Chronic Subdural Hematoma Caused by Acute Myeloblastic Leukemia: A Case Report

Xia, Guang‑Wen; Zhang, Weitao; Xiao, Jing; Shi, Lin; Zhang, Yiming; Xue, Hang

doi:10.3389/fneur.2022.911195

Cited by 3 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spontaneous SDHs are rare and occur secondary to coagulopathy disorders, often in the setting of a hematological malignancy. Patients with acute leukemia can present with SDH either at the time of initial diagnosis or later during the course of the illness [8]. A spontaneous SDH can be the presenting manifestation of acute leukemia and CML [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Middle Meningeal Artery Embolization in Acute Leukemia Patients Presenting With Subdural Hematoma

Yohannan,

Martinez Gutierrez,

Chen

et al. 2024

J Hematol

View full text Add to dashboard Cite

Intracerebral hemorrhage is a potentially fatal complication in patients with acute leukemia and contributing factors include thrombocytopenia and coagulopathy. Patients with acute leukemia may develop subdural hematoma (SDH) spontaneously or secondary to trauma. In patients with acute leukemia and SDH, the surgical evacuation of the hematoma causes significant morbidity and mortality. New approaches and strategies to reduce the need for surgical evacuation are needed to improve outcomes in patients with acute leukemia and intracerebral hemorrhage. We report two cases of acute SDH in patients with acute leukemia successfully treated with middle meningeal artery embolization, a minimally invasive interventional radiology technique, obviating the need for a surgical intervention. The first patient with acute promyelocytic leukemia (APL) presented with coagulopathy and developed an acute SDH after a fall. The second patient with acute myeloid leukemia presented with gum bleeding and also sustained an acute SDH after a fall. Both patients underwent middle meningeal artery embolization for treating their SDHs while actively receiving induction chemotherapy for acute leukemia. Both patients had resolution of their acute SDH and are in remission from their acute leukemia. Middle meningeal artery embolization is a very effective, and within the context of this setting, a novel, minimally invasive technique for management of SDH in acute leukemia patients, which can prevent the need for surgical interventions with its associated comorbidities and high risk of fatal outcomes in patients with acute leukemia and acute SDH.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Patients with acute leukemia can present with SDH either at the time of initial diagnosis or later during the course of the illness [8]. A spontaneous SDH can be the presenting manifestation of acute leukemia and CML [8][9][10][11]. The reported incidence of SDH in patients with acute leukemia can range from 0.47% to 6% [12,13].…”

Section: Discussionmentioning

confidence: 99%

Middle Meningeal Artery Embolization in Acute Leukemia Patients Presenting With Subdural Hematoma

Yohannan,

Martinez Gutierrez,

Chen

et al. 2024

J Hematol

View full text Add to dashboard Cite

show abstract

“…Only a few reports in the literature have described the clinical course of patients with AML and refractory CSDH. 9 , 13) In one case report, the hematoma was surgically evacuated, and then oral atorvastatin was administered, resulting in no recurrence of the CSDH. 13) One large study included two cases of refractory CSDH and associated AML that were treated using MMA embolization.…”

Section: Discussionmentioning

confidence: 99%

“… 9 , 13) In one case report, the hematoma was surgically evacuated, and then oral atorvastatin was administered, resulting in no recurrence of the CSDH. 13) One large study included two cases of refractory CSDH and associated AML that were treated using MMA embolization. 9) However, details of the clinical course after MMA embolization and surgical outcomes of the patients were not described in this case series.…”

Section: Discussionmentioning

confidence: 99%

Middle Meningeal Artery Embolization for Refractory Chronic Subdural Hematoma Associated with Acute Myeloid Leukemia: A Case Report

Kojima,

Hosoi,

Hayashi

et al. 2024

JNET

View full text Add to dashboard Cite

Objective We describe a patient with leukemia–related chronic subdural hematoma (CSDH) who was successfully treated using the combination of surgical evacuation and middle meningeal artery (MMA) embolization. Case Presentation A 73-year-old man without apparent head trauma history was admitted to our hospital because of acute myeloid leukemia (AML). Head CT on admission revealed mild CSDH on both sides. Medical treatment options, including chemotherapy, were started. Since a decrease in platelet count and disseminated intravascular coagulation were observed on day 4, recombinant thrombomodulin was administered. As the patient exhibited signs of altered consciousness due to the enlargement of the right CSDH on day 10, we performed surgical drainage. Despite subsequent platelet transfusion and administration of goreisan, the right CSDH recurred within a short period. On day 17, we performed the second surgery and MMA embolization in one stage. The postoperative clinical course was favorable without recurrence of the hematoma. The patient eventually died on day 123 from a deterioration of his general condition. Conclusion Although MMA embolization has recently been recognized as an effective treatment option for recurrent CSDH, there are no published reports addressing the efficacy of MMA embolization for refractory CSDH associated with hematological malignancies. Findings from the management of this case suggest that MMA embolization can be the effective treatment option for CSDH in patients with severe hemorrhagic diathesis due to AML.

show abstract

“…Sometimes, chronic subdural hematomas can occur due to hematological malignancies [ 5 ]. A case of chronic subdural hematoma caused by acute myeloblastic leukemia in a 67-year-old male has been reported [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Non-traumatic Chronic Subdural Hematoma With Myelodysplastic Syndrome: A Case Report

Irfan¹,

Kurakula²,

Singh³

et al. 2023

Cureus

View full text Add to dashboard Cite

Spontaneous chronic subdural hematoma is a rare condition that appears in association with myelodysplastic syndrome. A 25-year-old male with a known case of myelodysplastic syndrome presented to the emergency department with a headache and loss of consciousness. Considering ongoing chemotherapy, burr hole trephination of the chronic subdural hematoma was performed, and he was discharged following a successful procedure. To the best of our knowledge, this is the first report of myelodysplastic syndrome with spontaneous chronic subdural hematoma.

show abstract

Chronic Subdural Hematoma Caused by Acute Myeloblastic Leukemia: A Case Report

Cited by 3 publications

References 15 publications

Middle Meningeal Artery Embolization in Acute Leukemia Patients Presenting With Subdural Hematoma

Middle Meningeal Artery Embolization in Acute Leukemia Patients Presenting With Subdural Hematoma

Middle Meningeal Artery Embolization for Refractory Chronic Subdural Hematoma Associated with Acute Myeloid Leukemia: A Case Report

Non-traumatic Chronic Subdural Hematoma With Myelodysplastic Syndrome: A Case Report

Contact Info

Product

Resources

About