Chronic Urinary Infection in Overactive Bladder Syndrome: A Prospective, Blinded Case Control Study

Khan, Zainab; Healey, Gareth D.; Paravati, Roberta; Berry, Nidhika; Rees, Eugene; Margarit, Lavinia; González, Deyarina; Emery, Simon; Conlan, R. Steven

doi:10.3389/fcimb.2021.752275

Cited by 7 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, multiple studies have pointed out that the occurrence of OAB is related to tract infections [ 50 – 52 ]. Khan Zainab’s research confirmed that patients with OAB symptoms have significant bacterial growth on enhanced urine culture, which is often undetectable through routine culture, suggesting the possibility of subclinical infection [ 53 ]. A higher likelihood of tract infection was observed in sexually active women.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of overactive bladder in Chinese women: A systematic review and meta-analysis

Huang,

Guo,

Tai

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Background Overactive bladder (OAB) is a significant public health issue that adversely affects the quality of life of patients and imposes a significant socioeconomic burden, with varying prevalence rates across study populations in Chinese women. A systematic review and meta-analysis were conducted to estimate the prevalence of OAB in Chinese women. Methods Relevant published articles on the prevalence of OAB in Chinese women were searched through July 21, 2022, using PubMed, EMbase, The Cochrane Library, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), WanFang Data, and VIP databases. After the independent screening of articles, data extraction, and quality assessment of included studies by two investigators, a meta-analysis was performed using Stata 16.0 software, and the prevalence was determined using a random-effects model. To identify potential sources of heterogeneity, subgroup analyses were conducted with subgroup categories including age, Body Mass Index (BMI), region, and survey year. Publication bias was assessed by visually examining the funnel plot and Egger’s test. Results Twenty studies were included in this meta-analysis. The results of the random-effects model indicated that the prevalence of OAB in Chinese women was 14% (95% Confidence Interval: 9%–18%). The prevalence increased significantly in the past decade (from 8% in pre-2006 to 18% in 2016–2021). A prevalence (18%) was observed among women aged 31–40 compared with other age groups. The BMI range of 24–27.9 (18%) was higher than the other groups. Additionally, the prevalence of this BMI range was comparatively higher in North China and Southwest China (21%) than in Central China and East China. In addition, publication bias was observed. Conclusions OAB incidence has increased in Chinese women over the last two decades, affecting more than 20% of women aged 31–40 years and above. With the increasing prevalence of OAB, greater emphasis has been placed on implementing preventative and control measures.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of overactive bladder in Chinese women: A systematic review and meta-analysis

Huang,

Guo,

Tai

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Interestingly, when both standard (10 5 CFU/ml) and low-count criteria (10 2−3 CFU/ml) are used in samples from the same patient cohort, the proportion of those positive for bacteriuria increases (from 17% to 39%), compared to those of a control group (from 2% to 6%) ( Walsh et al, 2011 ) showing that low-count MSU culture may reveal genuine infections in OAB patients that would otherwise be overlooked. Enhanced culture techniques have also revealed higher rates of infection that were previously missed by routine culture, identifying 23% of patients with OAB as positive for UTI, vs. 10% of controls, in a prospective blinded case control study ( Khan et al, 2021 ).…”

Section: The Emerging Role Of Urinary Tract Infection In Overactive B...mentioning

confidence: 99%

Urinary Tract Infection in Overactive Bladder: An Update on Pathophysiological Mechanisms

et al. 2022

View full text Add to dashboard Cite

Overactive bladder (OAB) is a clinical syndrome defined by urinary urgency, increased daytime urinary frequency and/or nocturia, with or without urinary incontinence, that affects approximately 11% of the western population. OAB is accepted as an idiopathic disorder, and is charactersied clinically in the absence of other organic diseases, including urinary tract infection. Despite this, a growing body of research provides evidence that a significant proportion of OAB patients have active bladder infection. This review discusses the key findings of recent laboratory and clinical studies, providing insight into the relationship between urinary tract infection, bladder inflammation, and the pathophysiology of OAB. We summarise an array of clinical studies that find OAB patients are significantly more likely than control patients to have pathogenic bacteria in their urine and increased bladder inflammation. This review reveals the complex nature of OAB, and highlights key laboratory studies that have begun to unravel how urinary tract infection and bladder inflammation can induce urinary urgency and urinary frequency. The evidence presented in this review supports the concept that urinary tract infection may be an underappreciated contributor to the pathophysiology of some OAB patients.

show abstract

“…High-throughput DNA sequencing and enhanced culture-based investigations have found bacterial DNA and live bacteria, respectively, in catheterized (bladder) urine deemed culture-negative by the standard urine culture method [1][2][3][4][5][6][7][8][9][10][11][12][13]. The expanded quantitative urine culture (EQUC) protocol and similar enhanced (metaculturomic) methods have enabled researchers to isolate species detected by 16S rRNA gene sequencing in both individuals with and without urinary tract symptoms [7,8,11,[13][14][15]. While the genetic diversity of some species has been extensively investigated, e.g., Escherichia coli [16,17], many species have few or no genomic sequences.…”

Section: Introductionmentioning

confidence: 99%

Cataloging the phylogenetic diversity of human bladder bacterial isolates

Du,

Khemmani,

Halverson

et al. 2024

Genome Biol

View full text Add to dashboard Cite

Background Although the human bladder is reported to harbor unique microbiota, our understanding of how these microbial communities interact with their human hosts is limited, mostly owing to the lack of isolates to test mechanistic hypotheses. Niche-specific bacterial collections and associated reference genome databases have been instrumental in expanding knowledge of the microbiota of other anatomical sites, such as the gut and oral cavity. Results To facilitate genomic, functional, and experimental analyses of the human bladder microbiota, we present a bladder-specific bacterial isolate reference collection comprising 1134 genomes, primarily from adult females. These genomes were culled from bacterial isolates obtained by a metaculturomic method from bladder urine collected by transurethral catheterization. This bladder-specific bacterial isolate reference collection includes 196 different species, including representatives of major aerobes and facultative anaerobes, as well as some anaerobes. It captures 72.2% of the genera found when re-examining previously published 16S rRNA gene sequencing of 392 adult female bladder urine samples. Comparative genomic analysis finds that the taxonomies and functions of the bladder microbiota share more similarities with the vaginal microbiota than the gut microbiota. Whole-genome phylogenetic and functional analyses of 186 bladder Escherichia coli isolates and 387 gut Escherichia coli isolates support the hypothesis that phylogroup distribution and functions of Escherichia coli strains differ dramatically between these two very different niches. Conclusions This bladder-specific bacterial isolate reference collection is a unique resource that will enable bladder microbiota research and comparison to isolates from other anatomical sites.

show abstract

Chronic Urinary Infection in Overactive Bladder Syndrome: A Prospective, Blinded Case Control Study

Cited by 7 publications

References 29 publications

Prevalence of overactive bladder in Chinese women: A systematic review and meta-analysis

Prevalence of overactive bladder in Chinese women: A systematic review and meta-analysis

Urinary Tract Infection in Overactive Bladder: An Update on Pathophysiological Mechanisms

Cataloging the phylogenetic diversity of human bladder bacterial isolates

Contact Info

Product

Resources

About