Chronic spontaneous urticaria associated with vitiligo and thyroiditis (autoimmune polyglandular syndrome <scp>IIIC</scp>): case series

Kolkhir, Pavel; Pogorelov, Dmitry; Kochergin, Nikolay G.

doi:10.1111/ijd.13538

Cited by 10 publications

(4 citation statements)

References 11 publications

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“… 47 48 In other studies, cyclosporine was more effective in CSU patients with ASST and/or BHRA positivity and raised thyroid autoantibodies. 49 50 …”

Section: Discussionmentioning

confidence: 99%

Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria

Kolkhir

Altrichter

Asero

et al. 2021

Allergy Asthma Immunol Res

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Purpose Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. Methods We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay. Results Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune diseases were Hashimoto's thyroiditis (HT) (≥ 21%) and vitiligo (2%). Two percent of CSU patients had ≥ 2 autoimmune diseases, most frequently HT plus vitiligo. Comorbid autoimmune diseases, in patients with CSU, were associated with female sex, a family history of autoimmune diseases, and higher rates of hypothyroidism and hyperthyroidism ( P < 0.001). Presence of autoimmune diseases was linked to aiCSU ( P = 0.02). The risks of having autoimmune diseases were 1.7, 2.9 and 3.3 times higher for CSU patients with a positive ASST, BHRA and BAT, respectively. In CSU patients, markers for autoimmune diseases, antinuclear antibodies and/or IgG anti-thyroid antibodies were associated with non-response to omalizumab treatment ( P = 0.013). Conclusions In CSU, autoimmune diseases are common and linked to type IIb autoimmune CSU. Our results suggest that physicians assess and monitor all adult patients with CSU for signs and symptoms of common autoimmune diseases, especially HT and vitiligo.

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“… 47 48 In other studies, cyclosporine was more effective in CSU patients with ASST and/or BHRA positivity and raised thyroid autoantibodies. 49 50 …”

Section: Discussionmentioning

confidence: 99%

Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria

Kolkhir

Altrichter

Asero

et al. 2021

Allergy Asthma Immunol Res

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“…Case reports and case series have linked CU with vitiligo and alopecia areata, which are sometimes collectively referred to as “autoimmune polyglandular syndrome” type 3 (which encompasses autoimmune thyroiditis, vitiligo, and other skin‐related autoimmune disease) . In a recent case series of six CU patients, CU was linked to vitiligo and thyroiditis .…”

Section: Discussionmentioning

confidence: 99%

Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population‐based study

2018

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“…Migration to different geographic regions with different ambient temperatures might decrease the risk of development of CIndU such as ColdU. Finally, tertiary prevention is possible with treatment of symptoms using guideline-recommended options, for example antihistamines and omalizumab 4 , and might be possible with induction of long-lasting remission with disease-modifying treatments, for example allergen-specific immune therapy in patients with allergic urticaria 84 , cyclosporine in patients with autoimmune CSU 141,142 and novel mast cell-reducing therapies 143 .…”

Section: Preventionmentioning

confidence: 99%

Urticaria

Kolkhir

Giménez‐Arnau

Kulthanan

et al. 2022

Nat Rev Dis Primers

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Chronic spontaneous urticaria associated with vitiligo and thyroiditis (autoimmune polyglandular syndrome IIIC): case series

Cited by 10 publications

References 11 publications

Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria

Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria

Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population‐based study

Urticaria

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