Chronic social stress does not affect behavioural habituation in male CD1 mice

Boleij, Hetty; Willems, Jeroen; Leijten, Marieke; Klooster, José van’t; Lesscher, Heidi M. B.; Kirchhoff, Susanne; Lavrijsen, Marla; Arndt, Saskia S.; Ohl, Frauke

doi:10.1016/j.bbr.2014.07.015

Cited by 8 publications

(10 citation statements)

References 52 publications

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“…SIS 49D applied to adolescent male CD1 mice also decreases Nr3c1 and Nr3c2 expression in the hippocampus, a brain region implicated in (spatial) memory ( Scharf et al, 2013 ; Schmidt et al, 2007 , 2010a ; Sterlemann et al, 2008 ). Similar effects were observed in another study with adolescent male CD1 mice, but these effects appear dependent on whether mice had been tested in a behavioral assay before the assessment of gene expression ( Boleij et al, 2014 ). Alterations in Nr3c1 or Nr3c2 expression were only present when measured directly after SIS 49D , but when measured one month or one year after SIS, expression levels normalized again or even appeared increased ( Scharf et al, 2013 ; Schmidt et al, 2010b ; Sterlemann et al, 2008 ).…”

Section: Resultssupporting

confidence: 68%

“…Several articles report no effect of SIS 49D on body weight growth in adolescent male CD1 mice ( Scharf et al, 2013 ; Schmidt et al, 2007 , 2010b ). However, two articles report decreased body weight growth either after SIS 49D applied to adolescent male CD1 mice ( Boleij et al, 2014 ) or after 19-day SIS applied to young-adult male SJL mice ( Chatterjee et al, 2009 ). The lag in body weight growth was normalized within two weeks following SIS 49D ( Boleij et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

“…However, two articles report decreased body weight growth either after SIS 49D applied to adolescent male CD1 mice ( Boleij et al, 2014 ) or after 19-day SIS applied to young-adult male SJL mice ( Chatterjee et al, 2009 ). The lag in body weight growth was normalized within two weeks following SIS 49D ( Boleij et al, 2014 ). Twenty-eight-day SIS applied to adult female CD1 mice decreases body weight gain and reduces caloric intake compared to non-stressed controls ( Dadomo et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, SIS 49D applied to adolescent male CD1 mice generally increases adrenal weight and decreases thymus weight compared to non-stressed controls ( Scharf et al, 2013 ; Schmidt et al, 2007 , 2010a , 2010b ; Sterlemann et al, 2008 ). SIS 49D applied to adolescent male CD1 mice also induces an impoverished fur condition, indicative of decreased general health in stressed mice compared to non-stressed controls ( Boleij et al, 2014 ; Schmidt et al, 2007 ).…”

Section: Resultsmentioning

confidence: 99%

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The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations

Koert

Ploeger

Bockting

et al. 2021

Neurobiology of Stress

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Background Social stress is an important environmental risk factor for the development of psychiatric disorders, including depression and anxiety disorders. Social stress paradigms are commonly used in rats and mice to gain insight into the pathogenesis of these disorders. The social instability stress (SIS) paradigm entails frequent (up to several times a week) introduction of one or multiple unfamiliar same-sex home-cage partners. The subsequent recurring formation of a new social hierarchy results in chronic and unpredictable physical and social stress. Purpose We compare and discuss the stress-related behavioral and physiological impact of SIS protocols in rat and mouse, and address limitations due to protocol variability. We further provide practical recommendations to optimize reproducibility of SIS protocols. Methods We conducted a systematic review in accordance with the PRISMA statement in the following three databases: PubMed, Web of Science and Scopus. Our search strategy was not restricted to year of publication but was limited to articles in English that were published in peer-reviewed journals. Search terms included "social* instab*” AND ("animal” OR "rodent” OR "rat*” OR "mice” OR "mouse”). Results Thirty-three studies met our inclusion criteria. Fifteen articles used a SIS protocol in which the composition of two cage mates is altered daily for sixteen days (SIS 16D ). Eleven articles used a SIS protocol in which the composition of four cage mates is altered twice per week for 49 days (SIS 49D ). The remaining seven studies used SIS protocols that differed from these two protocols in experiment duration or cage mate quantity. Behavioral impact of SIS was primarily assessed by quantifying depressive-like, anxiety-like, social-, and cognitive behavior. Physiological impact of SIS was primarily assessed using metabolic parameters, hypothalamus-pituitary-adrenal axis activity, and the assessment of neurobiological parameters such as neuroplasticity and neurogenesis. Conclusion Both shorter and longer SIS protocols induce a wide range of stress-related behavioral and physiological impairments that are relevant for the pathophysiology of depression and anxiety disorders. To date, SIS 16D has only been reported in rats, whereas SIS 49D has only been reported in mice. Given this species-specific application as well as variability in reported SIS protocols, additional studies should determine whether SIS effects are protocol duration- or species-specific. We address several issues, including a lack of consistency in the used SIS protocols, and suggest practical, concrete improvements in design and reporting of SIS protocols to increase standardization and reproducibility of this etiologically relevant preclinical model of social stress.

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Section: Resultssupporting

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations

Koert

Ploeger

Bockting

et al. 2021

Neurobiology of Stress

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show abstract

“…The chronically stressed groups did not display any significant changes in corticosterone secretion. This was expected, given the previously observed habituation-like effects seen in chronically stressed animals (Bowens et al, 2012, Boleij et al, 2014. As mentioned previously, a dampening of the stress response observed during repeated stressor exposures might serve as an adaptive response, enabling the animals to cope with the stressor, but is also associated with depressive-like phenotypes (Thompson and Spencer, 1966, Eisenstein and Eisenstein, 2006, Bowens et al, 2012.…”

Section: Corticosteronementioning

confidence: 55%

An Investigation of the Effect of Vicarious Social Defeat Stress on Stress Hormones and Food Consumption in Male Mice

Chin¹

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In addition to causing depressive-like behaviours in rodents, stressors can also alter feeding behaviour and body weight. The current study aimed to investigate the vicarious social defeat stress model as a means of studying the effects of stressors on feeding, in a manner that allows for comparison between directly affected victim animals and witnesses to social defeat. Increased corticosterone secretion occurred in both acutely treated victim and witness animals 10 minutes following stressor exposure, an effect that persisted in the victim animals for 1.5 hours. No significant effects were found in chronically treated groups, which may be the result of a habituation-like effect to repeated stressor exposures. No significant changes were found in food consumption, weight gain, or plasma ghrelin. Overall, these findings shed light on the impact of social stressors and the consequences of being involved in, compared to witnessing, social defeat.

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Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers

et al. 2016

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Chronic social stress does not affect behavioural habituation in male CD1 mice

Cited by 8 publications

References 52 publications

The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations

The social instability stress paradigm in rat and mouse: A systematic review of protocols, limitations, and recommendations

An Investigation of the Effect of Vicarious Social Defeat Stress on Stress Hormones and Food Consumption in Male Mice

Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers

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