Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning

Dagnino‐Subiabre, Alexies; Muñoz-Llancao, Pablo; Terreros, Gonzalo; Wyneken, Úrsula; Dı́az-Véliz, Gabriela; Porter, Benjamin A.; Kilgard, Michael P.; Atzori, Marco; Aboitiz, Francisco

doi:10.1016/j.bbr.2009.04.024

Cited by 19 publications

(14 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Averages are calculated for each IRT. None of the drugs used, changed the latency of premature responses at any IRT (unpaired Student's t-test) activation of a startle response, which is evoked by 10 dB louder stimuli (Floody and Kilgard 2007;Dagnino-Subiabre et al 2009), while 80-85-dB sounds as used in our experiment evokes a non-startle response (Valsamis and Schmid 2011). The dependence on NT dose is described by a Yerkes-Dodson inverted Ushaped relationship, consistent with a performance correlating with the phasic release of NE.…”

Section: Inverse U-shaped Dependence Of Performance On Ntmentioning

confidence: 70%

α2- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Inverse U-shaped Dependence Of Performance On Ntmentioning

confidence: 70%

α2- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…Lesion studies in the main nuclei of the auditory system that regulates learning, the inferior colliculus (IC, auditory mesencephalon) and the medial geniculate nucleus (MG, auditory thalamus), have demonstrated that the two brain structures are key factors for acquiring aversive memories to auditory cues during fear conditioning in rats [64]. As well, restraint stress induces dendritic atrophy in the IC, MG, and primary auditory cortex, and affects auditory processing [27,65,66]. A recent study using micro Positron Emission Tomography supports these findings, in that chronic mild stress induced a significant decrease in glucose metabolism in the IC, but not in the superior colliculus (visual mesencephalon) [67].…”

Section: Discussionmentioning

confidence: 99%

“…The positive effect of ω-3 supplementation on the learning could be related to a direct effect of ω-3 on the auditory brain nuclei that modulates fear learning, such as the MG and IC, which are affected in the stressed rats [65,67]. Chronic stress may have decreased proplastic protein levels in the brain nuclei that produce dendritic atrophy.…”

Section: Discussionmentioning

confidence: 99%

Long-term ω-3 fatty acid supplementation induces anti-stress effects and improves learning in rats

2013

Self Cite

View full text Add to dashboard Cite

Chronic stress leads to secretion of the adrenal steroid hormone corticosterone, inducing hippocampal atrophy and dendritic hypertrophy in the rat amygdala. Both alterations have been correlated with memory impairment and increased anxiety. Supplementation with ω-3 fatty acids improves memory and learning in rats. The aim of this study was to evaluate the effects of ω-3 supplementation on learning and major biological and behavioral stress markers. Male Sprague–Dawley rats were randomly assigned to three experimental groups: 1) Control, 2) Vehicle, animals supplemented with water, and 3) ω-3, rats supplemented with ω-3 (100 mg of DHA+25 mg of EPA). Each experimental group was divided into two subgroups: one of which was not subjected to stress while the other was subjected to a restraint stress paradigm. Afterwards, learning was analyzed by avoidance conditioning. As well, plasma corticosterone levels and anxiety were evaluated as stress markers, respectively by ELISA and the plus-maze test. Restraint stress impaired learning and increased both corticosterone levels and the number of entries into the open-arm (elevated plus-maze). These alterations were prevented by ω-3 supplementation. Thus, our results demonstrate that ω-3 supplementation had two beneficial effects on the stressed rats, a strong anti-stress effect and improved learning.

show abstract

“…[21] Furthermore, dendritic atrophy was observed in inflammation,[22] and it has been proved earlier that psychosocial stress can induce dendritic atrophy,[23] and it was revealed that chronic stress can lead to dendritic atrophy in MGB. [24] Accordingly, this increased volume of MGB may be attributed as the consequence of inflammatory responses to audiogenic stress. Nonetheless, further validation studies are required to evaluate this finding.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Acoustic White Noise on the Rat Central Auditory System During the Fetal and Critical Neonatal Periods: A Stereological Study

et al. 2017

View full text Add to dashboard Cite

Aim:To evaluate the effects of long-term, moderate level noise exposure during crucial periods of rat infants on stereological parameters of medial geniculate body (MGB) and auditory cortex.Materials and Methods:Twenty-four male offspring of 12 pregnant rats were divided into four groups: fetal-to-critical period group, which were exposed to noise from the last 10 days of fetal life till postnatal day (PND) 29; fetal period group that exposed to noise during the last 10 days of fetal life; critical period group, exposed to noise from PND 15 till PND 29, and control group. White noise at 90 dB for 2 h per day was used.Statistical Analysis Used:Variance for variables was performed using Proc GLM followed by mean comparison by Duncan’s multiple range test.Results:Numerical density of neurons in MGB of fetal-to-critical period group was lower than control group. Similar results were seen in numerical density of neurons in layers IV and VI of auditory cortex. Furthermore, no significant difference was observed in the volume of auditory cortex among groups, and only MGB volume in fetal-to-critical period group was higher than other groups. Estimated total number of neurons in MGB was not significantly different among groups.Conclusion:It seems necessary to prevent long-term moderate level noise exposure during fetal-to-critical neonatal period.

show abstract

Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning

Cited by 19 publications

References 42 publications

α2- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity

α2- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity

Long-term ω-3 fatty acid supplementation induces anti-stress effects and improves learning in rats

The Effects of Acoustic White Noise on the Rat Central Auditory System During the Fetal and Critical Neonatal Periods: A Stereological Study

Contact Info

Product

Resources

About