2019
DOI: 10.1101/565499
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Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neurons

Abstract: Exposure to unpredictable environmental stress is widely recognized as a major determinant for risk and severity in neuropsychiatric disorders such as major depressive disorder, anxiety, schizophrenia, and PTSD. The ability of ostensibly unrelated disorders to give rise to seemingly similar psychiatric phenotypes highlights a need to identify circuit-level concepts that could unify diverse factors under a common pathophysiology. Although difficult to disentangle a causative effect of stress from other factors … Show more

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Cited by 8 publications
(7 citation statements)
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References 94 publications
(127 reference statements)
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“…(2.5-4.5 MΩ) filled with a K-Gluconate solution (Hearing et al, 2013;Anderson et al, 2019) to assess spontaneous activity (I=0). Upon achieving whole-cell, cells were permitted to stabilize over a 2-5 min period prior to drug application.…”
Section: Methodsmentioning
confidence: 99%
“…(2.5-4.5 MΩ) filled with a K-Gluconate solution (Hearing et al, 2013;Anderson et al, 2019) to assess spontaneous activity (I=0). Upon achieving whole-cell, cells were permitted to stabilize over a 2-5 min period prior to drug application.…”
Section: Methodsmentioning
confidence: 99%
“…Repeated stress paradigms attenuate working memory via a reduction in the activity of Drd1 expressing pyramidal cells in mPFC 111 . In addition, repeated stress exposure alters excitability and synaptic inputs onto Drd1 and Drd2 cells 112 , and causes atrophy of Drd1 expressing neurons 85 . These studies provide key insights into a discrete population of neurons in the mPFC and the projections of these neurons to the BLA that are necessary and sufficient for the rapid antidepressant actions of ketamine.…”
Section: Sustained Effects Of Mpfc Circuit Manipulationsmentioning
confidence: 99%
“…Further, these models are proved to be helpful in understanding the comprehension of human psychopathology [ 3 ]. Research reports show the impact of chronic unpredictable stress on cellular integration and active involvement of certain brain regions such as DG, prefrontal cortex, and hippocampus [ 4 , 5 ]. The medial prefrontal cortex is an essential neural substrate helping in modulating the hypothalamic-pituitary-adrenal axis during the exposure to stressful situations [ 6 ].…”
Section: Introductionmentioning
confidence: 99%