Chronic restraint increases apoptosis in the hippocampus of rats with high responsiveness to fear stimuli

Lehner, Małgorzata; Wisłowska-Stanek, Aleksandra; Skórzewska, Anna; Płaźnik, Adam

doi:10.1016/j.neulet.2014.12.011

Cited by 9 publications

(2 citation statements)

References 30 publications

(48 reference statements)

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“…This might have affected caspase-3 protein expression. It has been reported that prolonged restraint stress load can result in the increase of caspase-3 and apoptosis in rats 44 .…”

Section: Discussionmentioning

confidence: 99%

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

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[Purpose]To determine whether voluntary exercise (wheel running) has the potential of relieving stress. [Methods]In this study, restraint stress with or without voluntary wheel running was performed for mice housed in individual cages. A total of 21 ICR male mice were assigned into control (CON), restraint stress with voluntary exercise (RSVE), or restraint stress (RS) without voluntary exercise groups (n = 7 each). [Results]No significant difference in body weight increase was found among the three groups, although CON and RS groups had a tendency of having smaller body weight increase compared to the RSVE group. No significant difference in the expression level of liver heat shock protein 70, Bcl-2, or p53 was found among the three groups. However, caspase-3 protein level in RS group was significantly higher than that in the other two groups. Blood cortisol concentration in RS was higher (p < 0.05) than that in RSVE or CON group. It was the lowest (p < 0.05) in the RSVE group. [Conclusion]Our findings suggest that apoptosis caused by chronic restraint stress might be suppressed by voluntary exercise in mice.

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“…This might have affected caspase-3 protein expression. It has been reported that prolonged restraint stress load can result in the increase of caspase-3 and apoptosis in rats 44 .…”

Section: Discussionmentioning

confidence: 99%

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

View full text Add to dashboard Cite

show abstract

“…Additionally, one of the primary mechanisms responsible for the behavioural impairments induced by exposure to chronic stress may be related to excessive apoptosis 45, 46 . Specifically, different types of chronic stress have been shown to induce apoptosis in the hippocampus 47 . However, unlike the reports described above, significant differences in the regulation of apoptosis-related genes and proteins, including Bax and Caspase-3, were not observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus

Jiang

et al. 2017

Sci Rep

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Although the anxiolytic-like effects of Xiaoyaosan, a Chinese herbal formula, have been described in many previous studies, its underlying mechanism remains undefined. The cytokine tumour necrosis factor-α (TNF-α) and its closely associated janus kinase 2 (JAK2)-signal transducer and activator of transcription (STAT3) signalling pathway regulate the neuro-inflammatory response in the brain, thus participating in the development of anxiety. Our purpose was to investigate whether the anxiolytic-like effects of Xiaoyaosan are related to the TNF-α/JAK2-STAT3 pathway in the hippocampus. We examined the effects of Xiaoyaosan on behaviours exhibited in the elevated plus maze test, open field test and novelty-suppressed feeding test as well as hippocampal neuron damage and changes in the TNF-α/JAK2-STAT3 pathway in a rat model of chronic immobilization stress (CIS)-induced anxiety. Xiaoyaosan exerts anxiolytic-like effects on CIS-induced anxiety, with a significant alleviation of anxiety-like behaviours, an attenuation of hippocampal neuron damage, and a reversal of the activation of the TNF-α/JAK2-STAT3 pathway in the hippocampus that are similar to the effects of the JAK2 antagonist AG490. However, Xiaoyaosan and AG490 failed to effectively regulate apoptosis-related factors, including Bax and Caspase-3. These results suggest that Xiaoyaosan attenuates stress-induced anxiety behaviours by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus.

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General Experimental Techniques

2020

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Chronic restraint increases apoptosis in the hippocampus of rats with high responsiveness to fear stimuli

Cited by 9 publications

References 30 publications

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus

General Experimental Techniques

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