Chronic sinusitis in severe asthma is related to sputum eosinophilia

Brinke, Anneke ten; Grootendorst, Diana C.; Schmidt, Judith Th.; Bruı̈ne, Francisca T. de; Buchem, Mark A. van; Sterk, Peter J.; Rabe, Klaus F.; Bel, Elisabeth H.

doi:10.1067/mai.2002.122458

Cited by 286 publications

(221 citation statements)

References 30 publications

Supporting

Mentioning

196

Contrasting

Unclassified

Order By: Relevance

“…Evidence for rhinosinusitis has been reported to be as high at 75-80% [141,144]. Nasal polyps are seen in a small subset of adults.…”

Section: Remarksmentioning

confidence: 97%

“…Gastro-oesophageal reflux (GOR) is present in 60-80% [15,23,120,141,144], but clinical trials with antireflux therapy generally show little to no effect on asthma control [145][146][147]. The role of ''silent'' GOR disease (GORD) as a cause of poor asthma control in general may be over-emphasised, but the child with gastrointestinal symptoms and problematic asthma should be evaluated and treated for GORD [147].…”

Section: Remarksmentioning

confidence: 99%

See 1 more Smart Citation

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

et al. 2013

Self Cite

View full text Add to dashboard Cite

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A Task Force, supported by the European Respiratory Society and American Thoracic Society, reviewed the definition and provided recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults.A literature review was performed, followed by discussion by an expert committee according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for development of specific clinical recommendations.When the diagnosis of asthma is confirmed and comorbidities addressed, severe asthma is defined as asthma that requires treatment with high dose inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming “uncontrolled” or that remains “uncontrolled” despite this therapy. Severe asthma is a heterogeneous condition consisting of phenotypes such as eosinophilic asthma. Specific recommendations on the use of sputum eosinophil count and exhaled nitric oxide to guide therapy, as well as treatment with anti-IgE antibody, methotrexate, macrolide antibiotics, antifungal agents and bronchial thermoplasty are provided.Coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy.

show abstract

“…Evidence for rhinosinusitis has been reported to be as high at 75-80% [141,144]. Nasal polyps are seen in a small subset of adults.…”

Section: Remarksmentioning

confidence: 97%

Section: Remarksmentioning

confidence: 99%

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…These results confirm previous published evidence that clinical symptom scores are not predictive of either the presence or extent of sinus disease in most cases. [6][7][8]16 This is not surprising insofar as many of the symptoms that are used to evaluate sinus disease such as headache, posterior pharyngeal drainage, purulent nasal drainage, nasal congestion, and toothache are not specific for this disease. These symptoms are more reflective of the presence of nasal disease including all of the causes of perennial rhinitis.…”

Section: Discussionmentioning

confidence: 99%

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Peters¹,

Hatley²,

Crater³

et al. 2003

Annals of Allergy, Asthma & Immunology

View full text Add to dashboard Cite

show abstract

“…Clinical studies have demonstrated that 50–90% of subjects with severe asthma have signs of chronic rhinosinusitis [62,63]. Patients with CRS may have co-existing nasal polyps (CRSwNP), which is commonly a feature of severe late-onset, eosinophilic asthma, and may furthermore be associated with Aspirin/NSAID sensitivity [56].…”

Section: Systematic Assessment Of Severe Asthmamentioning

confidence: 99%

“…Patients with CRS may have co-existing nasal polyps (CRSwNP), which is commonly a feature of severe late-onset, eosinophilic asthma, and may furthermore be associated with Aspirin/NSAID sensitivity [56]. Patients with difficult asthma and CRS report more lung symptoms, in particular more cough and sputum, and have more exacerbations [62]. …”

Section: Systematic Assessment Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

View full text Add to dashboard Cite

Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma (‘difficult asthma’) should undergo systematic assessment, in order to differentiate between true severe asthma, and ‘difficult-to-treat’ patients, in whom poor control is related to factors such as poor adherence or co-morbidities. The Nordic Consensus Statement on severe asthma was developed by the Nordic Severe Asthma Network, consisting of members from Norway, Sweden, Finland, Denmark, Iceland and Estonia, including representatives from the respective national respiratory scientific societies with the aim to provide an overview and recommendations regarding the diagnosis, systematic assessment and management of severe asthma. Furthermore, the Consensus Statement proposes recommendations for the organization of severe asthma management in primary, secondary, and tertiary care.

show abstract

Chronic sinusitis in severe asthma is related to sputum eosinophilia

Cited by 286 publications

References 30 publications

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Contact Info

Product

Resources

About