease onset were predictive of their subsequent occurrence, whereas cutaneous manifestations were protective. They independently contributed to a decreased survival in these patients.

show abstract

“…Rarely, RA-associated vasculitis presents as diffuse alveolar hemorrhage (DAH), 85 although vasculitis is more commonly seen in SLE, affecting up to 5% of patients. 85 86 87 In SLE, DAH may also reflect bland hemorrhage occurring in the absence of vasculitis. In either case, there is frequently concurrent lupus nephritis.…”

Section: Vascular Disease In Connective Tissue Diseasesmentioning

confidence: 99%

Imaging of Lung Disease Associated with Connective Tissue Disease

Bartlett

Renzoni

Sivarasan

et al. 2022

Semin Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

Chronic Respiratory Dysfunction Due to Diffuse Alveolar Hemorrhage in Patients With Systemic Lupus Erythematosus and Primary Vasculitis

Cited by 5 publications

References 22 publications

Diffuse Alveolar Hemorrhage as a Manifestation of Childhood-Onset Systemic Lupus Erythematosus

Diffuse Alveolar Hemorrhage as a Manifestation of Childhood-Onset Systemic Lupus Erythematosus

Pleuropulmonary involvement in patients with systemic lupus erythematosus from a Latin American inception cohort (GLADEL)

Imaging of Lung Disease Associated with Connective Tissue Disease

Contact Info

Product

Resources

About