Chronic Subdural Hematoma: So Common and So Neglected

Welling, Leonardo C.; Welling, Mariana S.; Teixeira, Manoel Jacobsen; Figueiredo, Eberval Gadelha

doi:10.1016/j.wneu.2018.01.131

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…Захворюваність на ХСДГ коливається в межах 8,2-17,6 випадків на 100 тис. населення на рік, за іншими даними -79,4 на 100 000 осіб на рік та зустрічається переважно у людей похилого віку [4,5]. Останнім часом спостерігається ріст захворюваності, ймовірно внаслідок збільшення кількості населення, що старіє, а також наявності супутніх хвороб, які потребують гемодіалізу, антикоагулянтної та/або антитромбоцитарної терапії [6].…”

Section: полтавський державний медичний університет українаunclassified

The Case of Non-Traumatic Subdural Hematoma

Mustafina¹,

Филенко²,

Cherniak³

et al. 2022

Ukr. ž. med. bìol. sportu

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The risk for the development of subacute or chronic subdural hematoma is associated with the widespread use of anticoagulant therapy for both prophylactic and therapeutic purposes. Therefore, the purpose of the study was to carry out clinical and morphological analysis of the case of chronic subdural hematoma associated with the use of antithrombotic therapy to substantiate the pathogenetic links of their relationship. Materials and methods. The case report. The body of a woman with signs of bodily injuries was found in the apartment at the place of residence. The autopsy along the entire length of the vertebral canal revealed a draining thin-layer subdural hemorrhage in the form of layers of liquid dark red blood, which effortlessly filled all the free spaces between the dura mater and arachnoid mater. The bones of the vault, the base and the frontal skeleton of the skull were intact. The dura mater was moderately tense, grayish in color, with the bones of the skull tightly fused in all parts of the skull. On the convex and basal surfaces of both hemispheres of the brain with spread between the hemispheres of the brain, around the cerebellum and trunk with penetration into the large occipital foramen, subdural hemorrhage in the form of layers of thick dark red blood was found. Forensic histological examination of pieces of internal organs revealed hemorrhage under the dura mater of the brain and spinal cord with reactive inflammatory changes, deposition of hemosiderin granules. Forensic toxicological analysis of blood, urine, stomach and small intestine contents, liver and gallbladder and kidneys revealed diclofenac and an unknown substance that might be an anticoagulant; however, it could not be identified by the approved methods due to the limited number of comparison samples. Examination of the corpse in the apartment revealed blisters and ampoules of various drugs in the largest amount of diclofenac, warfarin. Results and discussion. The analysis of the data obtained on the scene, as well as from the medical history, records in the available medical documentation, morphological characteristics of detected hemorrhages, results of forensic toxicological and forensic histological studies have established that hemorrhages might have occurred due to uncontrolled use of diclofenac and warfarin. Conclusion. Subdural hematomas are currently the topical medical and social issue due to the significant growing rate of its incidence. Based on this case, it can be stated that the development of chronic subdural hematoma is caused by the combination of mild trauma and inflammatory response in the damaged dura mater with potentiation of hematoma formation through the use of antithrombotic drugs

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Section: полтавський державний медичний університет українаunclassified

The Case of Non-Traumatic Subdural Hematoma

Mustafina¹,

Филенко²,

Cherniak³

et al. 2022

Ukr. ž. med. bìol. sportu

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“…Chronic subdural hematoma (CSDH) is a common disease in neurosurgical practice and is characterized by the collection of blood products in the subdural space, along with the formation of membranes with abnormal neovessels. 1 , 2 ) Meanwhile, dural arteriovenous fistula (DAVF) is a vascular entity that consists of direct pathologic connections between meningeal arteries and dural venous sinuses or leptomeningeal veins. 3 - 5 ) Several studies have presented cases of coexisting CSDH and DAVF.…”

Section: Introductionmentioning

confidence: 99%

Possible Association between Recurrent Chronic Subdural Hematoma and Dural Arteriovenous Fistula: A Case Report with Three-dimensional Fusion Images

Yajima

Koizumi

Kanda

et al. 2023

NMC Case Report Journal

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Several studies have reported the coexistence of chronic subdural hematoma (CSDH) and dural arteriovenous fistula (DAVF); however, the association between these two entities remains unknown. A case of coexisting CSDH and DAVF that was successfully treated with burr hole surgery and middle meningeal artery (MMA) embolization is reported herein. We visualized the positional relationship between CSDH and DAVF by fusion three-dimensional computer graphics images reconstructed from multimodal imaging studies, which revealed that the shunt point of the DAVF was far from the burr hole and was in contact with the CSDH membrane at the center of the CSDH. Additionally, the chronological development of CSDH in the presence of DAVF and the complete disappearance of both DAVF and CSDH after MMA embolization were also demonstrated. This study suggests a possible association between recurrent CSDH and DAVF.

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“…With the population aging, the incidence rate has been increasing year by year and has become a national health burden [4]. The onset of CSDH is insidious with slow progression, which develops over course of 3 or more weeks [5]. As the hematoma expands, however, it can compress the peripheral nerve conduction tracts and brain tissue, and the mass effect of the hematoma also increases intracranial pressure, which affects blood flow and further causes brain tissue damage [3,6].…”

Section: Introductionmentioning

confidence: 99%

LC‐MS‐based urine metabolomics analysis of chronic subdural hematoma for biomarker discovery

Sun,

Ou,

Liu

et al. 2023

Proteomics Clinical Apps

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BackgroundChronic subdural hematoma (CSDH) is one of the most common neurosurgical diseases with atypical manifestations. The aim of this study was to utilize urine metabolomics to explore potential biomarkers for the diagnosis and prognosis of CSDH.MethodsSeventy‐seven healthy controls and ninety‐two patients with CSDH were enrolled in our study. In total, 261 urine samples divided into the discovery group and validation group were analyzed by LC‐MS. The statistical analysis and functional annotation were applied to discover potential biomarker panels and altered metabolic pathways.ResultsA total of 53 differential metabolites were identified in this study. And the urinary metabolic profiles showed apparent separation between patients and controls. Further functional annotation showed that the differential metabolites were associated with lipid metabolism, fatty acid metabolism, amino acid metabolism, biotin metabolism, steroid hormone biosynthesis, and pentose and glucuronate interconversions. Moreover, one panel of Capryloylglycine, cis‐5‐Octenoic acid, Ethisterone, and 5,6‐DiHETE showed good predictive performance in the diagnosis of CSDH, with an AUC of 0.89 in discovery group and an AUC of 0.822 in validation group. Another five metabolites (Trilobinol, 3′‐Hydroxyropivacaine, Ethisterone, Arginyl‐Proline, 5‐alpha‐Dihydrotestosterone glucuronide) showed the levels of them returned to a healthy state after surgery, showing good possibility to monitor the recovery of CSDH patients.Conclusion and Clinical RelevanceThe findings of the study revealed urine metabolomic differences between CSDH and controls. The potentially diagnostic and prognostic biomarker panels of urine metabolites were established, and functional analysis demonstrated deeper metabolic disorders of CSDH, which might conduce to improve early diagnose of CSDH clinically.

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Chronic Subdural Hematoma: So Common and So Neglected

Cited by 10 publications

References 6 publications

The Case of Non-Traumatic Subdural Hematoma

The Case of Non-Traumatic Subdural Hematoma

Possible Association between Recurrent Chronic Subdural Hematoma and Dural Arteriovenous Fistula: A Case Report with Three-dimensional Fusion Images

LC‐MS‐based urine metabolomics analysis of chronic subdural hematoma for biomarker discovery

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